Cocrystal Pharma Announces $5 Million Private Placement with OPKO Health
Rhea-AI Summary
Cocrystal Pharma (Nasdaq: COCP) entered into a $5 million private placement with longtime investor OPKO Health (Nasdaq: OPK). Cocrystal sold 5,474,053 common shares to OPKO at $0.9134 per share, equal to the Nasdaq Consolidated Bid Price on the closing day, with no warrants or other derivatives issued.
According to Cocrystal, the proceeds support advancement of its lead norovirus candidate CDI-988, with topline Phase 1b data expected by the end of the fourth quarter of 2026. Both companies highlighted OPKO’s longstanding support and confidence in Cocrystal’s antiviral pipeline.
Positive
- $5.0 million gross proceeds from OPKO Health private placement
- Issued 5,474,053 common shares with no warrants or derivatives attached
- Share price set at Nasdaq Consolidated Bid Price of $0.9134
- Funding tied to advancing CDI-988 toward Phase 1b topline data by Q4 2026
Negative
- Issuance of 5,474,053 new shares creates equity dilution for existing shareholders
News Explained
The closed sale changes existing holders’ proportional ownership while adding five million dollars of company proceeds.
The announced private placement is closed: Cocrystal Pharma sold
A private placement is a sale of securities to selected investors outside a public offering; here, the disclosed security was common stock, with no warrants or other derivative securities.
The
Sources and calculations
- Cocrystal Pharma Announces $5 Million Private Placement with OPKO Health (2026-08-03)
- Private placement / PIPE (2026-07-17)
- Cocrystal Pharma 2026 first-quarter fundamentals (2026Q1)
- Offering gross vs quarterly operating cash outflow, in days of cash use $5,000,000 / ($2,340,000 / 90) = [object Object]
- Cash and equivalents vs quarterly operating cash outflow, in days of cash use $4,685,000 / ($2,340,000 / 90) = [object Object]
Market Reaction – OPK
Following this news, OPK has declined 0.30%, reflecting a mild negative market reaction. The stock is currently trading at $1.32.
Data tracked by StockTitan Argus (15 min delayed). Upgrade to Gold for real-time data.
Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Jul 27 | Q2 earnings report | Positive | +33.1% | Revenue growth, narrower losses, and 2026 guidance accompanied the quarterly results. |
| Jul 23 | Earnings date notice | Neutral | -0.8% | The company scheduled its Q2 results release and investor conference call. |
| Jun 15 | Preclinical data presentation | Positive | -1.4% | Preclinical studies showed sustained IGF-1 suppression and stronger receptor antagonism. |
| May 12 | Preclinical data presentation | Positive | -1.8% | Animal studies demonstrated in vivo CAR-T generation and systemic B-cell depletion. |
| Apr 30 | Partnership expansion | Positive | +1.4% | The amended agreement expanded RAYALDEE commercialization in Greater China. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
OPK's prior news reactions were mixed: positive earnings aligned with a 33.06% gain, while preclinical and scheduling items diverged with negative reactions.
Key Terms
private placement financial
phase 1b medical
topline data medical
derivative securities financial
AI-generated analysis. How Rhea-AI works. Not financial advice.
Longtime investor OPKO Health increases its position as Cocrystal advances toward norovirus Phase 1b data in late 2026
BOTHELL, Wash., Aug. 03, 2026 (GLOBE NEWSWIRE) -- Cocrystal Pharma, Inc. (Nasdaq: COCP) ("Cocrystal" or the "Company"), a biotechnology company developing novel antiviral therapeutics, today announced a
Under the terms of the agreement, Cocrystal sold 5,474,053 shares of its common stock to OPKO at a price per share of
“OPKO’s increased investment reflects the confidence of one of our most steadfast supporters as we approach a defining moment for Cocrystal,” said James Sapirstein, Chief Executive Officer of Cocrystal Pharma. “We expect to report topline data from our Phase 1b norovirus trial by the end of the fourth quarter of 2026, and we’re grateful for OPKO’s continued conviction in the value of our lead asset, CDI-988, and our broader antiviral pipeline spanning influenza, coronaviruses and hepatitis C.”
