Pharming Group reports first quarter 2025 financial results and provides business update
- Total revenues increased 42% YoY to US$79.1 million
- RUCONEST® revenue grew 49% YoY to US$68.6 million with 37% increase in U.S. unit sales volume
- Joenja® revenue up 9% with 18% volume increase and 102 patients on paid therapy
- Raised 2025 revenue guidance to US$325-340 million
- Achieved operating profit of US$0.8 million vs US$16.3 million loss in Q1 2024
- Targeting 15% or $10 million annual reduction in G&A expenses
- Higher gross-to-net adjustments affected Joenja® revenue growth
- Cash position decreased from US$169.4 million to US$108.9 million
- CFO Jeroen Wakkerman leaving the company
- Reported net loss of US$14.9 million for Q1 2025
Insights
Pharming delivers 42% revenue growth, returns to adjusted operating profitability, raises guidance while advancing clinical pipeline and integrating acquisition.
Pharming Group's Q1 2025 results demonstrate exceptional commercial momentum, with total revenue surging
The company achieved an adjusted operating profit of
Management's decision to raise 2025 revenue guidance to
For Joenja®, the patient base continues expanding with 102 patients on paid therapy in the U.S. (
The Abliva acquisition (
The announced departure of CFO Jeroen Wakkerman, following the recent CEO transition, creates some leadership uncertainty, though a search for a successor is underway.
- First quarter 2025 total revenues increased by
42% to US$79.1 million , compared to the first quarter 2024 - RUCONEST® revenue increased by
49% to US$68.6 million , compared to the first quarter 2024, reflecting continued momentum and the product’s unique position in the on-demand HAE market - Joenja® (leniolisib) volume increase by
18% and revenue increased by9% to US$10.5 million , compared to the first quarter of 2024, with accelerating patient uptake compared to the prior few quarters - Operating profit, adjusted to exclude the impact of non-recurring Abliva acquisition-related expenses, amounted to US
$0.8 million compared to a US$16.3 million loss in the first quarter 2024 - Launched Joenja® (leniolisib) in England and Wales in April and preparing to file for U.S. FDA approval for pediatrics in the third quarter 2025
- Completed the acquisition of Abliva AB during the quarter and, in April, promptly started the second wave of recruitment for the pivotal FALCON clinical trial in mitochondrial DNA-driven primary mitochondrial diseases
- 2025 total revenue guidance raised to US
$325 - US$340 million , up from prior US$315 - US$335 million - Announces that Jeroen Wakkerman, Chief Financial Officer, will leave Pharming at the end of the month, to pursue other opportunities
- Pharming to host a conference call today at 13:30 CEST (7:30 am EDT)
Leiden, the Netherlands, May 8, 2025: Pharming Group N.V. (“Pharming” or “the Company”) (Euronext Amsterdam: PHARM / Nasdaq: PHAR) presents its preliminary unaudited financial report for the three months ended March 31, 2025.
Chief Executive Officer, Fabrice Chouraqui commented:
“We ended 2024 with great momentum, and 2025 has started on an even stronger note. First quarter RUCONEST® revenue increased by
Our efforts to make Joenja® available to additional APDS patients are bearing fruit. We launched Joenja® in England and Wales in late April following a positive reimbursement decision from NICE and we received our fourth country regulatory approval in Australia. We are preparing to file for U.S. FDA approval for pediatrics in the third quarter and potentially launch in the first quarter of 2026.
We are making strong progress advancing high value programs in our pipeline. Patient enrollment is on track in both proof of concept trials studying leniolisib in larger PID indications. In addition, approximately a month after completing the Abliva acquisition, we successfully started the second wave of patient recruitment in the pivotal FALCON clinical trial for KL1333 in primary mitochondrial diseases, achieving a key milestone in our integration plan.
I would like to thank Jeroen Wakkerman for his contributions to the growth of Pharming and the development of the Finance team over the past four years. We have initiated a search for a new CFO to lead our financial strategy going forward.
Overall, this strong quarter is another illustration of our execution capabilities and future growth prospects. We look forward to providing future updates on our significant upcoming near- and long-term catalysts.”
