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Phio Pharmaceuticals Announces "How siRNA Therapy can Change the Course of Cancer Treatment" in a Fireside Chat with Force Family Office on Monday, June 29, 2026

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Phio Pharmaceuticals (NASDAQ: PHIO) will join a live virtual fireside chat hosted by Force Family Office on Monday, June 29, 2026 at 12 PM EDT. CEO Robert Bitterman and Dr. James Cardia will discuss siRNA therapy, skin cancer treatments, and Phio’s INTASYL® immuno-oncology program.

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News Market Reaction – PHIO

-5.90%
1 alert
-5.90% News Effect
-$743K Valuation Impact
$11.85M Market Cap
0.0x Rel. Volume

On the day this news was published, PHIO declined 5.90%, reflecting a notable negative market reaction. This price movement removed approximately $743K from the company's valuation, bringing the market cap to $11.85M at that time.

Data tracked by StockTitan Argus on the day of publication.

Market Context

The stock moved -5.9% in the session following this news. A negative reaction despite positive messa...
Analysis

The stock moved -5.9% in the session following this news. A negative reaction despite positive messaging fits PHIO’s pattern of weak trading after constructive updates. The company’s financing tools, including warrant-related resales and an ATM, and ongoing cash needs for PH-762 remain key overhangs for sentiment.

Key Figures

Fireside chat date: June 29, 2026 Fireside chat time: 12 PM EDT
2 metrics
Fireside chat date June 29, 2026 Scheduled virtual event with Force Family Office
Fireside chat time 12 PM EDT Start time for the June 29, 2026 virtual session

Historical Context

5 past events · Latest: Jun 24 (Positive)
Pattern 5 events
Date Event Sentiment 24h Move Catalyst
Jun 24 Pipeline milestone Positive -1.9% Commercial-scale cGMP production of PH-762 to support next clinical phase.
Jun 18 Investor conference Positive -2.3% Participation in Life Sciences Investor Forum to present INTASYL and PH-762.
May 26 Non-deal roadshow Positive -0.9% Virtual non-deal roadshow highlighting INTASYL platform and PH-762 trial.
May 12 Fireside chat Positive +1.9% Fireside chat discussing PH-762 Phase 1b data and operational runway.
May 07 Earnings & update Neutral -6.1% Q1 2026 financials and PH-762 development update with higher R&D spend.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Pattern Detected

PHIO often trades weakly after generally positive operational or outreach news, with more divergence than alignment in recent events.

Key Terms

sirna, gene silencing, immuno-oncology
3 terms
sirna medical
"Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA biopharmaceutical company"
Small interfering RNA (siRNA) is a short strand of genetic material that binds to and destroys the messenger RNA that carries instructions for making a specific protein, effectively switching that gene off. Investors care because siRNA is a platform for precise medicines: successful trials or approvals can create high-value drugs, while delivery challenges, manufacturing complexity, patent positions and regulatory risk can sharply affect a biotech company's prospects.
gene silencing medical
"using its proprietary INTASYL gene silencing technology to eliminate cancer"
Gene silencing is a biological process that turns down or shuts off the activity of a specific gene so it stops making its product, like dimming or muting a single light in a room instead of cutting power to the whole house. Investors care because therapies or products that intentionally silence harmful genes can become new drugs, diagnostics, or royalties, affecting a company’s future revenue, risk profile, and valuation.
immuno-oncology medical
"represents a differentiated and innovative approach to immuno-oncology"
Immuno-oncology is a field of medicine focused on using the body's immune system to fight cancer. It involves developing treatments that help the immune system recognize and attack cancer cells more effectively. For investors, advancements in immuno-oncology can signal promising new therapies that may lead to improved patient outcomes and potentially significant commercial opportunities.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Live virtual fireside chat - investors, advisors, and life sciences analysts invited to attend

King of Prussia, Pennsylvania--(Newsfile Corp. - June 25, 2026) - Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage siRNA biopharmaceutical company developing therapeutics using its proprietary INTASYL® gene silencing technology to eliminate cancer. Phio announced today that Mr. Robert Bitterman, CEO and Chairman of the Board, Phio Pharmaceuticals will participate in a fireside chat with Harvey Briggs, Chief Communications Officer, Force Family Office. Joining them will be James Cardia, Ph.D., who will explore siRNA therapy and skin cancer treatments.

"We are excited to take part in this fireside chat with Force Family Office," said Robert Bitterman, CEO and Chairman of Phio Pharmaceuticals. "Dr. Jim Cardia will discuss the future direction of siRNA oncology and highlight how our INTASYL® siRNA program represents a differentiated and innovative approach to immuno-oncology."

DATE: Monday June 29, 2026

TIME: 12 PM EDT

REGISTRATION LINK: PHIO Pharma - Force Family Office

About Phio Pharmaceuticals Corp.

