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ORIC Pharmaceuticals, Inc. develops clinical-stage oncology therapies designed to counter mechanisms of therapeutic resistance in cancer. News about ORIC commonly covers rinzimetostat (ORIC-944), a selective allosteric PRC2/EED inhibitor studied in prostate cancer and metastatic castration-resistant prostate cancer, and enozertinib (ORIC-114), a brain-penetrant selective inhibitor targeting EGFR exon 20 insertion mutations and EGFR atypical mutations.
Recurring updates include clinical and preclinical data presentations, development-dose decisions, oncology conference presentations, quarterly financial results, cash runway disclosures, at-the-market equity financing, and Nasdaq Rule 5635(c)(4) inducement equity grants.
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ORIC Pharmaceuticals, a clinical-stage oncology company, announced participation in a fireside chat at the H.C. Wainwright BioConnect Investor Conference on May 2, 2023, at 2:00 p.m. ET. The event will be accessible via a live webcast on the company’s website, with a replay available for 90 days post-event.
ORIC focuses on developing treatments that address mechanisms of therapeutic resistance, with product candidates including ORIC-533 for multiple myeloma, ORIC-114 targeting genetically defined cancers, and ORIC-944 for prostate cancer. The company operates from South San Francisco and San Diego, California.
ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC), a clinical-stage oncology company, presented two preclinical posters at the 2023 AACR Annual Meeting. These presentations highlight the company’s ongoing development of ORIC-944, a PRC2 inhibitor currently in Phase 1 clinical trials targeting metastatic prostate cancer, and progress in their PLK4 inhibitor program aimed at addressing specific breast cancer mechanisms.
The findings revealed that ORIC-944 lowers H3K27me3 levels, supporting its biomarker strategy for the ongoing trial. In the PLK4 program, selective inhibitors exhibited synthetic lethality in TRIM37-amplified cancers. Both programs demonstrate ORIC's commitment to advancing targeted therapies against cancer resistance mechanisms.
ORIC Pharmaceuticals reported significant advancements in its clinical pipeline, driven by three ongoing Phase 1b trials: ORIC-533 for multiple myeloma, ORIC-114 for EGFR/HER2-mutated cancers, and ORIC-944 for prostate cancer. A $25 million equity investment from Pfizer was secured, alongside a collaboration for a potential Phase 2 study of ORIC-533. As of December 31, 2022, the company had $228.2 million in cash and investments, expected to fund operations into the first half of 2025. The R&D expenses for 2022 totaled $61.7 million, reflecting strategic investments in product development.
ORIC Pharmaceuticals (Nasdaq: ORIC) announced two accepted abstracts for poster presentations at the 2023 AACR Annual Meeting, scheduled for April 14-19, 2023. The presentations will showcase preclinical biomarker results for ORIC-944, a selective PRC2 inhibitor in Phase 1 trials for metastatic prostate cancer, and data from its PLK4 inhibitor program. The biomarker strategy for ORIC-944 indicates significant H3K27me3 level reductions in response to treatment. Additionally, selective PLK4 inhibition shows enhanced synthetic lethality in certain cancer models. Both presentations aim to underline ORIC's innovative approach to overcoming therapeutic resistance.