Welcome to our dedicated page for Purple Biotech news (Ticker: PPBT), a resource for investors and traders seeking the latest updates and insights on Purple Biotech stock.
Purple Biotech Ltd. (PPBT) generates frequent news as a clinical-stage oncology company developing therapies that, according to its own reports, target tumor immune evasion and drug resistance. Investors and observers following PPBT news can track updates on its CAPTN-3 tri-specific antibody platform, the CEACAM1-blocking antibody CM24, and the dual IRS1/2 and STAT3 inhibitor NT219, as well as financing and listing developments.
Recent press releases highlight CAPTN-3 as a key source of news. The company has announced manufacturing milestones for IM1240, the first tri-specific antibody from the platform targeting 5T4, CD3 and NKG2A, including achievement of a commercially viable yield. Additional updates describe non-human primate toxicology data for IM1240, with Purple Biotech reporting an expanded therapeutic window compared with a non-capped comparator and a pharmacokinetic profile characterized by increased systemic exposure and prolonged half-life in that study.
News flow also covers preclinical data presentations at scientific meetings such as the ESMO Immuno-Oncology Congress and other conferences. These releases describe anti-tumor activity of IM1240 and IM1305 in models resistant to prior PD-1 therapy, transcriptomic analyses supporting the inclusion of an NKG2A arm, and ex vivo results in patient-derived tumor biopsies. Such items provide context on how the company positions CAPTN-3 within immuno-oncology research.
Beyond CAPTN-3, Purple Biotech issues updates on CM24 Phase 2 data in pancreatic ductal adenocarcinoma and on NT219, including an intention to grant a European patent for NT219 combination regimens and progress of a Phase 2 study in recurrent and/or metastatic squamous cell carcinoma of the head and neck. Financial and corporate news includes quarterly results, public offerings of American Depositary Shares and warrants, at-the-market offering agreements, and Nasdaq minimum bid price notifications.
Readers who monitor PPBT news can use this page to follow scientific milestones, regulatory and clinical progress, capital-raising transactions, and listing-related announcements directly sourced from company press releases and SEC-furnished documents.
Purple Biotech (NASDAQ/TASE: PPBT) announced the appointment of Gil Efron as Chief Executive Officer, effective July 10, 2022. This follows the transition of Isaac Israel to an advisory role while remaining a board member. Efron, previously the President and CFO, emphasized the company’s commitment to developing innovative cancer therapies, including its leading assets NT219 and CM24. The leadership change aims to drive growth as the company progresses through key clinical trials.
Purple Biotech (NASDAQ/TASE: PPBT) announced positive interim data from its Phase 1 study of NT219 for advanced solid tumors. The results showed a confirmed partial response in a patient with gastroesophageal junction cancer treated for 22 weeks, with stable disease observed in 75% of patients with mutated-KRAS colon cancer. The company is advancing plans to study NT219 in combination with cetuximab for metastatic cancers. As of May 12, 2022, 14 patients were enrolled, with no Grade 4 adverse events reported.
Purple Biotech (NASDAQ/TASE: PPBT) announced the initiation of the Phase 2 study for CM24, a monoclonal antibody targeting pancreatic cancer. This decision follows positive interim Phase 1b data, showing confirmed response rates and a favorable safety profile. The study will prioritize pancreatic ductal adenocarcinoma (PDAC) in collaboration with Bristol Myers Squibb, allowing for an increased number of participants and an accelerated timeline to complete the trial by 2023. This advancement is expected to extend Purple Biotech's cash runway through 2024.
Purple Biotech, listed as PPBT, reported Q1 2022 financial results, highlighting a net loss of $7.3 million, or $0.41 per ADS, compared to a loss of $6.6 million, or $0.38 per ADS, in Q1 2021. Research and Development expenses increased by 22% to $6.0 million, primarily due to CMC costs. However, Sales, General, and Administrative expenses decreased to $1.4 million. The company had $42.2 million in cash and equivalents at the end of Q1. Clinical advancements include completing enrollment for NT219 and initiating expansion arms for CM24.
Purple Biotech (NASDAQ/TASE: PPBT) has reported promising safety and efficacy results for CM24, a first-in-class monoclonal antibody, in combination with Opdivo® (nivolumab) for treating advanced solid tumors, including pancreatic cancer (PDAC). In a Phase 1b study presented at the AACR 2022 Annual Meeting, none of the 11 patients experienced dose-limiting toxicities. The treatment yielded one confirmed partial response and three stable disease results, indicating a 36% disease control rate. Pharmacokinetics showed dose-proportional exposure, paving the way for further clinical development.
Purple Biotech Ltd. (NASDAQ/TASE: PPBT) reported its financial results for 2021, highlighting significant advancements in its oncology pipeline. The company is currently conducting Phase 1/2 trials for NT219 and CM24, with encouraging preliminary data. Financially, Purple Biotech experienced a net loss of $18.5 million, or $1.05 per share, a decrease from a net loss of $28 million in 2020. Cash reserves totaled $47.4 million, providing a runway into 2024. However, the discontinuation of Consensi, due to low revenue prospects, impacted 2021 results, reporting a loss of $0.6 million from discontinued operations.
Purple Biotech (NASDAQ: PPBT) reported a successful 2021, laying a foundation for future growth in cancer therapies. CEO Isaac Israel highlighted advancements in their clinical pipeline, especially with lead assets CM24 and NT219, which are poised for significant data readouts in 2022. The company maintains a robust financial position with $47.5 million in cash reserves. Collaborations with Bristol Myers-Squibb and The University of Texas MD Anderson Cancer Center enhance their development strategy. Overall, 2022 is projected to be a pivotal year for Purple Biotech as they continue progressing in oncology.
Purple Biotech announced the appointment of Ori Hershkovitz to its Board of Directors, aiming to leverage his extensive experience in life sciences investment. Hershkovitz has a successful history in managing substantial healthcare assets, and he expressed enthusiasm for the company’s oncology pipeline, which includes NT219 and CM24. These therapies are designed to target tumor immune evasion and drug resistance, promising potential benefits for cancer patients. The leadership change is expected to enhance corporate growth initiatives and shareholder value.
Purple Biotech announced the appointment of Fabien Sebille, Ph.D., as its Chief Business Officer. Dr. Sebille, with over 15 years in the biotechnology sector and a proven track record in oncology licensing deals, will lead the company’s business development. His experience includes senior roles at Debiopharm and co-founding TcLand Expression. The appointment aims to enhance strategic partnerships and advance Purple Biotech’s oncology pipeline, notably CM24 and NT219. The company is in a strong financial position and focused on driving long-term shareholder value.
Purple Biotech (NASDAQ/TASE: PPBT) announced the initiation of Part 2 of its Phase 1/2 clinical trial for NT219, a dual inhibitor targeting IRS1/2 and STAT3, in combination with cetuximab for treating recurrent or metastatic squamous cell carcinoma of the head and neck or colorectal adenocarcinoma. Part 1 has progressed well, with good safety and promising efficacy signals. Initial data support expanding the study, with further efficacy results expected in mid-2022, and potential new indications anticipated in the latter half of 2022.