First quarter 2025 highlights
Commercialized products
RUCONEST® marketed for the treatment of acute HAE attacks
RUCONEST® demonstrated significant strength in the first quarter of 2025, with revenues of US
The U.S. market contributed
The strong performance was mainly driven by the continued increase in prescribers and patients on therapy in the U.S. We achieved over 90 new patient enrollments in the U.S. in the first quarter, demonstrating continued strength in underlying in-market demand for RUCONEST®. Unit sales volume in the U.S. increased by
Joenja® (leniolisib) marketed for the treatment of APDS
Joenja® revenues increased to US
The U.S. market contributed
As of March 31, 2025, we had 102 patients on paid therapy in the U.S., representing a
We launched Joenja® in the U.K. in April. On April 23, 2025 the National Institute for Health and Care Excellence (NICE) issued positive final guidance recommending Joenja® (leniolisib) for reimbursement and use within the National Health Service (NHS) in England and Wales for the treatment of APDS in adult and pediatric patients 12 years of age and older. Leniolisib is now available for use and funded in England through the Innovative Medicines Fund, ensuring immediate patient access. In Wales, leniolisib is expected to be funded starting in July through the NHS in specialist centers.
APDS patient finding
We have now identified approximately 250 APDS patients in the U.S., including over 160 patients 12 years of age or older who are eligible for treatment with Joenja®, demonstrating progress finding additional patients. As of December 31, 2024, we had identified over 880 diagnosed APDS patients worldwide.
APDS patient finding - VUS reclassification
There are currently over 1,300 patients in the U.S. with a Variant of Uncertain Significance, or VUS, in the PIK3CD or PIK3R1 genes. As previously communicated, an in vitro high throughput screening study was completed in the fourth quarter of 2024, identifying many novel variants leading to PI3Kδ hyperactivity. We expect the results of this study to be published shortly, and clinical genetics laboratories in the U.S. are undertaking efforts to reclassify variants they deem to be disease-causing and thus issue amended genetic testing reports with an APDS diagnosis for many of the VUS patients. We anticipate that these initiatives will lead to the identification of new patients with APDS eligible for therapy with Joenja®, adding an additional growth lever during the second half of 2025.
Joenja® (leniolisib) development
In total, there are currently 204 patients in a leniolisib Expanded Access Program (compassionate use), an ongoing clinical study, or a named patient program, of whom 187 are APDS patients.
Leniolisib for APDS
Pediatric clinical development
On May 2, 2025, positive clinical results from the multinational Phase III clinical trial evaluating leniolisib tablets in children 4 to 11 years of age with APDS were presented at the 2025 Annual Meeting of the Clinical Immunology Society (CIS) in Philadelphia, PA. The data are consistent with the improvements seen in the previously reported randomized controlled trial in adolescent and adult APDS patients. Based on U.S. FDA feedback, we plan to submit a regulatory filing for pediatric label expansion in the U.S. in the third quarter of 2025.
In April 2025, the Phase III pediatric clinical trial evaluating a new pediatric formulation of leniolisib in children 1 to 6 years of age completed enrollment with 16 patients.
Japan
We are on track to submit a regulatory filing with Japan’s Pharmaceuticals and Medical Devices Agency (PMDA) in mid-2025. An approval decision would be expected nine months later based on priority review of the application due to orphan drug designation (ODD) by the Ministry of Health, Labour and Welfare of Japan (MHLW) for the treatment of APDS.
European Economic Area (EEA)
In regard to the ongoing review of the leniolisib Marketing Authorisation Application (MAA) for the treatment of adult and pediatric patients 12 years of age and older, we are on track to complete the manufacturing activities requested by the European Medicines Agency’s (EMA) Committee for Human Medicinal Products (CHMP) and submit a response by the January 2026 deadline.
Additional markets
Joenja® was approved in Israel in 2024 and in Australia in March 2025, with reimbursement discussions/negotiations ongoing with government payors in both countries.
Regulatory reviews are ongoing for APDS patients 12 years of age and older in Canada and Saudi Arabia, with decisions expected in 2026, and South Korea, where we filed a regulatory submission in March 2025.
