ProMIS Neurosciences to Host Webinar to Discuss Upcoming 6-Month Blinded Interim Data from PRECISE-AD Phase 1b Trial of PMN310 in Alzheimer’s Disease
Rhea-AI Summary
ProMIS Neurosciences (Nasdaq: PMN) will host a webinar on July 28, 2026, 8:00–9:00 am ET to review upcoming six-month blinded interim data from the PRECISE-AD Phase 1b trial of its lead Alzheimer’s candidate PMN310. Company executives and KOLs Dr. Will Mantyh and Dr. Michael Weiner will discuss aggregate safety findings and trends in select biomarkers in patients with early Alzheimer’s disease.
PRECISE-AD is a randomized, double-blind, placebo-controlled study of multiple ascending intravenous doses (5, 10, 20 mg/kg) of PMN310 over twelve months in 144 enrolled participants. PMN310, a selective anti-amyloid-beta oligomer antibody, received FDA Fast Track designation in July 2025.
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News Market Reaction – PMN
In the Jul 28 session, PMN gained 23.89%, reflecting a significant positive market reaction. Argus tracked a peak move of +46.8% during that session. Argus tracked a trough of -2.6% from its starting point during tracking. Our momentum scanner triggered 40 alerts that day, indicating elevated trading interest and price volatility. Trading volume was exceptionally heavy at 15.8x the daily average, suggesting very strong buying interest.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Jul 14 | PMN310 clinical update | Positive | +6.7% | Reported human target engagement and dose-dependent amyloid-beta oligomer reduction |
| May 28 | Conference participation | Positive | +3.8% | Outlined upcoming healthcare conferences and PRECISE-AD data timelines |
| May 12 | Q1 earnings report | Positive | -1.8% | Reported financing proceeds, cash runway, and completed PRECISE-AD enrollment |
| Apr 13 | Investor conference | Positive | +2.5% | Announced conference presentation and highlighted PRECISE-AD development progress |
| Mar 25 | FY2025 earnings report | Positive | -9.1% | Reported enrollment completion, safety update, and financing runway through 2027 |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
PMN310-specific and conference-related updates were followed by positive reactions, while both recent earnings announcements were followed by declines.
Key Terms
pharmacokinetics medical
monoclonal antibody medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
Cambridge, Massachusetts, July 27, 2026 (GLOBE NEWSWIRE) -- ProMIS Neurosciences Inc. (Nasdaq: PMN), a clinical-stage biotechnology company developing antibody therapeutics and vaccines targeting toxic misfolded proteins in neurodegenerative diseases, today announced that it will host a webinar on Tuesday, July 28, 2026, at 8:00 am ET, featuring Key Opinion Leaders (KOLs) Dr. Will Mantyh, Associate Professor with Tenure, University of Minnesota Medical School and Dr. Michael Weiner, Professor Emeritus, University of California, San Francisco. They will join company leadership to discuss the Company's six-month blinded interim data from the PRECISE-AD Phase 1b trial evaluating PMN310 in patients with early Alzheimer's disease (AD). The analysis will focus on blinded aggregate safety data and overall trends in select biomarkers across study participants.
Webinar Details
Date: July 28, 2026
Time: 8:00-9:00 am ET
Speakers (ProMIS): Neil Warma, Chief Executive Officer, and Dr. Larry Altstiel, Chief Medical Officer
KOLs: Dr. Will Mantyh and Dr. Michael Weiner
Registration link: https://lifescievents.com/event/it38tlq/
About Dr. Will Mantyh
William G. Mantyh, M.D. is an Associate Professor with Tenure in Behavioral/Cognitive Neurology at the University of Minnesota, specializing in Alzheimer's disease and related neurodegenerative disorders. His research focuses on blood-based biomarkers, APOE genetics, and expanding equitable access to Alzheimer's diagnosis and treatment in underserved communities. He is the principal investigator of a
About Dr. Michael Weiner
Dr. Weiner is UCSF Professor Emeritus of Radiology and Biomedical Imaging, Medicine, Psychiatry, and Neurology, and the CEO of the AI voice company, Vaicro. He has conducted research for over 60 years and is Principal Investigator of the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the BrainHealthRegistry.org. He was one of the first to perform nuclear magnetic resonance on an intact animal. He then pursued development of MRI/MRS as a clinical tool and established the Center for Imaging of Neurodegenerative Diseases at the San Francisco VAMC. Dr. Weiner has published over 1,030 peer-reviewed articles, trained dozens of postdoctoral fellows, and received numerous honors including the Alzheimer’s Association’s Nancy and Ronald Reagan Award, the Potamkin Prize of the American Academy of Neurology, a Docteur Honoris Causa Degree from Paul Sabatier University, Toulouse, France, and the Henry Wisniewski Lifetime Achievement Award in Alzheimer's Disease Research, from the Alzheimer's Association in 2021. His current interest is AI applications to ADRD research, especially development of AI-powered conversational voice agents to perform clinical and cognitive assessments.
About PMN310 and the PRECISE-AD Trial for Alzheimer’s Disease (AD)
PMN310, ProMIS’ lead product candidate for the treatment of AD, is a humanized IgG1 monoclonal antibody designed to selectively target only the toxic oligomers of amyloid-beta (AβOs), believed to be among the earliest and most damaging drivers of Alzheimer's disease, while avoiding binding to amyloid plaques and vascular deposits. This selectivity may reduce or eliminate the risk of amyloid-related imaging abnormalities (ARIA), including brain swelling (ARIA-E) and microhemorrhages (ARIA-H), which are commonly associated with plaque-binding antibodies. PMN310 was granted Fast Track Designation by the U.S. Food and Drug Administration in July 2025.
Based on encouraging results from a Phase 1a trial (NCT06105528) in healthy volunteers, ProMIS initiated the PRECISE-AD Phase 1b trial to evaluate PMN310 in patients with mild cognitive impairment due to AD or mild AD. PRECISE-AD (NCT06750432) is a randomized, double-blind, placebo-controlled study evaluating the safety, tolerability, and pharmacokinetics of multiple ascending doses (5, 10, and 20 mg/kg) of intravenous PMN310. The study has completed enrollment of 144 participants across the three dosing cohorts who are being treated for twelve months. It is designed to provide meaningful insight into the effects of PMN310 on biomarkers and clinical outcomes.
About ProMIS Neurosciences Inc.
ProMIS Neurosciences is a clinical-stage biotechnology company committed to the discovery and development of therapeutic antibodies and vaccines selective for toxic oligomers associated with the development and progression of neurodegenerative and other misfolded protein diseases. The Company’s proprietary target discovery engine, EpiSelect™, has been shown to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins that cause neurodegenerative diseases, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), multiple system atrophy (MSA), and Parkinson’s disease (PD). ProMIS has offices in Cambridge, Massachusetts (USA).
For further information:
Visit us at www.promisneurosciences.com
Media Contact
Maggie Whitney
LifeSci Communications
mwhitney@lifescicomms.com
Investor Relations Contact
Carie Pierce
VP Investor Relations & External Affairs
IR@ProMISNeurosciences.com
