ProMIS Neurosciences Announces First Quarter 2026 Financial Results and Provides Corporate Highlights
Rhea-AI Summary
ProMIS Neurosciences (Nasdaq: PMN) reported Q1 2026 results and major funding and clinical milestones. The company closed a PIPE financing with potential gross proceeds up to $175 million, including warrant exercises, and held $63.8 million in cash, expected to fund operations through 2027.
The PRECISE-AD Phase 1b trial of PMN310 in Alzheimer’s disease is fully enrolled with 144 participants. A blinded 6‑month safety and biomarker interim analysis is planned for early Q3 2026, with 12‑month unblinded top‑line data anticipated in early 2027.
Positive
- PIPE financing with potential gross proceeds of up to $175 million
- Completed private placement for $75.5 million in upfront gross proceeds
- Cash and equivalents of $63.8 million as of March 31, 2026
- Cash runway expected to fund operations through 2027, including PRECISE-AD completion
- PRECISE-AD Phase 1b trial fully enrolled with 144 participants
- Unblinded 12‑month top‑line PMN310 data anticipated in early 2027
Negative
- Quarterly net loss of $8.2 million, up from $7.3 million year over year
News Market Reaction – PMN
In the May 12 session, PMN declined 1.78%, reflecting a mild negative market reaction.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Previous Earnings Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Mar 25 | Full-year 2025 earnings | Positive | -9.1% | Reported 2025 results, full PRECISE-AD enrollment and financing runway through 2027. |
| Nov 12 | Q3 2025 earnings | Positive | +4.0% | Q3 2025 update with >85% PRECISE-AD enrollment and strengthened cash position. |
| Aug 13 | Q2 2025 earnings | Positive | +0.0% | Fast Track for PMN310, growing trial enrollment and post-quarter $21.6M financing. |
| May 12 | Q1 2025 earnings | Neutral | -0.2% | Q1 2025 results with higher R&D spend and continued PRECISE-AD trial progress. |
| Mar 31 | Full-year 2024 earnings | Positive | -0.6% | 2024 results, initiation of 100-patient PRECISE-AD trial and PIPE financing details. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Earnings releases have historically produced modest moves, with a slight negative average and a mix of aligned and divergent reactions to generally positive operational updates.
Over recent earnings cycles, ProMIS has repeatedly highlighted advancement of its PRECISE-AD Phase 1b trial for PMN310, moving from initial enrollment in 2024 to completion of 144 patients and planning for interim and top-line readouts by early 2027. Financial updates have included growing R&D spend, evolving cash balances, and multiple financings, including a $75.5M upfront raise as part of up to $175M. Today’s Q1 2026 results continue that narrative, emphasizing completed enrollment, clear data timelines, and runway through 2027.
Key Terms
phase 1b medical
oligomers medical
alpha-synuclein medical
TDP-43 medical
PIPE financing financial
AI-generated analysis. How Rhea-AI works. Not financial advice.
- Company closed PIPE financing with gross proceeds of up to
$175 million , including the possible exercise of warrants, from long-term global investors. Proceeds are expected to fund the Company through 2027, including completion of the ongoing Phase 1b clinical trial in Alzheimer's disease (AD). - PRECISE-AD Phase 1b trial is fully enrolled and progressing on schedule, with the blinded 6-month interim analysis anticipated in early Q3 2026 and 12-month top-line data anticipated in early 2027.
- The planned interim analysis is expected to include a qualitative assessment of aggregated safety data, including amyloid-related imaging abnormalities (ARIA) incidence, as well as key biomarker trends across all study participants at the 6-month timepoint.
Cambridge, Massachusetts, May 12, 2026 (GLOBE NEWSWIRE) -- ProMIS Neurosciences Inc. (Nasdaq: PMN), a clinical-stage biotechnology company focused on the generation and development of antibody therapeutics targeting toxic misfolded proteins in neurodegenerative diseases, today announced its financial results for the quarter ended March 31, 2026, and provided a corporate update.
"2026 has the potential to be a significant year for patients with Alzheimer's disease and their caregivers,” said Neil Warma, Chief Executive Officer of ProMIS Neurosciences. “We believe ProMIS is well-positioned with PMN310 as a potentially differentiated treatment for patients with early AD. We are coming off a productive quarter, having closed a transformational financing of up to
With currently marketed AD therapies, safety remains a central concern. Both approved plaque-directed antibodies carry black box warnings for a serious side effect known as ARIA, which encompasses cerebral edema (ARIA-E) and microhemorrhages (ARIA-H) in the brain. ARIA is believed to be associated with therapies that bind amyloid plaque. Given the modest clinical benefit observed with these therapies, ARIA-related risk has been a meaningful consideration in real-world treatment decisions for many patients and physicians.