Leniolisib for additional primary immunodeficiencies (PIDs)
We are developing leniolisib for additional primary immunodeficiencies, or PIDs, which affect significantly more patients than APDS. These include (i) genetically identifiable PIDs with immune dysregulation linked to altered PI3Kδ signaling and (ii) common variable immunodeficiency, or CVID, with immune dysregulation identified independently of genetics. Leniolisib, by modulating PI3Kδ activity, could help in the treatment of PID patients with immune dysregulation, positively impacting their clinical manifestations of autoimmunity and end-organ lympho-infiltrative disease.
We started a Phase II clinical trial evaluating leniolisib for PIDs with immune dysregulation linked to altered PI3Kẟ signaling in October 2024, and a Phase II clinical trial for CVID with immune dysregulation in February 2025. We initiated patient dosing in the CVID study in March 2025. Enrollment in both clinical trials is proceeding as planned.
Acquisition of Abliva AB
We completed the acquisition of Abliva AB, via a public cash offer to the shareholders to acquire all issued and outstanding shares for approximately US
The acquisition was accounted for as a business combination with substantially all of the value of the acquisition concentrated in a single asset, KL1333. The acquisition is reflected in our first quarter financial statements, with the acquisition price allocated to the fair value of the acquired identifiable assets and liabilities and the excess recorded as goodwill.
KL1333 for mitochondrial DNA-driven primary mitochondrial disease
We started the second wave of patient recruitment for the pivotal FALCON clinical trial in April 2025. The FALCON clinical trial is studying KL1333 in adult patients with genetically confirmed primary mitochondrial disease (PMD) with mitochondrial DNA (mtDNA) mutations who experience consistent, debilitating fatigue and muscle weakness (myopathy), and reduced life expectancy. We continue to anticipate trial read-out in 2027 with potential FDA approval by end of 2028.
Organizational updates
On January 21, 2025, we announced that the Board of Directors had nominated biopharmaceutical leader Mr. Fabrice Chouraqui as Pharming’s new Chief Executive Officer and Executive Director, succeeding Mr. Sijmen de Vries.
Mr. Chouraqui was appointed for a term of four years at the Extraordinary General Meeting of Shareholders on March 4, 2025. Upon the appointment of Mr. Chouraqui, Mr. de Vries resigned from the Board of Directors. To ensure a smooth hand-over of tasks and responsibilities, Mr. de Vries will remain a strategic advisor to the new CEO until December 31, 2025.
We announce today that Mr. Jeroen Wakkerman will leave as Chief Financial Officer on May 31, 2025, to pursue other opportunities. A search for a successor is underway, and an interim head of finance and IT has been appointed to ensure a seamless transition.
Financial summary
| Consolidated Statement of Income | 1Q 2025 | 1Q 2024 |
| Amounts in US$m except per share data | ||
| Total Revenues | 79.1 | 55.6 |
| Cost of sales | (8.3) | (8.4) |
| Gross profit | 70.8 | 47.2 |
| Other income | 0.4 | 0.3 |
| Research and development | (21.1) | (18.5) |
| General and administrative | (22.5) | (15.1) |
| Marketing and sales | (34.6) | (30.2) |
| Other Operating Costs | (78.2) | (63.8) |
| Operating profit (loss) | (7.0) | (16.3) |
| Other finance income | 0.6 | 1.8 |
| Other finance expenses | (5.1) | (1.6) |
| Share of net profits in associates using the equity method | (0.3) | (0.5) |
| Profit (loss) before tax | (11.8) | (16.6) |
| Income tax credit (expense) | (3.1) | 4.2 |
| Profit (loss) for the period | (14.9) | (12.4) |
| Earnings per share | ||
| Basic, attributable to equity holders of the parent (US$) | (0.022) | (0.019) |
| Diluted, attributable to equity holders of the parent (US$) | (0.022) | (0.019) |
| Segment information - Revenues | 1Q 2025 | 1Q 2024 |
| Amounts in US$m | ||
| Revenue - RUCONEST® (US) | 66.6 | 44.8 |
| Revenue - RUCONEST® (EU and RoW) | 2.0 | 1.2 |
