Welcome to our dedicated page for Purple Biotech news (Ticker: PPBT), a resource for investors and traders seeking the latest updates and insights on Purple Biotech stock.
Purple Biotech Ltd (PPBT) is a clinical-stage oncology innovator developing therapies to combat tumor resistance mechanisms. This hub provides investors and researchers with timely updates on the company’s pipeline progress, including its dual inhibitor NT219, CEACAM1-targeting CM24 antibody, and tri-specific antibody platform.
Key resources include: Press releases detailing clinical trial milestones for lead candidates, partnership announcements with pharmaceutical collaborators, and regulatory filings related to drug development. Users will find analysis of preclinical data alongside updates on combination therapy strategies involving immunotherapies.
Bookmark this page to efficiently track PPBT’s advancements in overcoming immune evasion through novel mechanisms like STAT3 inhibition and localized immune activation. Check regularly for new insights into trial designs, biomarker analyses, and strategic initiatives shaping the future of precision oncology.
Purple Biotech (NASDAQ/TASE: PPBT) announced promising initial results from a Phase 1/2 clinical trial of NT219 for advanced solid tumors. As of April 25, 2021, six patients were enrolled, with NT219 demonstrating a favorable safety profile and minimal adverse events. Notably, a patient with refractory gastroesophageal junction cancer achieved a partial response after 22 weeks. This dual inhibitor targets IRS1/2 and STAT3, potentially overcoming drug resistance. The company expects to release further data from higher doses in the latter half of 2021.
Purple Biotech Ltd. (NASDAQ/TASE: PPBT), a clinical-stage company focused on developing innovative therapies to combat tumor immune evasion and drug resistance, announced its participation in the Jefferies Virtual Healthcare Conference. Management will present on June 4, 2021, at 8:30am EST. The conference occurs from June 1-4, 2021, and allows for one-on-one meetings. Purple Biotech's pipeline includes NT219 and CM24, aimed at treating various cancers. Interested parties can access the live and replay webinars on their official website.
Purple Biotech Ltd. (NASDAQ/TASE: PPBT) announced it will present interim data from its ongoing Phase 1/2 clinical trial of NT219 on June 4, 2021, at the ASCO Annual Meeting. NT219 is a dual inhibitor targeting IRS1/2 and STAT3, being evaluated as a monotherapy and in combination with cetuximab for advanced solid tumors, including head and neck cancer. The company anticipates further top-line data in the second half of 2021, showcasing its commitment to developing therapies that address tumor immune evasion and drug resistance.
Purple Biotech has appointed Suzana Nahum-Zilberberg to its Board of Directors, enhancing its leadership team. Nahum-Zilberberg, a seasoned biopharmaceutical executive, aims to leverage her operational expertise to advance the company's anti-cancer product candidates, NT219 and CM24. Dr. Eric Rowinsky, the Board Chairman, expressed excitement about her addition, highlighting the importance of her background in driving the company's mission to develop impactful therapeutics. Purple Biotech's pipeline includes innovative therapies targeting tumor immune evasion and drug resistance, with ongoing clinical studies and partnerships with major firms.
Purple Biotech (Nasdaq/TASE: PPBT) announced the first patient has been dosed in a Phase 1b/2 clinical trial of CM24, a monoclonal antibody targeting CEACAM1, in combination with nivolumab for advanced cancer patients. The trial focuses on non-small cell lung cancer (NSCLC) and pancreatic cancer. Preliminary data is expected in the second half of 2021. The trial will assess safety, pharmacokinetics, and efficacy, with multiple sites planned across the U.S., E.U., and Israel. This collaboration with Bristol Myers Squibb marks a significant step in the development of CM24.
Purple Biotech announced additional preclinical data for NT219, a dual inhibitor targeting IRS1/2 and STAT3, presented at the AACR 2021 Meeting. The study analyzed over 16,000 CRC samples, revealing IRS2 amplification in brain metastases. In vitro results showed that NT219 reduced viability in IRS2-expressing cells. The combination of NT219 with 5-FU significantly inhibited brain metastasis formation in an animal model. The ongoing Phase 1/2 trial for NT219 will continue as planned, with top-line data expected in H2 2021.
Purple Biotech Ltd. (NASDAQ/TASE: PPBT) has initiated a Phase 1b/2 clinical trial for its monoclonal antibody CM24, aimed at treating advanced cancer patients. This trial, conducted in collaboration with Bristol Myers Squibb, will focus on non-small cell lung cancer (NSCLC) and pancreatic cancer. Preliminary results are expected in the second half of 2021. CM24 demonstrated a 33% disease control rate in previous studies, showing promise in targeting CEACAM1, a key immune checkpoint protein.
Purple Biotech, trading under the ticker PPBT on NASDAQ/TASE, has announced the presentation of new preclinical data on NT219, a dual inhibitor targeting IRS1/2 and STAT3. This data will be showcased at the AACR 2021 Annual Meeting from April 10-15 and May 17-21. The study highlights the significant role of IRS2 in colorectal cancer brain metastasis and suggests NT219’s potential in addressing this issue. Ongoing trials for NT219 as a treatment for solid tumors aim to deliver top-line data by late 2021.
Purple Biotech Ltd. (NASDAQ/TASE: PPBT) appointed Robert Gagnon to its Board of Directors, bringing 15 years of corporate finance expertise, primarily in biotech. Gagnon will serve until the 2022 annual general meeting. His appointment aims to leverage his experience as the company approaches key clinical milestones for anti-cancer therapies CM24 and NT219. Gagnon, currently Chief Business and Financial Officer at Verastem Oncology, has held significant financial roles at several biotech firms. This leadership change may enhance strategic direction and drive shareholder value.
Purple Biotech (PPBT) announced significant advancements in its anti-cancer therapies and financial results for 2020. Key highlights include the completion of patient recruitment for the NT219 clinical trial and imminent Phase 1b/2 studies for CM24. The company raised $68.5 million in 2020, ending with $60.8 million in cash, sufficient to support operations until 2024. Despite increased R&D expenses leading to a higher operating loss of $12.6 million, cash resources appear robust, supporting ongoing clinical initiatives aimed at improving cancer treatment outcomes.
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