Plus Therapeutics Provides Updates on ReSPECT™ Clinical Trials at the 27th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
11/19/2022 - 08:24 AM
ReSPECT-GBM clinical trial of rhenium ( 186 Re) obisbemeda in recurrent glioblastoma continues to demonstrate safety and overall survival correlates with radiation dose to tumor
ReSPECT-GBM Phase 2 trial enrollment has begun
Update on ReSPECT-LM clinical trial and first-in-child Phase 1/2a pediatric brain cancer trial for ependymoma and high-grade glioma
AUSTIN, Texas, Nov. 19, 2022 (GLOBE NEWSWIRE) -- Plus Therapeutics, Inc. PSTV 186 Re) obisbemeda, in recurrent glioblastoma (GBM), leptomeningeal metastases (LM), as well as clinical trial plans for pediatric brain cancer at the 27th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology (SNO).
“Targeted radiotherapy using rhenium (186 Re) obisbemeda in patients with GBM and LM has, thus far, been shown to be both feasible and safe across a range of dosages and a variety of delivery parameters. Furthermore, it is unusual to see such a tight correlation between overall survival and absorbed dose at this point of clinical development,” said Andrew J. Brenner, M.D., Ph.D., Professor of Medicine, Neurology, and Neurosurgery at The University of Texas Health Science Center at San Antonio and principal investigator of the ReSPECT-GBM and ReSPECT-LM clinical trials. “This data strongly supports continued clinical development for several very difficult to treat CNS indications.”
The oral presentation titled, Report of the ReSPECT-GBM Phase 1/2a Dose Escalation Trial of Rhenium-186 NanoLiposome ( 186 RNL) in Recurrent Glioma via Convection Enhanced Delivery (CED) & Planned Phase 2b Trial [RADT-20], included the following key findings:
In 24 patients with recurrent glioblastoma, a single dose of rhenium (186 Re) obisbemeda was administered in the dose escalation phase, (range: 1.0 mCi/0.66 mL to 31.2 mCi/12.3 mL), achieving up to 740 Gray (Gy) of absorbed radiation dose to the tumor. Between one to four intracranial CED catheters have been placed in each patient and there have been no dose limiting toxicities and a good safety profile has been observed. A statistically significant improvement in overall survival correlated with both the average absorbed dose of radiation to the tumor and the percent volume of tumor treated, specifically: A 100 Gy increase in the absorbed dose correlated with a 35.7% decrease in the risk of death (p=0.003, Cox methods hazard ratios = 0.643) A 1% increase in tumor volume treated is associated with a 4.5% decrease in the risk of death (p=0.002, Cox methods hazard ratios = 0.955) A recommended Phase 2 dose of 22.3 mCi in 8.8 mL is being studied for tumor volumes of 20 mL or less and is expected to enroll up to an additional 31 patients. Continued dose escalation will be performed to assess the potential to treat tumors larger than 20 mL. The Company’s second oral presentation titled, Preclinical Data and Initial Clinical Experience in the Phase 1/2a Dose Escalation Trial of Rhenium-186 Nanoliposome ( 186 RNL) in Leptomeningeal Metastases [LM]: the ReSPECT-LM Trial [CTNI-02], highlighted data from the first two cohorts which demonstrates the potential of rhenium (186 Re) obisbemeda to treat LM:
As single rhenium (186 Re) obisbemeda dose administered through an intraventricular catheter (Ommaya reservoir) at 6.6 mCi in 5.0 mL in Cohort 1 achieved absorbed doses of 18.7 to 29.0 Gy to the ventricles and cranial subarachnoid space, which was well tolerated with no treatment-related adverse events of greater than grade 1. All four patients treated to date in Cohorts 1 and 2 were observed to have prompt and complete rhenium (186 Re) obisbemeda distribution throughout the cerebrospinal fluid (CSF) subarachnoid space that was durable to 28 days. All patients showed a decreased CSF tumor cell count by microfluidic chamber assay after treatment, ranging from 46% to 92% . In November 2022, Plus Therapeutics, in collaboration with Lurie Children’s Hospital investigators, anticipates filing an Investigational New Drug (IND) application for a first-in-child Phase 1/2a clinical trial to determine the maximum tolerated dose, safety, tolerability and early efficacy of rhenium (186 Re) obisbemeda in supratentorial recurrent or progressive pediatric ependymoma and high-grade glioma (HGG) in up to 24 patients initially. These plans were presented in a poster titled, A two-part, Phase 1 study of Rhenium-186 NanoLiposome ( 186 RNL) delivered by convection enhanced delivery (CED) for recurrent or progressive childhood ependymoma and high-grade glioma (HGG) [CTNI-19].
“Ependymoma and HGG are difficult-to-treat pediatric brain tumors that are frequently aggressive, and in recurrent settings, can carry extremely poor prognoses for these children,” said Norman LaFrance, M.D., Chief Medical Officer and Senior Vice President at Plus Therapeutics. “The standard of care for pediatric brain cancer is insufficient given the current limitations surrounding traditional external beam radiation therapy. However, we believe rhenium (186 Re) obisbemeda has potential to overcome these obstacles and more effectively manage this devastating disease, given our initial data seen in adults with recurrent glioblastoma. We look forward to working with the FDA to advance the pediatric study.”
Copies of the presentations will be available under the Presentations https://ir.plustherapeutics.com
About Plus Therapeutics
Plus Therapeutics, Inc. is a clinical-stage pharmaceutical company focused on the development, manufacture, and commercialization of complex and innovative treatments for patients battling cancer and other life-threatening diseases. Our proprietary nanotechnology platform is currently centered around the enhanced delivery of a variety of drugs using novel liposomal encapsulation technology. Liposomal encapsulation has been extensively explored and undergone significant technical and commercial advances since it was first developed. Our platform is designed to facilitate new delivery approaches and/or formulations of safe and effective, injectable drugs, potentially enhancing the safety, efficacy and convenience for patients and healthcare providers. More information may be found at PlusTherapeutics.com ReSPECT-Trials.com
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