| Total Revenues - RUCONEST® | 68.6 | 46.0 |
| Revenue - Joenja® (US) | 9.5 | 8.5 |
| Revenue - Joenja® (EU and RoW) | 1.0 | 1.1 |
| Total Revenues - Joenja® | 10.5 | 9.6 |
| Total Revenues - US | 76.1 | 53.3 |
| Total Revenues - EU and RoW | 3.0 | 2.3 |
| Total Revenues | 79.1 | 55.6 |
| Consolidated Balance Sheet | March 31, 2025 | December 31, 2024 |
| Amounts in US$m | ||
| Cash and cash equivalents, restricted cash and marketable securities | 108.9 | 169.4 |
| Current assets | 214.1 | 278.4 |
| Total assets | 403.2 | 400.0 |
| Current liabilities | 77.5 | 73.8 |
| Shareholders' equity | 214.0 | 221.1 |
Financial highlights
On February 14, 2025, the company gained control of Abliva AB by acquiring
Total revenues for the first quarter of 2025 increased by
Gross profit increased by
The operating loss amounted to US
The Company had a net loss of US
Outlook/Summary
For 2025, the Company anticipates:
- Total revenues between US
$325 million and US$340 million (9% to14% growth), with quarterly fluctuations expected. - Total operating expenses not to exceed the prior year pre-Abliva impact and we expect US
$30 million in Abliva-related operating expenses, including research and development and non-recurring transaction and integration expenses. - Significant progress finding additional APDS patients in the U.S., supported by VUS validation efforts and subsequently converting patients to paid Joenja® (leniolisib) therapy.
- Increasing ex-U.S. revenues for leniolisib - driven by funded access programs and commercial availability in the U.K.
- Progress towards additional regulatory approvals for leniolisib for APDS patients 12 years of age or older, and submitting regulatory filings in Japan and for pediatric label expansion in key global markets.
- Advancing the two ongoing Phase II clinical trials in PIDs with immune dysregulation to significantly expand the long-term commercial potential of leniolisib.
- Advancing the ongoing pivotal FALCON clinical study for KL1333 in mitochondrial DNA-driven primary mitochondrial diseases.
- Continued focus on potential acquisitions and in-licensing of clinical stage opportunities in rare diseases.
No further specific financial guidance for 2025 is provided.
Additional information
Presentation
The conference call presentation is available on the Pharming.com website from 07:30 CEST today.
Conference Call
The conference call will begin at 13:30 CEST / 07:30 EDT on Thursday, May 8. A transcript will be made available on the Pharming.com website in the days following the call.
Please note, the Company will only take questions from dial-in attendees.
Webcast Link:
https://edge.media-server.com/mmc/p/y45rvzpj
Conference call dial-in details:
https://register-conf.media-server.com/register/BI1059030b794549a5a265dac1ee0542eb
Additional information on how to register for the conference call/webcast can be found on the
Pharming.com website.
Financial Calendar 2025
Annual General Meeting of Shareholders June 11
2Q/1H 2025 financial results July 31
3Q 2025 financial results November 6
For further public information, contact:
Pharming Group N.V., Leiden, the Netherlands
Michael Levitan, VP Investor Relations & Corporate Communications
T: +1 (908) 705 1696
E: investor@pharming.com
FTI Consulting, London, UK
Simon Conway/Alex Shaw/Amy Byrne
T: +44 203 727 1000
LifeSpring Life Sciences Communication, Amsterdam, the Netherlands
Leon Melens
T: +31 6 53 81 64 27
E: pharming@lifespring.nl
About Pharming Group N.V.
Pharming Group N.V. (EURONEXT Amsterdam: PHARM/Nasdaq: PHAR) is a global biopharmaceutical company dedicated to transforming the lives of patients with rare, debilitating, and life-threatening diseases. We are commercializing and developing a portfolio of innovative medicines, including small molecules and biologics. Pharming is headquartered in Leiden, the Netherlands, and has employees around the globe who serve patients in over 30 markets in North America, Europe, the Middle East, Africa, and Asia-Pacific.
For more information, visit www.pharming.com and find us on LinkedIn.
