Propanc Biopharma Provides Corporate Update & Year-End June 30, 2025-26, Financial Results
The planned trial still needs regulatory and ethics steps, while the reported tumor and survival results come from animal models.
Sentiment and the balance of points
Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.
Rhea-AI Summary
Propanc Biopharma (PPCB) reported a narrower annual loss and outlined plans for a Phase 1b study of PRP. The study is planned to start in the first quarter of 2027, with a first patient visit scheduled for April. It would enroll up to 50 patients with advanced solid tumors in Australia. In animal models of pancreatic cancer, PRP produced greater than 90% mean tumor growth inhibition versus controls and extended median survival by more than 2.5-fold.
For the year ended June 30, 2026, net loss narrowed to $18,862,710 from $58,923,300; revenue remained at zero. Annual gross proceeds raised totaled $7.5 million, including a public offering of 1,000,000 shares at $4.00 each. Cash stood at $832,006 at June 30, and a further $2.0 million was received from the Series C facility afterward. Total liabilities fell to $3,378,251 from $5,725,616. Propanc also authorized up to $5.0 million in share repurchases and completed a $500,000 first tranche.
How this balance works
Rhea-AI gives every point it takes from this document a weight. Minor counts 1, Moderate 3 and Major 9, so one Major point outweighs several Minor ones. The bar adds up the weights on each side, and when neither side holds more than 65% of the total the balance reads Mixed.
It reads the document as published, with the same rules for every company, and it does not look at what the market expected or at how the stock traded, so a point can be objectively good on a day the stock falls.
Rhea-AI Sentiment measures something else, the tone of the wording.
Hollow bars mark forward-looking points. How the balance works
Positive
- Major pointNet loss narrowed to $18,862,710 from $58,923,300 for the year ended June 30, 2026, but remained a loss.
- Major pointAnnual gross proceeds raised totaled $7.5 million in the 2025–26 financial year. 2.2× market cap
- Major pointSeries C funding brought in a further $2.0 million after June 30, 2026. 59% of market cap
- Moderate pointCash rose to $832,006 at June 30, 2026, from $12,088 a year earlier.
- Moderate pointTotal liabilities fell to $3,378,251 from $5,725,616 at June 30, 2025.
- Moderate point. Forward-looking: it has not happened yet and may not happen.PRP Phase 1b study is planned to start in the first quarter of 2027, with up to 50 patients.
- Moderate pointShare repurchases totaled $500,000 in the first tranche of a program authorizing up to $5.0 million. 15% of market cap
7 minor points
- Minor pointLoss per share narrowed to $17.62 from $371.22 for the year ended June 30, 2026.
- Minor pointConvertible notes fell to zero at June 30, 2026, from $537,921 a year earlier.
- Minor pointOperating expenses fell to $18,185,569 from $57,278,131 year over year.
- Minor pointPRP animal-model results showed greater than 90% mean tumor growth inhibition versus controls.
- Minor pointMedian survival was more than 2.5-fold longer in PRP-treated animals than controls.
- Minor pointFinished-product manufacturing is underway, and raw drug substance supply for the PRP formulation is secured.
- Minor point. Forward-looking: it has not happened yet and may not happen.FyoniBio service agreement covers development and validation of an assay for the planned PRP study.
Negative
- Major point1,000,000 common shares issued at $4.00 each in the public offering dilute existing holders.
- Moderate point. Forward-looking: it has not happened yet and may not happen.Series C convertible preferred stock issued under the private placement can dilute common holders.
- Moderate pointTotal assets fell to $12,779,912 at June 30, 2026, from $19,631,808 a year earlier.
- Moderate pointResearch and development expenses rose to $625,477 from $223,721 year over year.
- Moderate point. Forward-looking: it has not happened yet and may not happen.Clinical trial authorization approval is still targeted for February 2027, ahead of the scheduled first patient visit.
3 minor points
- Minor pointRevenue remained at zero for the year ended June 30, 2026.