A growing body of evidence supports the view that toxic soluble amyloid-beta oligomers, small soluble species that form upstream of plaque, are a primary driver of cognitive decline in AD. PMN310 has been designed to selectively target these toxic oligomers while sparing plaque, a mechanism we believe may enable improved efficacy and a differentiated safety profile relative to plaque-directed antibodies.
ProMIS’s Phase 1b trial, PRECISE-AD, was fully enrolled in December 2025, exceeding the company’s target, and we are now approaching the 6-month timepoint of the trial. The upcoming blinded interim data analysis anticipated in early Q3 2026 will summarize aggregate safety data and overall trends in key biomarkers across all study participants, without revealing treatment assignments. Because the analysis pools active and placebo groups under the blind, even modest directional changes could provide early indications of target engagement while preserving the integrity of the trial.
ProMIS expects to complete 12-month dosing for all patients by year-end and to report unblinded top-line results in early 2027, providing a comprehensive view of PMN310's safety, biomarker, and clinical outcomes by treatment group, and an important clinical test of PMN310’s selective targeting approach."
Corporate Highlights
Alzheimer’s Disease (AD) Program (PMN310)
- The Company is conducting the PRECISE‑AD Phase 1b clinical trial, which is fully enrolled with 144 participants across three dosing cohorts receiving treatment over a 12‑month period.
- A blinded interim analysis is anticipated in early third quarter 2026, providing a mid‑study review of aggregated safety data and overall biomarker trends across all participants. As this analysis remains blinded, individual treatment assignments will not be disclosed, and results will represent combined data from both active and placebo groups. While this interim analysis is not designed to assess clinical efficacy, this early look may reveal directional biomarker trends that offer early insight into target engagement.
- Full patient dosing is expected to be completed by year‑end 2026, with unblinded top‑line results anticipated in early 2027. At that time, the Company expects to evaluate biomarker outcomes and clinical measures by treatment group, providing a comprehensive understanding of PMN310’s potential in Alzheimer’s disease.
Pipeline Progress and Scientific Presentations
- AD/PD™ 2026 Presentations: ProMIS featured two key presentations at the Alzheimer’s Disease/Parkinson’s Disease International Conference highlighting the versatility of its discovery platform:
-
- Dr. Neil Cashman, CSO, presented on the rational design of a vaccine against TDP-43 proteinopathies using a pathogenic epitope of misfolded TDP-43.
- Dr. Johanne Kaplan, CDO, presented data on how vaccination with conformational epitopes derived from computational modeling elicits an active antibody response selective for toxic alpha-synuclein species.
- Subcutaneous Formulation: The Company has accelerated the development of a subcutaneous formulation for PMN310 to enhance patient convenience and further strengthen the asset’s competitive profile.
Recent and Future Activities and Upcoming Milestones
- Closed Private Placement: Completed a private placement in February 2026 for gross up-front proceeds of
$75.5 million , with the potential to secure an additional$100 million upon exercise of warrants.
- Bloom Burton & Co. Healthcare Investor Conference: Neil Warma, CEO, participated and presented a corporate overview. View here: PMN Corporate Overview
- Fierce Biotech Week: Neil Warma, CEO, will participate in a panel discussion titled “Combination, Prevention, and New Biology in Neurodegenerative Drug Development”.
- Alzheimer’s Association International Conference (AAIC): Poster presentation titled “Activity and clinical progress of PMN310 designed to selectively target toxic Aß oligomers for greater potency in Alzheimer’s disease” will be presented by Johanne Kaplan, Chief Development Officer.
- Interim Data Readout: Blinded interim analysis of PRECISE-AD safety and biomarker data anticipated early Q3 2026.
- Top-line Results: Presentation of 12-month unblinded top-line data anticipated in early 2027.
Key Pipeline Programs
- Development of subcutaneous formulation for PMN310
-
- We have accelerated the development of a subcutaneous formulation of PMN310 and established a dedicated development plan, reflecting our conviction in the potential of this approach to improve patient experience and strengthen the asset's competitive profile.
- Amyotrophic Lateral Sclerosis Disease Program (PMN267)
-
- PMN267 is the lead preclinical candidate antibody directed against toxic misfolded TDP-43 as a potential therapeutic target for ALS and other TDP-43 proteinopathies (e.g. frontotemporal dementia). It has demonstrated strict selectivity for pathogenic TDP-43 and protective activity in antibody and intrabody formats. PMN267 has been humanized in a human IgG1 framework for IND-enabling studies.