Forward-looking Statements
This press release may contain forward-looking statements. Forward-looking statements are statements of future expectations that are based on management’s current expectations and assumptions and involve known and unknown risks and uncertainties that could cause actual results, performance, or events to differ materially from those expressed or implied in these statements. These forward-looking statements are identified by their use of terms and phrases such as “aim”, “ambition”, ‘‘anticipate’’, ‘‘believe’’, ‘‘could’’, ‘‘estimate’’, ‘‘expect’’, ‘‘goals’’, ‘‘intend’’, ‘‘may’’, “milestones”, ‘‘objectives’’, ‘‘outlook’’, ‘‘plan’’, ‘‘probably’’, ‘‘project’’, ‘‘risks’’, “schedule”, ‘‘seek’’, ‘‘should’’, ‘‘target’’, ‘‘will’’ and similar terms and phrases. Examples of forward-looking statements may include statements with respect to timing and progress of Pharming's preclinical studies and clinical trials of its product candidates, Pharming's clinical and commercial prospects, and Pharming's expectations regarding its projected working capital requirements and cash resources, which statements are subject to a number of risks, uncertainties and assumptions, including, but not limited to the scope, progress and expansion of Pharming's clinical trials and ramifications for the cost thereof; and clinical, scientific, regulatory, commercial, competitive and technical developments. In light of these risks and uncertainties, and other risks and uncertainties that are described in Pharming's 2024 Annual Report and the Annual Report on Form 20-F for the year ended December 31, 2024, filed with the U.S. Securities and Exchange Commission, the events and circumstances discussed in such forward-looking statements may not occur, and Pharming's actual results could differ materially and adversely from those anticipated or implied thereby. All forward-looking statements contained in this press release are expressly qualified in their entirety by the cautionary statements contained or referred to in this section. Readers should not place undue reliance on forward-looking statements. Any forward-looking statements speak only as of the date of this press release and are based on information available to Pharming as of the date of this release. Pharming does not undertake any obligation to publicly update or revise any forward-looking statement as a result of new information, future events or other information.
Inside Information
This press release relates to the disclosure of information that qualifies, or may have qualified, as inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation.
Pharming Group N.V.
Condensed Consolidated Interim Financial Statements in US Dollars (unaudited)
For the period ended March 31, 2025
- Condensed consolidated statement of income
- Condensed consolidated statement of comprehensive income
- Condensed consolidated balance sheet
- Condensed consolidated statement of changes in equity
- Condensed consolidated statement of cash flow
| CONDENSED CONSOLIDATED STATEMENT OF INCOME | ||
| For the period ended March 31 | ||
| Amounts in US$ ‘000 | 1Q 2025 | 1Q 2024 |
| Revenues | 79,094 | 55,586 |
| Costs of sales | (8,323) | (8,386) |
| Gross profit | 70,771 | 47,200 |
| Other income | 383 | 345 |
| Research and development | (21,142) | (18,521) |
| General and administrative | (22,486) | (15,087) |
| Marketing and sales | (34,570) | (30,249) |
| Other Operating Costs | (78,198) | (63,857) |
| Operating profit (loss) | (7,044) | (16,312) |
| Other finance income | 604 | 1,779 |
| Other finance expenses | (5,098) | (1,556) |
| Finance result, net | (4,494) | 223 |
| Share of net profits (loss) in associates using the equity method | (250) | (535) |
| Profit (loss) before tax | (11,788) | (16,624) |
| Income tax credit (expense) | (3,100) | 4,176 |
| Profit (loss) for the period | (14,888) | (12,448) |