- Minor pointDeemed dividend of $932,246 increased the 2026 net loss available to common stockholders.
- Minor pointAvance memorandum records the parties' intent to collaborate on clinical delivery, rather than a completed commitment.
News Explained
The facility's $100 million ceiling is not all cash received: Propanc reports $1 million initially, $3 million by June 30, and $2 million afterward.
Propanc places the planned PRP Phase 1b study in preparation, not patient testing: finished-drug manufacture is underway, PK method validation has commenced, and HREC submission materials are being prepared.
The company reports a private-placement agreement for up to
A private placement is a securities sale to selected investors outside a public offering; the release identifies Series C convertible preferred shares but gives no conversion mechanics, so any resulting effect on common ownership is not established here.
The timeline places CTA submission in
At
Sources and calculations
- Propanc Biopharma corporate update and year-end financial results (2026-09-29)
- Private placement / PIPE definition (undated)
- Propanc Biopharma quarterly fundamentals (2026Q4)
- Available liquidity against the last reported quarterly operating outflow, in days at that rate $832,006 / ($1,601,982 / 91) = 47.3 days
Details
Market Reaction – PPCB
On Sep 29, the day this news came out, the latest delayed price for PPCB is 2.10% below the previous close. Our momentum scanner has recorded 6 alerts for this stock so far that day. The latest delayed price is $0.52.
Data tracked by StockTitan Argus (15 min delayed). Upgrade to Gold for real-time data.
Key Figures
- Gross proceeds raised
- $7.5 million
- 2025-26 financial year
- Private placement agreement
- Up to $100 million
- Agreement entered into to support clinical development
- Net loss
- $18,862,710
- Year ended June 30, 2026
- Quarter-end cash
- $832,006
- June 30, 2026
- Planned study enrollment
- Up to 50 patients
- Phase 1b first-in-human study in advanced solid tumors
- Mean tumor growth inhibition
- Greater than 90%
- PRP in advanced PDAC models versus vehicle controls
- P-value
- p < 0.001
- Tumor growth inhibition in advanced PDAC models
- Median overall survival extension
- More than 2.5-fold
- Treated animals compared with controls
Historical Context
-
Reported >90% tumor-growth inhibition and >2.5-fold median survival extension in PRP models.
-
Reported >90% tumor-growth inhibition and >2.5-fold median survival extension in PRP models.
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Key Terms
pharmacokinetics medical
pharmacodynamics medical
gmp technical
hrec regulatory
lc-ms technical
AI-generated analysis. How Rhea-AI works. Not financial advice.
Plans To Commence World-First Phase 1b First-In-Human (FIH) Study of PRP Q1, 2027
MELBOURNE, Australia, Sept. 29, 2026 (GLOBE NEWSWIRE) -- Propanc Biopharma, Inc. (Nasdaq: PPCB) (“Propanc” or the “Company”), a biopharmaceutical company focused on developing novel treatments for chronic diseases, including recurrent and metastatic cancer, today announced an update on corporate progress and reported year-end financial results as of June 30, 2026 (Year end June 30).
CORPORATE HIGHLIGHTS
To commence a world-first Phase 1b FIH study of PRP in Q1, 2027
The multicenter, open-label study will enroll up to 50 patients with advanced solid tumors, including pancreatic, ovarian, and refractory prostate cancers, at trial centers across Australia. The two-part design, dose escalation (Part A) followed by dose expansion (Part B), is intended to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of PRP.
Several workstreams are advancing in parallel to support study start:
- Manufacturing: GMP manufacture of finished drug product is underway. A small-scale technology transfer run has been completed. Two scale-up runs are scheduled this month, with an engineering run planned for late October. Raw drug substance supply for the PRP formulation is secured after recent audit and vendor qualification processes were successfully completed.
- Bio-analytics: PK method validation has commenced. Development of an anti-drug antibody assay is underway, and in-use stability testing of the finished PRP formulation is scheduled.
