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Nurix Therapeutics, Inc. reports developments as a clinical-stage biopharmaceutical company developing targeted protein degradation medicines for oncology and autoimmune and inflammatory diseases. News commonly centers on bexobrutideg (NX-5948), a Bruton’s tyrosine kinase degrader, including clinical data in chronic lymphocytic leukemia, small lymphocytic lymphoma and Waldenström macroglobulinemia, as well as updates tied to the DAYBreak development program.
Company updates also cover Nurix’s DEL-AI discovery platform, preclinical degrader programs against targets such as pan-mutant BRAF, CBL-B and Aurora kinase A, and partnered inflammation and immunology programs involving IRAK4 and STAT6 degraders. Recurring announcements include financial results, corporate presentations, scientific meeting data, pipeline progress, capital actions and board or governance changes.
Nurix Therapeutics (Nasdaq: NRIX) has appointed Anil Kapur to its board of directors, effective October 15, 2024. Mr. Kapur brings over 25 years of executive experience in pharmaceutical and biotech companies across U.S. and international markets. His expertise in commercial operations and launching novel drugs in hematology and oncology is particularly relevant to Nurix's pipeline.
Mr. Kapur's notable achievements include launching blockbuster drugs Imbruvica and Darzalex while at Johnson & Johnson. He has held senior leadership positions at various companies, including Geron , Actinium Pharmaceuticals, and Bristol-Myers Squibb. Nurix is preparing to advance NX-5948 into pivotal clinical testing in 2025 and is planning for future commercialization.
Nurix Therapeutics (NRIX) reported Q3 fiscal 2024 financial results and provided a corporate update. Key highlights include:
1. Initiated Phase 1b dose expansion of NX-5948 in chronic lymphocytic leukemia and other B-cell malignancies
2. Reinitiated enrollment for NX-2127 in a Phase 1a/b oncology trial
3. Presented preclinical data on Degrader-Antibody Conjugates (DACs)
4. Cash and marketable securities of $457.5 million
Financial results: Collaboration revenue was $12.6 million, down from $18.5 million in Q3 2023. R&D expenses increased to $55.5 million from $47.9 million. Net loss was $49.0 million or ($0.67) per share.
The company anticipates clinical data readouts in Q4 2024 and initiation of pivotal studies for NX-5948 in 2025.
Nurix Therapeutics (Nasdaq: NRIX) announced upcoming presentations of preclinical data at ACR Convergence 2024, the annual meeting of the American College of Rheumatology, held November 14-19, 2024, in Washington, D.C. The presentations will focus on two of Nurix's drug candidates:
1. NX-5948: A BTK degrader in Phase 1b development for B-cell malignancies and IND-enabling studies for autoimmune diseases. The poster will showcase its efficacy in suppressing BCR, TLR, and FcR signaling in immune cells and its performance in preclinical models of arthritis and other inflammatory diseases.
2. GS-6791/NX-0479: An IRAK4 degrader developed in collaboration with Gilead Sciences, currently in IND-enabling studies. The presentation will demonstrate its ability to inhibit TLR and IL-1R-driven inflammatory signaling and its effects in a preclinical arthritis model.
Nurix Therapeutics (Nasdaq: NRIX) announced three oral presentations at the 22nd Annual Discovery on Target conference in Boston, MA, from September 30 to October 3, 2024. The presentations highlight Nurix's DELigase platform capabilities in addressing difficult-to-drug target classes like E3 ligases and transcription factors. The company will present on:
1. A small molecule inhibitor of CBL-B for enhanced T-cell function
2. The chemical space of bi-functional degraders targeting the CNS, including their clinical stage BTK degrader NX-5948
3. Screening DNA binding proteins with DNA Encoded Libraries, focusing on transcription factors
The presentation slides will be available on Nurix's website from October 1, 2024.
