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Nexentis Technologies Subsidiary MitoCareX Bio Selects Transport Protein Candidate for Drug Discovery Campaign

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Nexentis Technologies (NASDAQ: NXTS) announced that its wholly owned subsidiary MitoCareX Bio has selected a prioritized SLC transport protein candidate for a new drug discovery campaign, following a broad structural analysis of the human SLC transport protein family using its proprietary MITOLINE® platform.

According to Nexentis, the candidate arises from a set of non‑mitochondrial SLC transport proteins previously identified as compatible with MITOLINE®-enabled structural modelling. MitoCareX completed an internal prioritization process and chose a target with favorable characteristics, which the company views as a concrete step in translating its computational discovery capabilities into a focused pipeline.

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Positive

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Negative

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Market Context

The stock is dropping -13.8% following this news. Historical event 1071723 recorded a -8.25% 24-hour...
Analysis

The stock is dropping -13.8% following this news. Historical event 1071723 recorded a -8.25% 24-hour reaction. A negative response would contrast with that prior analysis announcement, while low short positioning offered little evidence of a short-interest-driven explanation; clinical validation remained unreported.

Key Figures

Announcement date: July 28, 2026 MitoCareX ownership: 100% Solar projects: 4 projects +1 more
4 metrics
Announcement date July 28, 2026 Article dateline
MitoCareX ownership 100% Nexentis ownership of MitoCareX Bio
Solar projects 4 projects Projects across European Union countries
Countries represented 3 European Union countries Solar projects introduced by Solterra Renewable Energy

Historical Context

5 past events · Latest: Jul 07 (Positive)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
Jul 07 AI discovery analysis Positive +1.6% Broad SLC analysis and international AI-driven small-molecule discovery initiative
Jun 29 Solar investment monetization Positive -6.6% Partial Melz investment monetization at a reported $14.5 million project valuation
Jun 22 AI partnership announcement Positive +155.9% MitoCareX and Boltz launched an international SLC small-molecule discovery initiative
Jun 17 SLC analysis completion Positive -8.3% Completed broad structural analysis of human SLC transport proteins
May 18 R&D milestone Positive +10.8% Generated an optimized hit molecule with improved pharmaceutical properties

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

Comparable platform and discovery announcements produced mixed 24-hour reactions, with both alignments and divergences.

Key Terms

slc transport protein, rtb (ready to build)
2 terms
slc transport protein medical
"MitoCareX has narrowed its focus from the broader pool of SLC transport protein candidates"
A SLC transport protein is a member of the solute carrier (SLC) family, a large group of membrane proteins that move molecules such as ions, nutrients, and drugs into and out of cells. Think of them as biological gatekeepers or transport trucks that determine how substances get where they need to go in the body. They matter to investors because they influence drug absorption, distribution, and safety, serve as potential drug targets or biomarkers, and can affect the commercial and regulatory prospects of therapies.
rtb (ready to build) technical
"invests in solar energy assets based on the RTB (Ready to Build) business model"
Land described as "ready to build" has all required permits, approvals and infrastructure in place so construction can begin without delay. For investors, this status is like having a finished recipe and ingredients on the counter: it cuts the time, cost and regulatory uncertainty between purchase and revenue, reducing execution risk and making project timelines and budgets more predictable.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Following its broad structural analysis of the human SLC transport protein family, MitoCareX advances from a pool of candidates to a prioritized target, reflecting continued execution of its MITOLINE®-driven discovery strategy

Ness Ziona, Israel, July 28, 2026 (GLOBE NEWSWIRE) -- Nexentis Technologies Inc. (“Nexentis”), (NASDAQ: NXTS) (“Nexentis” or the “Company”), a drug discovery company that also invests in solar energy assets based on the RTB (Ready to Build) business model, today announced that its wholly owned subsidiary, MitoCareX Bio Ltd. ("MitoCareX"), has narrowed its focus from the broader pool of SLC transport protein candidates previously identified through its structural analysis efforts, selecting a candidate for a drug discovery campaign.

As previously disclosed, MitoCareX's broad structural analysis identified a set of SLC transport proteins outside its mitochondrial program that appeared compatible with the MITOLINE® enabled structural modelling. Building on that work, the Company has now completed an internal prioritization process and identified a candidate supported by favorable characteristics for inclusion in a drug discovery campaign.

"This step reflects continued execution of our drug discovery strategy and tangible progress in translating the breadth of our platform into a focused, actionable pipeline decision," said David Palach, Chief Executive Officer of Nexentis Technologies Inc. "Having previously mapped a broader universe of transport protein candidates, we have now taken the next step of narrowing that pool to a priority candidate. We view this as an important example of how MITOLINE® can systematically convert computational insight into concrete discovery decisions over time."