- Regulatory and ethics: Supporting documentation for Human Research Ethics Committee (HREC) submission is in preparation, including the Investigator’s Brochure (IB), a briefing document drawn from the IB, and the clinical trial protocol. Documents will be provided to investigators at Australian trial sites for feasibility assessment ahead of the planned HREC submission in November 2026.
PRP will be administered as a weekly intravenous infusion on Days 1, 8, 15, and 22 of each 28-day cycle. Treatment may continue until a withdrawal criterion is met.
Compelling new preclinical and early translational data for its lead candidate PRP in pancreatic ductal adenocarcinoma (PDAC)
In orthotopic and patient-derived xenograft (PDX) models of advanced PDAC, three-times-weekly intravenous PRP achieved:
- Greater than
90% , mean, tumor growth inhibition versus vehicle controls (p < 0.001). - Marked reduction in metastatic burden in the liver and peritoneum.
- Significant remodeling of the tumor microenvironment, including decreased cancer-associated fibroblast activity, reduced fibrosis, and suppression of epithelial-mesenchymal transition (EMT) markers.
- Enhanced sensitivity of chemo-resistant PDAC cells to standard-of-care gemcitabine/nab-paclitaxel, supporting lower chemotherapy doses with improved efficacy.
- Median overall survival extension of more than 2.5-fold in treated animals compared with controls.
Results were built on previously reported >
Memorandum of Understanding (MOU) with Avance Clinical Pty Ltd
The MOU sets out the shared intent of Propanc and Avance to work together to support the clinical delivery of Propanc’s Phase 1b, FIH clinical study for PRP. Importantly, both parties intend to approach the collaboration in a spirit of openness, scientific rigor, and shared problem-solving with the goal of advancing PRP efficiently from FIH into Proof-of-Concept and, as data supports, later-phase development. Avance Clinical is a full-service Contract Research Organization (CRO) headquartered in Australia, with extensive operations across North America, Asia Pacific, New Zealand and Europe. With more than 30 years of experience leading early phase clinical trials, they leverage the unique advantages of the Australian market, including rapid ethics approval, and up to
Contract and Development Manufacturing Organization (CDMO) for GMP manufacture of PRP
The Spanish based CDMO provides end-to-end services for preclinical and clinical projects, with extensive experience in biologics production (plasmid DNA and recombinant proteins) providing services of cell line generation, banking and characterization, analytical development, process development and batches production of both drug substances and drug products. Management are pleased to undertake this pivotal step for GMP production of PRP for the upcoming Phase 1 FIH clinical study.
Service Agreement with FyoniBio GmbH to Establish & Validate Pharmacokinetics Assay for Phase 1b FIH Study
Management has executed a service agreement with FyoniBio GmbH (formerly Glycotope, est. 2010), a German Contract Development Organization (CDO) based in Berlin for establishing and validating a liquid chromatography-mass spectrometry (LC-MS) based pharmacokinetics (PK) assay. The objective is to quantify the Company’s lead asset, PRP, consisting of two proenzymes trypsinogen and chymotrypsinogen, as well as their activated enzyme forms trypsin and chymotrypsin from human serum during the Phase 1b FIH study.
Multi-Yr, Anti-Aging & Cancer Research Collaboration with the Universities of Jaén & Granada, Spain
A multi-year Joint Research Collaboration Agreement has been established with the Universities of Jaén (UJA) and Granada (UGR), Spain. The collaboration involves the evaluation of a senescence-modulating (i.e., anti-aging) compound to mitigate senescence and to complete experiments to further support the claims of recently filed fibrosis and cancer related patent applications, requested by Propanc to UJA’s research group “Biological Technologies of The University of Jaén” and UGR’s Research Group, “Advanced Therapies: Differentiation, Regeneration and Cancer.”