- Parkinson’s Disease (PD), Dementia with Lewy Bodies and Multiple System Atrophy (MSA) Disease Program (PMN442)
-
- ProMIS selected PMN442 as the lead candidate antibody for PD and other synucleinopathies based on its selective binding and protective activity against pathogenic forms of alpha-synuclein. It has been humanized in a human IgG1 framework for IND-enabling studies.
First Quarter 2026 Financial Highlights
- Cash Position: As of March 31, 2026, the Company’s cash and cash equivalents were
$63.8 million , reflecting the$75.5 million in gross up-front proceeds from the February financing.
- Cash Runway: Based on the current operating plan, existing cash resources are expected to fund planned operations through 2027, including the completion of the PRECISE-AD trial.
- Net Loss: For the quarter ended March 31, 2026, the Company reported a net loss of
$8.2 million , compared to a net loss of$7.3 million for the same period in 2025.
About ProMIS Neurosciences Inc.
ProMIS Neurosciences is a clinical-stage biotechnology company committed to the discovery and development of therapeutic antibodies and vaccines selective for toxic oligomers associated with the development and progression of neurodegenerative and other misfolded protein diseases. The Company’s proprietary target discovery engine, EpiSelect™, has been shown to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins that cause neurodegenerative and other misfolded protein diseases, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), multiple system atrophy (MSA), and Parkinson’s Disease (PD). ProMIS has offices in Cambridge, Massachusetts (USA) and Toronto, Ontario (CAN).
About PMN310 and the PRECISE-AD Trial for Alzheimer’s Disease (AD)
PMN310, the Company’s lead product candidate for the treatment of AD, is a humanized IgG1 monoclonal antibody that has been designed to selectively target only the toxic oligomers, avoiding plaque, thereby potentially reducing, or eliminating amyloid-related imaging abnormalities (ARIA) liability. In addition, because PMN310 may not be limited by off-target binding or side effects, PMN310 could potentially offer an improved efficacy profile over other amyloid-directed antibody therapeutics. PMN310 was granted Fast Track designation by the U.S. Food and Drug Administration in July 2025.
Based on the encouraging results from the Phase 1a trial (NCT06105528) of PMN310 in healthy volunteers, ProMIS initiated PRECISE-AD, a Phase 1b clinical trial in AD patients. PRECISE-AD (NCT06750432) is a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability and pharmacokinetics (PK) of multiple ascending doses (5, 10, 20 mg/kg) of intravenous PMN310 in patients with Mild Cognitive Impairment due to AD or mild AD (Stage 3 and Stage 4 AD). PRECISE-AD will be the first study to examine the effects of a monoclonal antibody directed solely against Aβ oligomers on biomarkers associated with AD pathology and clinical outcomes. Safety will be a primary outcome of the study with particular emphasis on assessing whether, as a non-plaque binder, PMN310 may have a reduced risk of ARIA. The study is powered to provide
EpiSelectTM Drug Discovery Engine
Toxic misfolded proteins underlie the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Generation of therapeutic antibodies selectively targeting only disease-misfolded protein isoforms, while sparing normal or irrelevant isoforms of the same protein, has not yet been successfully achieved by conventional immunization strategies. ProMIS Neurosciences has developed a computational platform (EpiSelect™) to identify conformational epitopes that are uniquely exposed on toxic misfolded proteins, which can then be used to generate misfolding-specific antibodies or vaccine formulations. Application of the ProMIS platform produced PMN310, a clinical stage, humanized monoclonal antibody candidate that has been shown to be highly selective for toxic amyloid-beta oligomers (AβO) without significant reactivity with amyloid-beta monomers or fibrils, thereby avoiding target distraction by these more abundant species, and potentially reducing the risk of brain edema and microhemorrhages associated with the targeting of vascular/parenchymal amyloid. Similarly, specific epitopes for alpha-synuclein toxic oligomers/soluble fibrils that drive synucleinopathies, and for pathogenic TDP-43 in ALS and FTD have been identified and lead candidate antibodies generated. The precise conformation of these epitopes has been translated into vaccines inducing an antibody response selective for pathogenic molecular species in preclinical mouse vaccination studies.
