Onco-Innovations' PKNP Technology Used with Radiation Therapy Shown in Study to Demonstrate Low Toxicity and High Safety Profile
Rhea-AI Summary
Onco-Innovations (ONNVF) has reported positive results from a December 2021 University of Alberta study on its second-generation nanoparticle formulation of Polynucleotide Kinase 3'-Phosphatase (PNKP) Compound used in combination with radiation therapy. The study focused on mice with colorectal cancer tumors, divided into three treatment groups receiving different combinations of treatments over 24 days.
The key finding revealed that the PNKP technology demonstrated effective cancer cell targeting while maintaining a low toxicity profile, even at therapeutic doses. Notably, no significant toxicity signs, including weight loss, were observed in any treatment group, including those receiving PNKP inhibitor-loaded nanoparticles with radiation.
This development is particularly significant as it suggests potential for developing safer cancer treatments with fewer side effects. The technology's minimal toxicity in preclinical animal models aligns with Health Canada's rigorous testing requirements for drug safety assessment.
Positive
- Demonstrated effective cancer cell targeting with low toxicity profile
- No significant side effects observed in preclinical trials
- Successfully passed initial safety testing requirements for Health Canada
Negative
- Still in early preclinical testing phase
- Results to animal studies only
- Further extensive testing required before human trials
News Market Reaction – ONNVF
On the day this news was published, ONNVF declined 31.77%, reflecting a significant negative market reaction.
Data tracked by StockTitan Argus on the day of publication.
VANCOUVER, BC / ACCESS Newswire / March 26, 2025 / Onco-Innovations Limited (CSE:ONCO)(OTCQB:ONNVF)(Frankfurt:W1H, WKN: A3EKSZ) ("Onco" or the "Company") is pleased to provide information regarding its second-generation nanoparticle formulation of Polynucleotide Kinase 3'-Phosphatase (PNKP) Compound (the "Technology") in combination with radiation therapy, which has demonstrated, in a December 2021 study[1] conducted by researchers at the University of Alberta, Canada, effective targeting of cancer cells in mice while, importantly, maintaining a low toxicity profile. The low toxicity observed in the study, even at therapeutic doses in mice with colorectal cancer, and especially when combined with radiation therapy, is particularly significant, as it suggests the potential for a solution with fewer side effects, which could lead to the development of safer and more effective treatment options.
As part of the study, mice implanted with colorectal cancer tumours (HCT116/PTEN+/+ tumours) were divided into three groups and received three separate injections over a 24-day period. Treatment groups included those receiving empty nanoparticles, empty nanoparticles with radiation, and PNKP inhibitor-loaded nanoparticles with radiation. Throughout the study, no significant signs of toxicity such as weight loss were detected in any group, including those treated with the nanoparticle formulation of the PNKP inhibitor in conjunction with radiation. [2]
A key factor in developing safer and more effective cancer treatments is ensuring a low toxicity profile. Onco's Technology has demonstrated minimal toxicity in preclinical animal models, which suggests its potential for use in advancing therapies that cause fewer side effects. In compliance with Health Canada regulations, drugs must undergo rigorous testing in both animal models (in vivo) and cell cultures (in vitro) to assess their safety and toxicity at doses aimed at achieving therapeutic effects.
"Establishing the safety of combination therapies is an important step in advancing cancer treatment. The findings from this study reinforce the strong safety profile of our PNKP technology in animal testing when used alongside radiation therapy. With low toxicity being a key factor in treatment development, these results provide a solid foundation for future research as we continue exploring the potential of this approach in upcoming studies," said Thomas O'Shaughnessy, CEO of the Company.
About Onco-Innovations Limited
Onco-Innovations is a Canadian-based company dedicated to cancer research and treatment, specializing in oncology. Onco's mission is to prevent and cure cancer through pioneering research and innovative solutions. The company has secured an exclusive worldwide license to patented technology that targets solid tumours, setting new standards in cancer treatment. Onco's commitment to excellence and innovation drives it to develop advanced therapies that improve patient outcomes and offer hope in the fight against cancer.
ON BEHALF OF ONCO-INNOVATIONS LIMITED,
"Thomas O'Shaughnessy"
Chief Executive Officer
For more information, please contact:
Thomas O'Shaughnessy
Chief Executive Officer
Tel: + 1 888 261 8055
investors@oncoinnovations.com
The CSE and Information Service Provider have not reviewed and do not accept responsibility for the accuracy or adequacy of this release.
Forward-Looking Statements Caution. This news release contains forward-looking statements relating to the further development, potential commercialization and benefits of the Technology, and the prospects of the Company, and the Company's business and plans generally, and other statements that are not historical facts. Forward-looking statements are often identified by terms such as "will", "may", "potential", "should", "anticipate", "expects" and similar expressions. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company's expectations include the failure to further develop, prove out or commercialize the Technology, the failure to receive regulatory approval in respect of the Technology, and other risks detailed from time to time in the filings made by the Company with securities regulators. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements as expressly required by applicable law.
[1] Sadat et al. Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage. Front Oncol. 2021 Dec 23;11:772920. doi: 10.3389/fonc.2021.772920
[2] Sadat et al. Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage. Front Oncol. 2021 Dec 23;11:772920. doi: 10.3389/fonc.2021.772920
SOURCE: Onco-Innovations Limited
View the original press release on ACCESS Newswire
FAQ
What were the key findings of the University of Alberta study on ONNVF's PNKP technology?
How was the ONNVF PNKP study conducted on mice with colorectal cancer?
What makes ONNVF's PNKP technology potentially significant for cancer treatment?
When was the ONNVF PNKP technology study conducted and by whom?
