Promis Neuroscie Stock Price, News & Analysis

ProMIS Neurosciences (Nasdaq: PMN) reported positive topline data from its Phase 1a clinical trial of PMN310 for Alzheimer's disease, meeting objectives for tolerability, safety, and pharmacokinetics. The company secured up to $122.7 million in private placement financing to advance the Phase 1b study in the second half of 2024. Key highlights include:

1. PMN310 was well-tolerated with no serious adverse events in the first four cohorts.
2. The drug crossed into the central nervous system in quantities suggesting potential target engagement.
3. PMN310's selectivity could differentiate it in efficacy and safety profile.
4. The upcoming Phase 1b trial will enroll 100 patients and measure important clinical endpoints over 12 months.
5. Q2 2024 financials show cash and equivalents of $1.0 million, with R&D expenses at $1.6 million and a net loss of $2.6 million.

ProMIS Neurosciences (Nasdaq: PMN) announced the publication of two papers highlighting the role of toxic misfolded superoxide dismutase-1 (SOD1) aggregates in the pathogenesis of amyotrophic lateral sclerosis (ALS). The research, published in Acta Neuropathologica and Open Biology, supports targeting misfolded proteins as a therapeutic strategy for ALS.

Key findings include:

• SOD1 aggregates are present in both familial and sporadic ALS neural tissues
• A previously underappreciated SOD1 amyloidogenic region in β-strand II and III is important for aggregation and toxicity
• The existence of measurable SOD1 seeds across different forms of ALS contributes to the fundamental understanding of the disease

ProMIS is developing PMN267, an antibody targeting toxic misfolded TDP-43, as a potential ALS therapeutic. The research reinforces the company's broader strategy of targeting misfolded proteins in neurodegenerative diseases.

ProMIS Neurosciences Inc. (Nasdaq: PMN), a biotechnology company specializing in therapeutics for neurodegenerative diseases, has announced its participation in the BTIG Virtual Biotechnology Conference 2024. The company's representatives, Neil Warma (interim CEO) and Dr. Larry Altstiel (Chief Medical Officer), will engage in a fireside chat on August 6, 2024, at 12:00 p.m. ET.

ProMIS Neurosciences focuses on developing treatments targeting toxic misfolded proteins, which are associated with various neurodegenerative conditions. The fireside chat will be available via live webcast to conference attendees, providing an opportunity for investors and industry professionals to gain insights into the company's progress and future plans.

ProMIS Neurosciences Inc. (Nasdaq: PMN) presented preclinical data at the 2024 Alzheimer's Association International Conference (AAIC) supporting their novel approach to optimizing an Alzheimer's disease (AD) vaccine. The company's proprietary computational platform identified four AβO-restricted conformational B cell epitopes as vaccine candidates. Vaccination with these epitopes produced strong antibody responses without measurable pro-inflammatory T cell responses against Aβ. Notably, immunization with epitope 301, the target of PMN310, alone was sufficient to produce maximal reactivity against brain AβO.

The study suggests that ProMIS' approach could potentially lead to an AD vaccine capable of inducing an effective antibody response against pathogenic Aβ. This vaccine could be administered as a preventative measure to at-risk individuals or given therapeutically to diagnosed patients to inhibit AD progression.

ProMIS Neurosciences (Nasdaq: PMN) has reported positive top-line data from the first four cohorts of its Phase 1a clinical trial of PMN310 in healthy volunteers for Alzheimer's disease. The results showed:

• A favorable safety profile and tolerability across four ascending dose levels
• Dose-dependent levels of PMN310 antibody in cerebrospinal fluid (CSF)
• Potential for target engagement in Alzheimer's patients

PMN310 was well-tolerated with no serious adverse events observed. The antibody demonstrated dose proportionality in CSF and a half-life of approximately 25 days, supporting monthly dosing. ProMIS plans to advance PMN310 into a Phase 1b study in Alzheimer's patients in the second half of 2024.

ProMIS Neurosciences (Nasdaq: PMN) has announced a private placement financing of up to $122.7 million. The deal includes an upfront $30.3 million and potential additional $92.4 million from warrant exercises. The financing involves issuing Common Share Units and Pre-Funded Units at $2.15 and $2.14 per unit, respectively. Each unit includes various warrants with different exercise prices and expiration conditions.

The funds will support the development of PMN310, ProMIS' lead antibody therapeutic for Alzheimer's disease. The financing is expected to close on July 31, 2024, subject to conditions. Notable investors include Great Point Partners, Armistice Capital, and Ally Bridge Group. Guggenheim Securities led the placement, with Ceros Financial Services and Leede Financial as additional agents.

ProMIS Neurosciences (Nasdaq: PMN) reported its Q1 2024 financial results and corporate updates. The company is progressing with its Phase 1a clinical trial of PMN310 for Alzheimer's disease (AD), expecting top-line data by mid-2024. The trial evaluates safety, tolerability, and pharmacokinetics in healthy volunteers. ProMIS also plans a Phase 1b study in H2 2024. Recent publications support PMN310’s potential. In the ALS program, PMN267 showed promising preclinical data. ProMIS selected PMN400 as a lead vaccine candidate for synucleinopathies. Financially, ProMIS reported a cash decrease to $2.5M, R&D expenses of $2.1M, G&A expenses of $1.6M, and a net loss of $3.6M.

ProMIS Neurosciences Inc. published a study highlighting the selectivity of PMN310 in targeting toxic soluble aggregates in neurodegenerative diseases such as Alzheimer’s disease. The study shows PMN310's differentiation from other amyloid-beta-directed antibodies and its potential to improve efficacy and reduce risk associated with plaque-binding therapies. PMN310 is currently undergoing Phase 1a clinical studies, with promising initial data expected in mid-2024.