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Pliant Therapeutics, Inc. reports clinical and corporate developments for a clinical-stage biopharmaceutical company focused on integrin-based therapeutics. Its lead program, PLN-101095, is an oral small-molecule dual-selective inhibitor of αvβ8 and αvβ1 integrins being developed for solid tumors, including immune checkpoint inhibitor-refractory advanced or metastatic disease.
Company updates commonly cover Phase 1 and Phase 1b oncology data, scientific-conference presentations, combination studies with pembrolizumab, financial results, and healthcare investor-conference participation. Pliant also describes preclinical platform work using integrin receptor-binding molecules for tissue-specific delivery and internalization of drug payloads, including programs directed to skeletal muscle cells, adipocytes, and renal cells.
Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical stage biotechnology firm focused on fibrosis treatments, announced that Dr. Bernard Coulie will attend two upcoming conferences in March 2022. The first is the Cowen 42nd Annual Health Care Conference on March 8 at 2:10 p.m. ET, where he will join a respiratory/infections panel. The second is the Oppenheimer 32nd Annual Healthcare Conference on March 16 at 3:20 p.m. ET, where he will present a company update. Presentations can be accessed via the investor relations page of Pliant’s website.
Pliant Therapeutics (PLRX) announced the completion of enrollment in its INTEGRIS-IPF Phase 2a clinical trial, evaluating PLN-74809 in patients with idiopathic pulmonary fibrosis (IPF). The FDA has authorized long-term treatment evaluation of PLN-74809 at doses up to 320 mg. Topline data from the trial is expected mid-2022. The company plans to provide updates at the 40th Annual J.P. Morgan Healthcare Conference on January 12, 2022. The trial involves 84 patients over a 12-week period, assessing safety and efficacy metrics.
Pliant Therapeutics, a clinical stage biotechnology firm focused on fibrosis treatments, announced that its CEO, Bernard Coulie, will present a company update at the 40th Annual J.P. Morgan Healthcare Conference.
The virtual presentation is scheduled for January 12, 2022, at 9:45 a.m. ET. Access is available via the Investor Relations' Events page on Pliant's website, with a replay option for 30 days post-event.
Pliant's lead candidate, PLN-74809, is in Phase 2a trials for idiopathic pulmonary fibrosis and primary sclerosing cholangitis.
Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical-stage biotechnology company, announced participation in virtual fireside chats at upcoming investor conferences. The Piper Sandler 33rd Annual Virtual Healthcare Conference will feature a pre-recorded chat on November 22, 2021, at 10:00am ET. The Evercore ISI 4th Annual HealthconX Conference will occur on November 30, 2021, at 3:30pm ET. Presentations can be accessed on Pliant's website, with audio available for 90 days post-event. Pliant is focused on developing therapies for fibrosis, including their lead candidate, PLN-74809.
Pliant Therapeutics (PLRX) released its third quarter 2021 financial results, showcasing productive progress in clinical trials. Positive interim data from the Phase 2a PET trial showed up to 98% αvβ6 target engagement in patients with idiopathic pulmonary fibrosis (IPF). Enrollment for ongoing trials INTEGRIS-IPF and INTEGRIS-PSC is on track, with topline data expected mid-2022. Research and development expenses rose to $21.1 million, contributing to a net loss of $27.0 million. The company maintains a robust cash position of $221.0 million, projected to sustain operations into 2023.
Pliant Therapeutics (Nasdaq: PLRX) announced that CEO Bernard Coulie will participate in a virtual fireside chat during Piper Sandler Lung Day on October 15, 2021, at 11:00 a.m. ET. This event will focus on the company's efforts in developing novel therapeutics for fibrosis, particularly its lead candidate, PLN-74809, which targets idiopathic pulmonary fibrosis and primary sclerosing cholangitis. A replay of the chat will be available on Pliant's website for 90 days post-event.
Pliant Therapeutics announced positive interim results from its Phase 2a trial of PLN-74809 in patients with idiopathic pulmonary fibrosis (IPF). The single-dose administration achieved up to 98% target engagement in the lungs, exceeding the predicted threshold for anti-fibrotic activity across all doses. The trial demonstrated a dose-dependent response and indicated that PLN-74809 targets fibrotic regions effectively. The ongoing trial aims to assess safety and pharmacokinetics, while the company anticipates future clinical outcomes based on these findings.
Pliant Therapeutics (Nasdaq: PLRX) plans to release interim clinical data from its Phase 2a PET imaging trial of PLN-74809 for idiopathic pulmonary fibrosis (IPF) on September 7, 2021. The company will host a conference call and webcast at 8:00 a.m. ET to discuss this update. PLN-74809 is an oral dual selective inhibitor of αvß6 and αvß1 integrins, currently in trials for IPF and primary sclerosing cholangitis (PSC), and has received Orphan Drug Designation for both indications.
Pliant Therapeutics, a clinical stage biotechnology company, announced its participation in two upcoming investor conferences. The Citi 16th Annual BioPharma Virtual Conference is set for September 8-9, 2021, where the management team will engage in one-on-one meetings. Following this, the Cantor 2021 Virtual Global Healthcare Conference will occur on September 29, 2021, featuring a presentation by CEO Bernard Coulie at 2:40 p.m. ET, along with additional one-on-one meetings. Pliant is focused on developing therapies for fibrosis, including its lead candidate for idiopathic pulmonary fibrosis and primary sclerosing cholangitis.
Pliant Therapeutics (Nasdaq: PLRX) provided an update showing progress in its Phase 1a trial for PLN-74809, with SAD cohorts up to 640 mg and MAD cohorts up to 320 mg completed without safety concerns. The Phase 2a trials for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC) are on track for enrollment completion by late 2021 and early 2022, respectively. Financially, the company reported a net loss of $22.8 million for Q2 2021, up from $17.0 million the previous year, driven by increased R&D expenses. Cash reserves stand at $244 million, expected to fund operations into 2023.