Welcome to our dedicated page for Pliant Therapeutics news (Ticker: PLRX), a resource for investors and traders seeking the latest updates and insights on Pliant Therapeutics stock.
Pliant Therapeutics, Inc. reports clinical and corporate developments for a clinical-stage biopharmaceutical company focused on integrin-based therapeutics. Its lead program, PLN-101095, is an oral small-molecule dual-selective inhibitor of αvβ8 and αvβ1 integrins being developed for solid tumors, including immune checkpoint inhibitor-refractory advanced or metastatic disease.
Company updates commonly cover Phase 1 and Phase 1b oncology data, scientific-conference presentations, combination studies with pembrolizumab, financial results, and healthcare investor-conference participation. Pliant also describes preclinical platform work using integrin receptor-binding molecules for tissue-specific delivery and internalization of drug payloads, including programs directed to skeletal muscle cells, adipocytes, and renal cells.
Pliant Therapeutics (Nasdaq: PLRX), a clinical-stage biotechnology firm, announced that its President and CEO, Bernard Coulie, will participate in two investor conferences in May 2022. The RBC Capital Markets Global Healthcare conference will feature a fireside chat on May 18 at 10:00 a.m. ET, while a replay of the H.C. Wainwright Global Investment Conference chat will be available on May 23 at 7:00 a.m. ET. Interested parties can access these events on Pliant's Investor Relations page.
Pliant Therapeutics (Nasdaq: PLRX) provided a corporate update on May 9, 2022, announcing a $100 million loan facility from Oxford Finance that extends its cash runway to mid-2024. The company is advancing its clinical programs, notably the INTEGRIS-IPF Phase 2a trial for PLN-74809, expected to yield data in mid-2022. The drug received FDA Fast Track and EMA Orphan Drug designations for treating idiopathic pulmonary fibrosis and primary sclerosing cholangitis. Financially, R&D and G&A expenses increased, resulting in a net loss of $28.1 million for Q1 2022.
Pliant Therapeutics, a clinical-stage biotechnology company, has secured a loan facility of up to $100 million from Oxford Finance LLC. This non-dilutive financing is aimed at advancing its lead clinical candidate, PLN-74809, for treating idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). The funding will extend Pliant's cash runway to mid-2024, supporting multiple upcoming clinical milestones. An initial draw of $10 million has been made, with further funds available based on performance milestones.
Pliant Therapeutics (NASDAQ: PLRX) announced that its drug candidate, PLN-74809, has received Fast Track designation from the FDA for treating idiopathic pulmonary fibrosis (IPF). This designation highlights the urgent need for new treatments for this severe disease, which affects approximately 140,000 people annually in the U.S. PLN-74809, currently in a Phase 2a clinical trial (INTEGRIS-IPF), aims to address the high unmet medical need as existing therapies do not halt disease progression. Topline data from the trial is expected in mid-2022.
Pliant Therapeutics (Nasdaq: PLRX) is presenting five posters at the ATS 2022 International Conference from May 13-18 in San Francisco. The posters showcase data supporting the development of PLN-74809, a dual-selective inhibitor for idiopathic pulmonary fibrosis (IPF). Key findings include dose-dependent target engagement and a favorable safety profile. Pliant is also featured in a special presentation during the ATS Respiratory Innovation Summit. PLN-74809 is currently in Phase 2 trials and has received Orphan Drug Designation from the FDA for IPF and primary sclerosing cholangitis.
Pliant Therapeutics (Nasdaq: PLRX), a clinical-stage biotechnology company, will have its CEO, Bernard Coulie, participate in a fireside chat at the 21st Annual Needham Virtual Healthcare Conference on April 12, 2022, at 2:15 p.m. ET. The event can be accessed via the Investor Relations’ Events & Presentation page on Pliant’s website, with an audio archive available for 30 days. Pliant focuses on developing therapies for fibrosis, with its lead candidate, PLN-74809, targeting idiopathic pulmonary fibrosis and primary sclerosing cholangitis, having received Orphan Drug Designation from the FDA.
Pliant Therapeutics, Inc. (Nasdaq: PLRX) recently corrected its financial reporting for 2021, highlighting significant advancements in its pipeline. The company reported a net loss of $24.5 million for Q4 2021, up from $19 million in the previous year. R&D expenses increased to $18.8 million, while G&A expenses rose to $7.8 million. PLN-74809, its lead therapeutic candidate, demonstrated robust biological activity in a Phase 1b trial and is poised for further trials in idiopathic pulmonary fibrosis and primary sclerosing cholangitis. The company has $200.6 million in cash, sufficient to fund operations into H2 2023.
Pliant Therapeutics (Nasdaq: PLRX) reported significant advancements in its pipeline in 2021, highlighted by promising Phase 1b trial results for PLN-74809, which demonstrated up to 92% inhibition of TGF-β activation in healthy subjects. The company is actively progressing into 2022 with a focus on idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC), including upcoming pivotal trials and regulatory developments. Financially, the company reported a net loss of $24.5 million in Q4 2021, an increase from the previous year, but maintains a robust cash position of $200.6 million to fund operations into mid-2023.
Pliant Therapeutics announced positive results from the expanded PLN-74809 Phase 1b trial, demonstrating significant TGF-β suppression in healthy participants, with reductions of up to 92% and 76% at 6 and 24 hours, respectively. The treatment was well tolerated, with no serious adverse events reported. This trial supports PLN-74809's potential as an antifibrotic therapy for idiopathic pulmonary fibrosis (IPF) and provides a favorable safety profile, contributing to de-risking ongoing Phase 2a trials.
Pliant Therapeutics (PLRX) announced the continuation of the INTEGRIS-IPF Phase 2a trial for PLN-74809, an oral treatment for idiopathic pulmonary fibrosis (IPF), without modifications following a positive recommendation from the Data Safety Monitoring Board (DSMB). The trial now progresses to evaluate a dosing increase to 320 mg daily over at least six months. PLN-74809 has demonstrated a favorable safety profile with over 450 participants showing no serious drug-related adverse events. Topline data is expected mid-2022.