Phio Pharmaceuticals Corp. (NASDAQ: PHIO) is a clinical-stage biopharmaceutical company advancing its proprietary INTASYL® siRNA gene silencing technology to eliminate cancer. Phio's INTASYL compounds are designed to enhance the body's immune cells to more effectively kill cancer cells. Phio's lead clinical development program is an INTASYL compound, PH-762, that silences the PD-1 gene implicated in various forms of skin cancer. The Phase 1b trial (NCT# 06014086) evaluated PH-762 for the treatment of cutaneous squamous cell carcinoma, melanoma and Merkel cell carcinoma. PH-762 is a potential non-surgical treatment for skin cancers.

For additional information, visit the Company's website, www.phiopharma.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as "intends," "believes," "anticipates," "indicates," "plans," "expects," "suggests," "may," "would," "should," "potential," "designed to," "will," "ongoing," "estimate," "forecast," "target," "predict," "could" and similar references, although not all forward-looking statements contain these words. These statements, which include statements, among other things, regarding the anticipated benefits of our INTASYL™ RNAi platform, the results from our ongoing clinical trials, our expectations that our cash runway will extend into the first half of 2027, our expectations regarding timing of FDA submissions intended to propose and seek guidance for next steps in clinical study design for PH-762, our expectations that such FDA submissions and any related FDA meetings will clarify next steps in advancing the PH-762 development program, details regarding our planned non-clinical toxicology study, and our ability to support ongoing clinical development, operational requirements and strategic initiatives with the capital we currently have on hand, are based only on our current beliefs, expectations and assumptions and are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements as a result of a number of important factors, including, but not limited to, the impact of future FDA interactions on the development of our product candidates; the impact to our business and operations by inflationary pressures; recession fears; the development of our product candidates, results from our nonclinical, preclinical and clinical activities, our ability to execute on business strategies, our ability to develop our product candidates with collaboration partners, and the success of any such collaborations, the timeline and duration for advancing our product candidates into clinical development, the timing or likelihood of regulatory filings and approvals, the success of our efforts to commercialize our product candidates if approved, our ability to manufacture and supply our product candidates for clinical activities, and for commercial use if approved, the scope of protection we are able to establish and maintain for intellectual property rights covering our technology platform, our ability to obtain future financing, market and other conditions and those risks identified in our most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q under the caption "Risk Factors" and in other filings the Company periodically makes with the U.S. Securities and Exchange Commission. Readers are urged to review these risk factors and to not act in reliance on any forward-looking statements, as actual results may differ from those contemplated by our forward-looking statements. Phio does not undertake to update forward-looking statements to reflect a change in its views, events or circumstances that occur after the date of this release, except as required by law.

Contact:
Phio Pharmaceuticals Corp.
Jennifer Phillips: jphillips@phiopharma.com
Corporate Affairs

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/302679

FAQ

What is Phio Pharmaceuticals (NASDAQ: PHIO) presenting on June 29, 2026?

Phio will participate in a live virtual fireside chat on June 29, 2026. According to Phio, leaders will discuss siRNA therapy, skin cancer treatments, and how the INTASYL® gene silencing platform may support future oncology approaches.

Who will represent Phio Pharmaceuticals (PHIO) in the Force Family Office fireside chat?

Phio will be represented by CEO and Chairman Robert Bitterman and James Cardia, Ph.D. According to Phio, they will join Harvey Briggs of Force Family Office to cover siRNA oncology, skin cancer therapies, and the INTASYL® program.

What topics will be discussed about siRNA therapy by Phio Pharmaceuticals on June 29, 2026?

The discussion will focus on siRNA therapy, skin cancer treatment, and oncology. According to Phio, Dr. Jim Cardia will outline the future direction of siRNA oncology and explain how the INTASYL® siRNA platform supports a differentiated immuno-oncology strategy.

When and at what time is the Phio Pharmaceuticals (PHIO) fireside chat with Force Family Office?

The virtual fireside chat is scheduled for Monday, June 29, 2026 at 12 PM EDT. According to Phio, investors, advisors, and life sciences analysts are invited to attend via an online registration link provided by the company.

How can investors attend the Phio Pharmaceuticals siRNA oncology fireside chat?

Investors can attend by registering through the event’s online registration link. According to Phio, the live virtual fireside chat with Force Family Office will be accessible to investors, advisors, and life sciences analysts interested in its INTASYL® siRNA oncology program.

What is Phio Pharmaceuticals’ INTASYL siRNA program mentioned for the June 29, 2026 event?

INTASYL® is described by Phio as its proprietary gene silencing siRNA technology. According to Phio, the June 29 discussion will highlight how this program may enable a differentiated and innovative approach to immuno-oncology and potential skin cancer treatments.