Forward-looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Certain information in this news release constitutes forward-looking statements and forward-looking information (collectively, “forward-looking information”) within the meaning of applicable securities laws. In some cases, but not necessarily in all cases, forward-looking information can be identified by the use of forward-looking terminology such as “plans”, “pleased to”, “look forward to”, “potential to”, “targets”, “expects” or “does not expect”, “is expected”, “excited about”, “an opportunity exists”, “is positioned”, “estimates”, “intends”, “assumes”, “expects”, “anticipates” or “does not anticipate” or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might”, “will” or “will be taken”, “occur” or “be achieved”. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances contain forward-looking information. Specifically, this news release contains forward-looking information relating to the Company’s Phase 1b study in AD patients, including planned timing for completion and anticipated data read out of interim results in the third quarter of 2026 and topline results by early 2027, statements relating to the Company's progress, including enrollment and dosing for its Phase 1b clinical trial, the potential for PMN310 to positively benefit patients with AD, the targeting of toxic misfolded proteins in neurodegenerative diseases that the Company believes may directly address fundamental AD pathology (including the belief and understanding that toxic oligomers of Aß are a major driver of AD) and have greater therapeutic potential due to reduction of off-target activity, and the ability of the Company’s cash runway to fund operations through 2027. Statements containing forward-looking information are not historical facts but instead represent management’s current expectations, estimates and projections regarding the future of our business, future plans, strategies, projections, anticipated events and trends, the economy and other future conditions. Forward-looking information is necessarily based on a number of opinions, assumptions and estimates that, while considered reasonable by the Company as of the date of this news release, are subject to known and unknown risks, uncertainties and assumptions and other factors that may cause the actual results, level of activity, performance or achievements to be materially different from those expressed or implied by such forward-looking information, including, but not limited to, including, but not limited to, the risk that preclinical results or early results may not be indicative of future results, its accumulated deficit and the expectation for continued losses and future financial results. Important factors that could cause actual results to differ materially from those indicated in the forward-looking information include, among others, the factors discussed throughout the “Risk Factors” section of the Copany’s most recently filed Annual Report on form-10-K for the year ended December 31, 2025 and in its subsequent filings filed with the United States Securities and Exchange Commission. Except as required by applicable securities laws, the Company undertakes no obligation to publicly update any forward-looking information, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.
Condensed Consolidated Balance Sheets (Unaudited)
| March 31, | December 31, | ||||||
| 2026 | 2025 | ||||||
| Assets | |||||||
| Current assets: | |||||||
| Cash | $ | 63,814,345 | $ | 6,116,556 | |||
| Short-term investments | 33,753 | 33,753 | |||||
| Prepaid expenses and other current assets | 1,764,594 | 3,032,112 | |||||
| Total current assets | 65,612,692 | 9,182,421 | |||||
| Prepaid expenses, long-term | 1,798,879 | — | |||||
| Total assets | $ | 67,411,571 | $ | 9,182,421 | |||
| Liabilities and Shareholders' Equity | |||||||
| Current liabilities: | |||||||
| Accounts payable | $ | 1,716,823 | $ | 2,543,415 | |||
| Accrued liabilities | 4,897,796 | 7,868,416 | |||||
| Total current liabilities | 6,614,619 | 10,411,831 | |||||
| Share-based compensation liability | 79,380 | 29,182 | |||||
| Total liabilities | 6,693,999 | 10,441,013 | |||||
| Shareholders' equity: | |||||||
| Common Shares, no par value, unlimited shares authorized, 8,967,693 and 2,152,397 shares issued and outstanding as of March 31, 2026 and December 31, 2025, respectively | — | — | |||||
| Additional paid-in capital | 199,739,348 | 129,518,812 | |||||
| Accumulated other comprehensive loss | (371,184) | (371,184) | |||||
| Accumulated deficit | (138,650,592) | (130,406,220) | |||||
| Total shareholders' equity | 60,717,572 | (1,258,592) | |||||
| Total liabilities and shareholders' equity | $ | 67,411,571 | $ | 9,182,421 | |||
Condensed Consolidated Statement of Operations (Unaudited)
| For the | For the | ||||||
| Three Months Ended | Three Months Ended | ||||||
| March 31, | March 31, | ||||||
| 2026 | 2025 | ||||||
| Operating expenses: | |||||||
| Research and development | $ | 6,971,005 | $ | 5,464,250 | |||
| General and administrative | 1,673,890 | 1,995,845 | |||||
| Total operating expenses | 8,644,895 | 7,460,095 | |||||
| Loss from operations | (8,644,895) | (7,460,095) | |||||
| Other income | 400,523 | 112,192 | |||||
| Net loss | $ | (8,244,372) | $ | (7,347,903) | |||
| Net loss per share, basic and diluted | $ | (1.26) | $ | (5.27) | |||
| Weighted-average outstanding Common Shares, basic and diluted | 6,527,779 | 1,394,048 | |||||
For Investor Relations, please contact:
Carie Pierce VP, Investor Relations & External Affairs
IR@promisneurosciences.com