About MitoCareX Bio Ltd.
MitoCareX Bio Ltd. is a drug discovery company. By combining its proprietary MITOLINE® algorithm and diverse computational tools with specialized biological systems, MitoCareX aims to generate programs in areas of high unmet medical need.

About Nexentis Technologies Inc.
Nexentis Technologies Inc. (NASDAQ: NXTS) owns 100% of MitoCareX Bio Ltd, a drug discovery company. Additionally, Nexentis adopted an investment strategy focused on European renewable energy assets utilizing a RTB (Ready to Build) business model. The Company is currently the lead investor in four solar projects across three European Union countries, all introduced by Solterra Renewable Energy Ltd., a wholly owned subsidiary of Solterra Energy Ltd.

For additional details, please visit https://nexentistech.com/

Forward-looking Statements:
This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses continued execution of its drug discovery strategy and tangible progress in translating the breadth of its platform into a focused, actionable pipeline decision. Because forward-looking statements relate to matters that have not yet occurred, these statements are inherently subject to known and unknown risks, uncertainties and other factors that may cause the Company’s and its subsidiaries’ actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Important factors that could cause actual results, performance or achievements to differ materially from those anticipated in these forward-looking statements include, among other things, our market and other conditions, history of losses and needs for additional capital to fund our operations and our inability to obtain additional capital on acceptable terms, or at all; uncertainties of cash flows and inability to meet working capital needs; the initiation, timing, progress and results of our preclinical studies, clinical trials and other product candidate development efforts; our ability to advance our product candidates into clinical trials or to successfully complete our preclinical studies or clinical trials; our receipt of regulatory approvals for our product candidates, and the timing of other regulatory filings and approvals; the clinical development, commercialization and market acceptance of our product candidates; our ability to establish and maintain strategic partnerships and other corporate collaborations; the implementation of our business model and strategic plans for our business and product candidates; the scope of protection we are able to establish and maintain for intellectual property rights covering our product candidates and our ability to operate our business without infringing the intellectual property rights of others; competitive companies, technologies and our industry; risks related to not satisfying the continued listing requirements of Nasdaq Capital Market; and statements as to the impact of the political and security situation in Israel on our business. More information on these risks, uncertainties and other factors is included from time to time in the “Risk Factors” section of the Company’s Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”) on March 31, 2026 and other public reports filed with the SEC. Except as otherwise required by law, we undertake no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. We are not responsible for the contents of third-party websites.

Investor Relations Contact:
Michal Efraty
michal@efraty.com


FAQ

What did Nexentis Technologies (NASDAQ: NXTS) announce about MitoCareX Bio on July 28, 2026?

Nexentis Technologies reported that MitoCareX Bio selected a prioritized SLC transport protein candidate for a drug discovery campaign. According to Nexentis, this follows broad structural analysis supported by the MITOLINE® platform and an internal prioritization process to identify a target with favorable characteristics.

How does the MITOLINE® platform support Nexentis (NXTS) and MitoCareX Bio’s drug discovery strategy?

MITOLINE® supports drug discovery by enabling structural modelling of selected SLC transport proteins to identify suitable targets. According to Nexentis, the platform helped narrow a broad universe of transport protein candidates into one prioritized target, illustrating how computational insights inform concrete discovery decisions over time.

What is the significance of the SLC transport protein candidate chosen by MitoCareX Bio for Nexentis (NASDAQ: NXTS)?

The chosen SLC transport protein represents a prioritized target for a new drug discovery campaign. According to Nexentis, it marks progression from broad structural analysis to a focused pipeline decision, demonstrating execution of the company’s MITOLINE®-driven discovery strategy beyond its mitochondrial program.

What are Nexentis Technologies’ main business activities besides MitoCareX Bio’s drug discovery work?

Nexentis combines drug discovery with investment in European renewable energy assets using an RTB model. According to Nexentis, it owns 100% of MitoCareX Bio and is lead investor in four solar projects across three EU countries introduced by its partner Solterra Renewable Energy.

How does MitoCareX Bio describe its overall mission within Nexentis Technologies (NXTS)?

MitoCareX Bio describes itself as a drug discovery company using its proprietary MITOLINE® algorithm with computational tools and specialized biological systems. According to Nexentis, MitoCareX aims to generate programs targeting areas of high unmet medical need through this integrated discovery approach.