Nurix Therapeutics (Nasdaq: NRIX), a clinical-stage biopharmaceutical company, has announced its participation in the upcoming ADC & Radiopharmaceuticals Pharma & Biotech Partnering Summit in Boston from September 9-10, 2024. Dr. Gwenn M. Hansen, the company's chief scientific officer, will present an update on Nurix's Degrader-Antibody Conjugate (DAC) platform on Tuesday, September 10, from 9:05 to 9:25 a.m. ET.
The presentation, titled 'Targeted Protein Degraders As Next Generation Antibody Payloads', will showcase Nurix's innovative approach to developing targeted protein modulation drugs for cancer and inflammatory diseases. Interested parties can access the presentation slides from September 9, 2024, through the Investors section of the Nurix website under Events and Presentations.
Nurix Therapeutics (Nasdaq: NRIX), a clinical stage biopharmaceutical company focusing on targeted protein modulation drugs for cancer and inflammatory diseases, has announced its participation in three upcoming investor conferences in September 2024:
1. 2024 Wells Fargo Healthcare Conference in Boston, MA (September 5)
2. H.C. Wainwright 26th Annual Global Investment Conference in New York City (September 9)
3. Baird 2024 Global Healthcare Conference in New York City (September 10)
Key executives, including CEO Arthur T. Sands, CFO Hans van Houte, and CBO Jason Kantor, will participate in fireside chats and presentations. Most events will be webcast live and accessible through the Investors section of Nurix's website, with recordings available for 30 days after each event.
Nurix Therapeutics (Nasdaq: NRIX) reported its Q2 fiscal 2024 results, highlighting significant advancements. The company showcased positive clinical data for NX-5948 at the European Hematology Association Congress, demonstrating a 69.2% objective response rate in heavily pretreated CLL patients.
Financially, Nurix strengthened its cash position to $452.5 million, largely from a $188.7 million public offering. Key leadership appointments include Dr. Paula G. O’Connor as CMO and Dr. Pasit Phiasivongsa as CTO.
Q2 collaboration revenue grew to $12.1 million from $10.7 million YoY, driven by a milestone with Pfizer. However, R&D expenses increased to $48.9 million, contributing to a net loss of $44.5 million, or ($0.71) per share.
Nurix plans to advance NX-5948 into pivotal trials in 2025, alongside other pipeline developments including NX-2127 and NX-1607.
On July 8, 2024, Nurix Therapeutics (Nasdaq: NRIX), a clinical-stage biopharmaceutical firm focused on developing targeted protein modulation drugs for cancer and inflammatory diseases, announced its participation in the UBS Virtual Targeted Protein Degradation (TPD) Day. Dr. Arthur T. Sands, Nurix's President and CEO, will engage in a fireside chat at 2:30 p.m. ET on July 15, 2024. The discussion will be webcast live and accessible through the Investors section of Nurix's website, under Events and Presentations, and the archived version will remain available for 30 days post-event.
Nurix Therapeutics released positive results for NX-5948 during the EHA 2024 congress. The drug, targeting relapsed/refractory CLL, showed a 69.2% objective response rate in heavily pretreated patients, including those with BTK inhibitor resistance. Responses were rapid and deepened with prolonged treatment. Adverse events were manageable, with common side effects being purpura, thrombocytopenia, and neutropenia. Based on these results, Nurix plans pivotal trials in 2025. A webcast discussing these findings will be held on June 16, 2024, at 9:00 a.m. ET.
Nurix Therapeutics (Nasdaq: NRIX) will host a webcast and conference call on June 16, 2024, at 9:00 a.m. ET to discuss data from its ongoing Phase 1 clinical trial of NX-5948. This presentation will occur in an oral session at the European Hematology Association Congress in Madrid, Spain. The Phase 1a/b study of NX-5948 focuses on heavily pretreated patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. Key points include data on patients with BTK inhibitor resistance mutations and CNS involvement. The oral presentation, titled "Latest results from an ongoing first-in-human Phase 1a/b study of NX-5948," will be presented by Dr. Kim Linton on June 16, 2024, from 11:30 a.m. to 12:45 p.m. CEST.