“As a longtime investor in Cocrystal, we’ve watched the Company build a differentiated antiviral platform with real clinical potential,” said Dr. Phillip Frost, Chairman and Chief Executive Officer of OPKO Health and co-founder, director and principal stockholder of the Company. “This additional investment reflects our continued conviction in Cocrystal’s science and its path forward.”
About the Offering
The unregistered securities described above were offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and Regulation D promulgated thereunder and have not been registered under the Securities Act, or applicable state securities laws. Accordingly, the unregistered shares may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Securities Act and such applicable state securities laws.
This press release does not constitute an offer to sell or a solicitation of an offer to buy any securities, nor will there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.
About Cocrystal Pharma, Inc.
Cocrystal Pharma, Inc. is a clinical stage biotechnology company discovering and developing novel antiviral therapeutics that target the replication of noroviruses, influenza viruses, coronaviruses (including SARS-CoV-2), and hepatitis C viruses. The Company’s lead program, CDI-988, is currently in a Phase 1b clinical trial for norovirus, with topline data expected in late 2026. Cocrystal employs unique structure-based technologies to create differentiated antiviral drug candidates. For more information, visit www.cocrystalpharma.com.
About OPKO Health, Inc.
OPKO is a multinational biopharmaceutical and diagnostics company that seeks to establish industry leading positions in large, rapidly growing markets by leveraging its discovery, development, and commercialization expertise and novel and proprietary technologies. For more information, visit www.opko.com.
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding the private placement, the Company's progress, anticipated timeline and expectations for topline data from its norovirus Phase 1b clinical trial, and the continued development of its influenza, coronaviruses, and hepatitis C, and other antiviral programs and the results thereof. Words such as "believe," "may," "estimate," "continue," "anticipate," "intend," "should," "plan," "could," "target," "potential," "is likely," "will," and "expect," as they relate to the Company, are intended to identify forward-looking statements. We have based these forward-looking statements largely on our current expectations and projections about future events. Some or all of the events anticipated by these forward-looking statements may not occur. Important factors that could cause actual results to differ from those in the forward-looking statements include, but are not limited to, the risks and uncertainties arising from inflation, affordability, the possibility of a recession, increases or other developments with respect to interest rates, uncertainty surrounding the impacts arising from imposed and threatened tariffs and developments with respect thereto, and wars and geopolitical conflicts including those in Ukraine and with Iran on our Company, our collaboration partners, and on the U.S. and global economies, including manufacturing and research delays arising from raw materials and labor shortages, supply chain disruptions and other business interruptions including any adverse impacts on our ability to obtain raw materials and test subjects, including animals as well as similar problems with our vendors our and our collaboration partners’ technology and software performing as expected, financial difficulties experienced by certain partners, risks arising from research into a related virus that was not done in animals and was necessarily early stage, the results of the Phase 1b clinical trial and future preclinical and clinical trials including the potential for adverse findings, general risks arising from clinical trials, receipt of regulatory approvals, regulatory changes and potential litigation challenging initiatives and actions taken by the Trump Administration which could, among other things, result in delays in regulatory approvals or limit access to federal funding for our programs, development of effective treatments and/or vaccines by competitors, including as part of the programs financed by the U.S. government, potential mutations in a virus we are targeting which may result in variants that are resistant to a product candidate we develop, and our liquidity and ability to raise necessary capital on acceptable terms or at all. Further information on our risk factors is contained in our filings with the SEC, including the “Risk Factors” in Item 1A of our Annual Report on Form 10-K for the year ended December 31, 2025. Any forward-looking statement made by us herein speaks only as of the date on which it is made. Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. We undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by law.
Investor Contact:
Nic Johnson
Russo Partners
nic.johnson@russopartnersllc.com
(303) 482-6405
Media Contact:
David Schull
Russo Partners
david.schull@russopartnersllc.com
(858) 717-2310