FINANCIAL HIGHLIGHTS
Proceeds raised
In the 2025-26 financial year totaled
Closed an underwritten public offering
1,000,000 shares at
Entered into a private placement agreement for up to
Received an initial
Commenced a share repurchase program authorizing the Company to repurchase up to
The Company completed the first tranche of
Year-end Financial Summary (Quarter Ended June 30, 2026)
- Total assets:
$12.78 million - Total liabilities reduced by
$2.20 million - Convertible notes reduced to
$0 (from$538,000) - Net cash from financing activities:
$6.46 million - Quarter-end cash:
$832,006 - A further
$2.0 million from the Series C facility received (post June 30)
The Company expects the financing facility to continually support planned R&D activities, including advancement of PRP and Rec-PRP.
Management Commentary
“The Propanc Executive team are delighted with advancements made in the past financial year,” said Mr. James Nathanielsz, Propanc’s Chief Executive Officer. “The Company is poised to capitalize on the foundation set in the next financial year with the advancement of PRP to a Phase 1b FIH study in up to 50 advanced cancer patients with solid tumors such as pancreatic, ovarian and refractory prostate cancers. Recent clinical advancements observed by companies such as Revolution Medicines and Erasca through KRAS inhibitors for pancreatic cancer are groundbreaking and tremendously exciting, but there is more work to be done to eliminate recurrence and metastasis in patients suffering from this killer disease. PRP is a potential breakthrough therapy that modulates the tumor micro-environment by targeting the EMT (epithelial-mesenchymal transition) process, which drives metastasis, invasion and recurrence from CSCs (cancer stem cells) which often lie dormant, post treatment, causing the cancer to return and spread. By eliminating this threat, not only can PRP improve survival, but is also non-toxic to healthy cells, meaning that patients could have a better quality of life, as well as enhance more durable response rates in combination with other treatments such as chemotherapy, checkpoint inhibitors, or KRAS inhibitors. We look forward to executing our scientific and clinical research activities in the 2026-2027 financial year.”
About Propanc Biopharma, Inc.
Propanc Biopharma, Inc. (Nasdaq: PPCB) is developing a novel approach to preventing cancer recurrence and metastasis by targeting and eradicating cancer stem cells through proenzyme activation. The Company’s lead product candidate, PRP, is designed to address the underlying drivers of cancer proliferation and spread.
More information: www.propanc.com
Forward-Looking Statements
All statements in this press release that are not historical are forward-looking statements, including, among other things, statements relating to the Company’s expectations regarding its market position and market opportunity, expectations and plans as to its product development, manufacturing and sales, and relations with its partners and investors, made in reliance upon the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements are not historical facts but rather are based on the Company’s current expectations, estimates, and projections regarding its business, operations and other similar or related factors. Words such as “may,” “will,” “could,” “would,” “should,” “anticipate,” “predict,” “potential,” “continue,” “expect,” “intend,” “plan,” “project,” “believe,” “estimate,” and other similar or related expressions are used to identify these forward-looking statements, although not all forward-looking statements contain these words. You should not place undue reliance on forward-looking statements because they involve known and unknown risks, uncertainties, and assumptions that are difficult or impossible to predict and, in some cases, beyond the Company’s control. Forward-looking statements are not guarantees of future actions or performance. Actual results may differ materially from those in the forward-looking statements because of several factors, including, without limitation, risks and uncertainties related to market conditions, as well as those risks described under “Risk Factors” in the prospectus related to the proposed offering and those described in the Company’s filings with the SEC. The Company undertakes no obligation to revise or update information in this release to reflect events or circumstances in the future, even if new information becomes available.
Company:
Propanc Biopharma, Inc.
