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Phio Pharmaceuticals Corp. reports developments as a clinical-stage siRNA biopharmaceutical company advancing its proprietary INTASYL® gene-silencing technology for immuno-oncology. Company updates center on PH-762, an INTASYL compound designed to silence the PD-1 gene and evaluated as an intratumoral therapy for cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma.
Recurring news themes include PH-762 clinical results, safety and pathology data, nonclinical toxicology work, cGMP clinical-supply manufacturing, regulatory-development steps, financial results, equity financing activity and investor presentations. Coverage also reflects the company's use of self-delivering RNAi technology intended to enhance immune-cell activity against tumor cells without specialized formulation or delivery systems.
Phio Pharmaceuticals (NASDAQ: PHIO) will present clinical results from its ongoing Phase 1b trial of intratumoral INTASYL PH-762 at the 40th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), November 7-9, 2025.
The poster (Abstract #610) titled "PD-1 Directed Intratumoral Immunotherapy for Cutaneous Carcinomas: A Clinical Study of INTASYL PH-762" will be presented by Mary Spellman, M.D. on Saturday, November 8, 2025 at the Prince George ABC Exhibit Halls, Gaylord National Resort and Convention Center.
The Phase 1b dose-escalation study evaluates safety and tolerability of intratumoral PH-762 in patients with cutaneous squamous carcinoma, Merkel cell carcinoma, and melanoma.
Phio Pharmaceuticals (NASDAQ: PHIO) announced on November 7, 2025 that its INTASYL compound PH-762 won the 2025 Immunomodulatory Solution of the Year award from the BioTech Breakthrough Awards program.
The company is a clinical-stage biopharmaceutical developer using its proprietary INTASYL siRNA gene‑silencing platform focused on cancer therapies. Company leadership highlighted PH-762 as an intratumoral immunotherapy intended to enhance cancer treatment efficacy, and the award organization noted PH-762 addresses a medical need for non‑surgical options for cutaneous carcinomas.
Phio Pharmaceuticals (NASDAQ: PHIO) announced definitive agreements to exercise outstanding warrants to purchase an aggregate of 5,663,182 shares of common stock at exercise prices between $2.00 and $5.45, producing expected gross proceeds of approximately $13.4 million before placement agent fees and offering expenses.
The offering closes in two tranches (first close on or about Nov 4, 2025, second close by Nov 18, 2025). Exercising holders will pay an additional $0.125 per new unregistered warrant ($1,415,795.50 aggregate) and receive new unregistered warrants to purchase up to 11,326,364 shares at a $2.05 exercise price, immediately exercisable with a 24‑month term following the resale registration effective date.
Phio intends to use net proceeds for working capital and to accelerate development activities for PH-762 in cutaneous carcinomas after recent positive safety and pathology results.
Phio Pharmaceuticals (NASDAQ: PHIO) reported pathologic results from the fifth and final dose cohort of its Phase 1b INTASYL PH-762 trial in cutaneous carcinomas on November 3, 2025. In the three patients completing the cohort, one had 100% tumor clearance, one had >90% clearance, and one had >50% clearance, with assessments at approximately 5 weeks after initial injection. To date, 18 patients have completed treatment across five cohorts, including 6 complete responses among 16 cSCC patients. The Safety Monitoring Committee reviewed safety at the maximum dose and found no dose-limiting toxicities; overall the trial reports no clinically relevant treatment-emergent adverse effects and dose escalation reached ~20-fold versus cohort 1. Trial identifier: NCT# 06014086.
Phio Pharmaceuticals (NASDAQ: PHIO) announced the appointment of David H. Deming as Lead Independent Director effective October 31, 2025.
Mr. Deming brings over 30 years of investment banking and asset management experience, including more than 27 years at JP Morgan and 12 years leading its Health Group. He joined Phio's board in February 2025 and currently serves on the board's Nominating Committee. The company said his background will support Phio's advancement of its INTASYL gene silencing technology in oncology.
Phio Pharmaceuticals (NASDAQ: PHIO) will present at the Renmark Financial Communications Live Virtual Non-Deal Roadshow on October 28, 2025 at 12:00 PM EST.
CEO and Chairman Robert Bitterman will provide an update on the company's proprietary INTASYL siRNA technology and progress in the ongoing Phase 1b dose-escalation trial of lead compound PH-762 for treatment of skin cancers. The company recently reported positive interim safety and efficacy results from that trial. A live Q&A will follow the presentation and a replay will be available on Renmark's website.
Phio Pharmaceuticals (NASDAQ: PHIO), a clinical-stage siRNA biopharmaceutical company, has announced its participation in the Renmark Financial Communications Virtual Non-Deal Roadshow Series. The presentation is scheduled for September 30, 2025, at 12:00 PM EST.
CEO and Chairman Robert Bitterman will discuss the company's proprietary INTASYL gene silencing technology and provide updates on their ongoing clinical trial of PH-762 for skin cancer treatment. The company recently reported positive interim safety and efficacy results from the Phase 1b dose escalation clinical trial.
Phio Pharmaceuticals (NASDAQ: PHIO), a clinical-stage biopharmaceutical company, will present at the Life Sciences Future Conference on September 26, 2025. CEO Robert Bitterman will provide updates on their ongoing Phase 1b clinical trial for skin cancer using their proprietary INTASYL® siRNA technology.
The presentation will focus on the company's PH-762 development program and discuss strategy and next steps following the treatment phase completion. Management will be available for one-on-one meetings during the conference on September 25-26 at the Sheraton Valley Forge Hotel in King of Prussia, PA.
Phio Pharmaceuticals (NASDAQ: PHIO), a clinical-stage biopharmaceutical company, will present at the H.C. Wainwright 27th Annual Global Investment Conference from September 8-10, 2025. CEO Robert Bitterman will provide updates on the company's ongoing Phase 1b clinical trial for skin cancer using their INTASYL® siRNA technology.
The presentation is scheduled for September 10, 2025, at 1:30-2 PM EST at the Lotte New York Plaza Hotel. Management will be available for one-on-one meetings throughout the conference, which investors can schedule through H.C. Wainwright representatives.
Phio Pharmaceuticals (NASDAQ: PHIO) reported Q2 2025 financial results and provided updates on its Phase 1b clinical trial for PH-762. The trial, evaluating intratumoral PH-762 in various skin cancers, has treated 15 patients across four cohorts with promising results. Among 13 cSCC patients, 5 achieved complete response, 1 near-complete response, and 1 partial response.
The company's cash position strengthened to $10.8 million as of June 30, 2025, up from $5.4 million in December 2024. Q2 2025 resulted in a net loss of $2.2 million, compared to $1.8 million in Q2 2024. In July 2025, Phio raised an additional $2.2 million through warrant exercises.