| Attributable to: | ||
| Equity holders of the parent | (14,719) | (12,448) |
| Non-controlling interests | (169) | — |
| Earnings per share | ||
| Basic, attributable to equity holders of the parent (US$) | (0.022) | (0.019) |
| Diluted, attributable to equity holders of the parent (US$) | (0.022) | (0.019) |
| CONDENSED CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME | ||
| For the period ended March 31 | ||
| Amounts in US$ ‘000 | 1Q 2025 | 1Q 2024 |
| Profit (loss) for the period | (14,888) | (12,448) |
| Currency translation differences | 8,931 | (3,734) |
| Items that may be subsequently reclassified to profit or loss | 8,931 | (3,734) |
| Fair value remeasurement investments | — | 51 |
| Items that shall not be subsequently reclassified to profit or loss | — | 51 |
| Other comprehensive income (loss), net of tax | 8,931 | (3,683) |
| Total comprehensive income (loss) for the period | (5,957) | (16,131) |
| Attributable to: | ||
| Equity holders of the parent | (5,788) | (16,131) |
| Non-controlling interests | (169) | — |
| CONDENSED CONSOLIDATED BALANCE SHEET | ||
| Amounts in US$ ‘000 | March 31, 2025 | December 31, 2024 |
| Non-current assets | ||
| Intangible assets | 138,863 | 61,039 |
| Property, plant and equipment | 7,770 | 7,752 |
| Right-of-use assets | 16,457 | 16,382 |
| Long-term prepayments | 94 | 90 |
| Deferred tax assets | 18,390 | 30,544 |
| Investment accounted for using the equity method | 672 | 466 |
| Investments in equity instruments designated as at FVTOCI | 1,311 | — |
| Investment in debt instruments designated as at FVTPL | 3,939 | 3,767 |
| Restricted cash | 1,579 | 1,505 |
| Total non-current assets | 189,075 | 121,545 |
| Current assets | ||
| Inventories | 59,346 | 55,724 |
| Trade and other receivables | 47,487 | 54,823 |
| Marketable securities | 47,180 | 112,949 |
| Cash and cash equivalents | 60,093 | 54,944 |
| Total current assets | 214,106 | 278,440 |
| Total assets | 403,181 | 399,985 |
| Equity | ||
| Share capital | 7,806 | 7,769 |
| Share premium | 490,301 | 488,990 |
| Other reserves | 8,692 | (209) |
| Accumulated deficit | (292,801) | (275,489) |
| Shareholders’ equity | 213,998 | 221,061 |
| Non-controlling interests | 1,292 | — |
| Total equity | 215,290 | 221,061 |
| Non-current liabilities | ||
| Convertible bonds | 83,849 | 78,154 |
| Lease liabilities | 26,506 | 26,968 |
| Total non-current liabilities | 110,355 | 105,122 |
| Current liabilities | ||
| Convertible bonds | 4,555 | 4,245 |
| Trade and other payables | 68,748 | 66,611 |
| Lease liabilities | 4,233 | 2,946 |
| Total current liabilities | 77,536 | 73,802 |
| Total equity and liabilities | 403,181 | 399,985 |
| CONDENSED CONSOLIDATED STATEMENT OF CHANGES IN EQUITY | |||||||
| For the period ended March 31 | |||||||
| Attributable to owners of the parent | |||||||
| Amounts in US$ ‘000 | Share capital | Share premium | Other reserves | Accumulated deficit | Total | Non-controlling interests | Total equity |
| Balance at January 1, 2024 | 7,669 | 478,431 | (2,057) | (265,262) | 218,781 | — | 218,781 |
| Profit (loss) for the period | — | — | — | (12,448) | (12,448) | — | (12,448) |
| Reserves | — | — | 1,770 | (1,770) | — | — | — |
| Other comprehensive income (loss) for the period | — | — | (3,683) | — | (3,683) | — | (3,683) |
| Total comprehensive income (loss) for the period | — | — | (1,913) | (14,218) | (16,131) | — | (16,131) |
| Other reserves | — | — | (31) | 31 | — | — | — |
| Income tax benefit from excess tax deductions related to share-based payments | — | — | — | (16) | (16) | — | (16) |
| Share-based compensation | — | — | — | 2,427 | 2,427 | — | 2,427 |
| Options exercised / LTIP shares issued | 12 | 1,226 | — | (354) | 884 | — | 884 |
| Acquisition of a subsidiary | — | — | — | — | — | — | — |
| Acquisition of non-controlling interests | — | — | — | — | — | — | — |