James Nathanielsz
+61-3-9882-0780
info@propanc.com
Investor Contact:
| Clinical Research Activity for PRP | Timeline | |
| CTA | April 2025 – September 2026 | |
| Phase Ib Clinical Study Protocol | ||
| Investigator’s Brochure | ||
| CTA Compilation | October 2026 – November 2026 | |
| CTA Submission | November 2026 | |
| CTA Approval | February 2027 | |
| CTA Review | January 2027 – February 2027 | |
| Contract Research Organization and Contracts | February 2027 – March 2027 | |
| Analytical Laboratory Selection and Contracts | ||
| Trial Site Selection and Contracts | ||
| Preparation of Logistics | February 2027 – March 2027 | |
| Trial Site Initiation Visits | ||
| First Patient/First Visit | April 2027 | |
| PROPANC BIOPHARMA, INC. AND SUBSIDIARY | ||||||||
| CONSOLIDATED BALANCE SHEETS | ||||||||
| June 30, 2026 | June 30, 2025 | |||||||
| ASSETS | ||||||||
| CURRENT ASSETS: | ||||||||
| Cash | $ | 832,006 | $ | 12,088 | ||||
| GST tax receivable | 13,694 | 5,302 | ||||||
| Prepaid expenses - current portion | 7,661,967 | 8,334,046 | ||||||
| Other current assets | 34,923 | 1,380 | ||||||
| TOTAL CURRENT ASSETS | 8,542,590 | 8,352,816 | ||||||
| Deferred offering costs | - | 291,773 | ||||||
| Prepaid expenses - long-term portion | 4,190,543 | 10,925,835 | ||||||
| Security deposit - related party | 2,074 | 1,971 | ||||||
| Operating lease right-of-use assets, net - related party | 40,790 | 59,413 | ||||||
| Property and equipment, net | 3,915 | - | ||||||
| TOTAL ASSETS | $ | 12,779,912 | $ | 19,631,808 | ||||
| LIABILITIES AND STOCKHOLDERS’ EQUITY | ||||||||
| CURRENT LIABILITIES: | ||||||||
| Accounts payable | $ | 1,131,429 | $ | 1,249,596 | ||||
| Accrued expenses and other payables | 855,350 | 1,486,550 | ||||||
| Accrued interest | 128,318 | 190,795 | ||||||
| Loans payable | - | 65,280 | ||||||
| Loans payable - related parties, net of discount | 460,809 | 415,329 | ||||||
| Notes payable, net of discount | - | 543,312 | ||||||
| Convertible notes, net of discounts and including put premiums | - | 537,921 | ||||||
| Operating lease liability - related party, current portion | 24,489 | 17,664 | ||||||
| Embedded conversion option liabilities | - | 403,892 | ||||||
| Employee benefit liability | 754,038 | 667,901 | ||||||
| TOTAL CURRENT LIABILITIES | 3,354,433 | 5,578,240 | ||||||
| NON-CURRENT LIABILITIES: | ||||||||
| Loan payable - long-term - related party, net of discount | - | 105,627 | ||||||
| Operating lease liability - long-term portion - related party | 23,818 | 41,749 | ||||||
| TOTAL NON-CURRENT LIABILITIES | 23,818 | 147,376 | ||||||
| TOTAL LIABILITIES | $ | 3,378,251 | $ | 5,725,616 | ||||
| Commitments and Contingencies (See Note 9) | ||||||||
| STOCKHOLDERS’ EQUITY: | ||||||||
| Preferred stock, 1,500,005 shares authorized, | ||||||||
| Series A preferred stock, | $ | - | $ | - | ||||
| Series B preferred stock, | - | - | ||||||
| Series C preferred stock, | 2 | - | ||||||
| Common stock, | 3,310 | 464 | ||||||
| Common stock issuable (487,939 and 310 shares as of June 30, 2026 and 2025, respectively) | 487 | - | ||||||
| Additional paid-in capital | 152,752,314 | 138,254,808 | ||||||
| Accumulated other comprehensive income | 1,176,255 | 1,318,917 | ||||||
| Accumulated deficit | (144,484,230 | ) | (125,621,520 | ) | ||||
| Treasury stock ( | (46,477 | ) | (46,477 | ) | ||||