| Total transactions with owners, recognized directly in equity | 12 | 1,226 | (31) | 2,088 | 3,295 | — | 3,295 |
| Balance at March 31, 2024 | 7,681 | 479,657 | (4,001) | (277,392) | 205,945 | — | 205,945 |
| Balance at January 1, 2025 | 7,769 | 488,990 | (209) | (275,489) | 221,061 | — | 221,061 |
| Profit (loss) for the period | — | — | — | (14,719) | (14,719) | (169) | (14,888) |
| Reserves | — | — | — | — | — | — | — |
| Other comprehensive income (loss) for the period | — | — | 8,931 | — | 8,931 | — | 8,931 |
| Total comprehensive income (loss) for the period | — | — | 8,931 | (14,719) | (5,788) | (169) | (5,957) |
| Other reserves | — | — | (30) | 30 | — | — | — |
| Income tax benefit from excess tax deductions related to share-based payments | — | — | — | (225) | (225) | — | (225) |
| Share-based compensation | — | — | — | 2,576 | 2,576 | — | 2,576 |
| Options exercised / LTIP shares issued | 37 | 1,311 | — | (3,512) | (2,164) | — | (2,164) |
| Acquisition of a subsidiary | — | — | — | — | 5,869 | 5,869 | |
| Acquisition of non-controlling interests | — | — | (1,462) | (1,462) | (4,408) | (5,870) | |
| Total transactions with owners, recognized directly in equity | 37 | 1,311 | (30) | (2,593) | (1,275) | 1,461 | 186 |
| Balance at March 31, 2025 | 7,806 | 490,301 | 8,692 | (292,801) | 213,998 | 1,292 | 215,290 |
| CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS | ||
| For the period ended March 31 | ||
| Amounts in $’000 | 1Q 2025 | 1Q 2024 |
| Profit (loss) before tax | (11,788) | (16,624) |
| Adjustments to reconcile net profit (loss) to net cash used in operating activities: | ||
| Depreciation, amortization, impairment of non-current assets | 2,582 | 5,921 |
| Equity settled share based payments | 2,576 | 2,427 |
| Loss (gain) on disposal of leases | 4 | — |
| Other finance income | (604) | (1,779) |
| Other finance expenses | 5,028 | 1,556 |
| Share of net losses (profits) in associates using the equity method | 232 | 535 |
| Other | — | 783 |
| Operating cash flows before changes in working capital | (1,970) | (7,181) |
| Changes in working capital: | ||
| Inventories | (1,083) | 877 |
| Trade and other receivables | 5,385 | 7,461 |
| Payables and other current liabilities | (2,857) | (9,414) |
| Restricted cash | (26) | 28 |
| Total changes in working capital | 1,419 | (1,048) |
| Interest received | 737 | 582 |
| Income taxes received (paid) | 46 | — |
| Net cash flows generated from (used in) operating activities | 232 | (7,647) |
| Capital expenditure for property, plant and equipment | (282) | (80) |
| Investment intangible assets | (6) | — |
| Disposal of investment designated as at FVOCI | — | 1,971 |
| Investment in associates using the equity method | (411) | — |
| Purchases of marketable securities | — | (94,778) |
| Proceeds from sale of marketable securities | 67,866 | 93,551 |
| Acquisition of a subsidiary, net of cash acquired | (57,476) | — |
| Net cash flows generated from (used in) investing activities | 9,691 | 664 |
| Payment of lease liabilities | (715) | (1,034) |
| Interests on lease liabilities | (275) | (290) |
| Interests on convertible bonds | — | (2,031) |
| Settlement of share based compensation awards | 241 | 884 |
| Acquisition of non-controlling interests | (5,970) | — |
| Net cash flows generated from (used in) financing activities | (6,719) | (2,471) |
| Increase (decrease) of cash | 3,204 | (9,454) |
| Exchange rate effects | 1,945 | (395) |
| Cash and cash equivalents at January 1 | 54,944 | 61,741 |
| Total cash and cash equivalents at March 31 | 60,093 | 51,892 |
Attachment
FAQ
What were PHARM's Q1 2025 revenue and growth compared to Q1 2024?
How many patients are currently on paid Joenja therapy for PHARM in Q1 2025?
What is PHARM's updated revenue guidance for 2025?
How did PHARM's RUCONEST perform in Q1 2025?
What major management changes occurred at PHARM in Q1 2025?