| TOTAL STOCKHOLDERS’ EQUITY | 9,401,661 | 13,906,192 | ||||||
| TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY | $ | 12,779,912 | $ | 19,631,808 | ||||
| PROPANC BIOPHARMA, INC. AND SUBSIDIARY | ||||||||
| CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) | ||||||||
| For the years ended June 30, | ||||||||
| 2026 | 2025 | |||||||
| REVENUE | ||||||||
| Revenue | $ | - | $ | - | ||||
| OPERATING EXPENSES | ||||||||
| Administration expenses | 670,607 | 108,950 | ||||||
| Compensation and related taxes | 2,275,937 | 23,296,390 | ||||||
| Professional and consulting expenses | 14,572,616 | 33,622,510 | ||||||
| Occupancy expenses - related party | 40,932 | 26,560 | ||||||
| Research and development | 625,477 | 223,721 | ||||||
| TOTAL OPERATING EXPENSES | 18,185,569 | 57,278,131 | ||||||
| LOSS FROM OPERATIONS | (18,185,569 | ) | (57,278,131 | ) | ||||
| OTHER INCOME (EXPENSE) | ||||||||
| Interest expense | (430,539 | ) | (563,757 | ) | ||||
| Interest income | 161 | 9 | ||||||
| Derivative expense | - | (333,596 | ) | |||||
| Change in fair value of derivative liabilities | 13,709 | 212,450 | ||||||
| Change in fair value of warrant liability | (99,695 | ) | - | |||||
| Other expense | (6,000 | ) | - | |||||
| Settlement expense | (320,000 | ) | - | |||||
| Gain (loss) on extinguishment of debt, net | 133,071 | (871,032 | ) | |||||
| Foreign currency transaction gain (loss) | 32,152 | (89,243 | ) | |||||
| TOTAL OTHER INCOME (EXPENSE), NET | (677,141 | ) | (1,645,169 | ) | ||||
| LOSS BEFORE TAXES | (18,862,710 | ) | (58,923,300 | ) | ||||
| Tax benefit | - | - | ||||||
| NET LOSS | $ | (18,862,710 | ) | $ | (58,923,300 | ) | ||
| Deemed Dividend | (932,246 | ) | - | |||||
| NET LOSS AVAILABLE TO COMMON STOCKHOLDERS | $ | (19,794,956 | ) | $ | (58,923,300 | ) | ||
| BASIC AND DILUTED NET LOSS PER SHARE | $ | (17.62 | ) | $ | (371.22 | ) | ||
| BASIC AND DILUTED WEIGHTED AVERAGE SHARES OUTSTANDING | 1,123,709 | 158,727 | ||||||
| NET LOSS AVAILABLE TO COMMON STOCKHOLDERS | $ | (19,794,956 | ) | $ | (58,923,300 | ) | ||
| OTHER COMPREHENSIVE INCOME (LOSS) | ||||||||
| Unrealized foreign currency translation gain (loss) | (142,662 | ) | 49,336 | |||||
| TOTAL OTHER COMPREHENSIVE INCOME (LOSS) | (142,662 | ) | 49,336 | |||||
| TOTAL COMPREHENSIVE LOSS | $ | (19,937,618 | ) | $ | (58,873,964 | ) | ||
FAQ
AI-generated questions and answers. How Rhea-AI works. Not financial advice.
What were Propanc Biopharma's financial results for the year ended June 30, 2026?
Propanc recorded a $18,862,710 net loss, compared with $58,923,300 a year earlier, and reported no revenue in either year. Basic and diluted loss per share was $17.62, compared with $371.22.
When is Propanc Biopharma's PRP Phase 1b trial expected to begin?
Propanc plans to start the study in the first quarter of 2027, while its trial schedule places the first patient visit in April 2027. The proposed Australian study would enroll up to 50 patients with advanced solid tumors.
What approvals remain before Propanc Biopharma's PRP trial can enroll its first patient?
Human Research Ethics Committee submission documents are being prepared for a planned November 2026 submission. Propanc's schedule also targets clinical trial authorization submission in November 2026 and approval in February 2027, before the first patient visit scheduled for April.