PolyPid to Host Virtual Investor Day on Wednesday, October 28, 2026

PolyPid (Nasdaq: PYPD) will host a virtual Investor Day on October 28, 2026, to outline its long-term growth and pipeline strategy.

Rhea-AI Summary

PolyPid (Nasdaq: PYPD) will host a virtual Investor Day on October 28, 2026, to outline its long-term growth and pipeline strategy. The event begins at 11:30 a.m. ET and will cover “PolyPid 2030.” Management will update investors on D-PLEX₁₀₀, its candidate for preventing colorectal surgical site infections, whose application is under FDA Priority Review with a November 28, 2026 decision goal date. It will also introduce PD01B, being developed for diabetic foot infections using Kynatrix delivery technology.

Specialist Warren S. Joseph will discuss diabetic foot infections and locally delivered antibiotic therapy. A live question-and-answer session with Joseph and management will follow.

News Explained

PolyPid reports that Phase 3 SHIELD II met D-PLEX₁₀₀’s primary endpoint and showed a 60% relative risk reduction at the secondary endpoint for surgical-site infections after abdominal colorectal surgery with large incisions.

Key Terms

new drug application, priority review, pdufa, phase 3

4 terms

new drug application regulatory

"whose New Drug Application (“NDA”) is under U.S. Food and Drug Administration"

A new drug application is a formal request submitted to government regulators seeking approval to market a new medicine. It is like a detailed proposal that shows the drug has been tested for safety and effectiveness. For investors, receiving approval signals that the drug may soon become available for sale, potentially leading to revenue growth and impacting the company's value.

priority review regulatory

"is under U.S. Food and Drug Administration (“FDA”) Priority Review"

Priority review is a regulatory fast-track that shortens the time an agency spends evaluating a drug, vaccine or medical device application so a decision comes sooner than normal. For investors, it matters because a faster review is like an express lane to market: it can speed revenue potential and reduce regulatory uncertainty, but it does not guarantee approval and still requires the product to meet safety and effectiveness standards.

pdufa regulatory

"with a Prescription Drug User Fee Act (“PDUFA”) goal date of November 28, 2026"

PDUFA is the Prescription Drug User Fee Act, the U.S. law under which drug companies pay fees that fund the FDA's review of new medicines. In company news the term usually appears as the PDUFA date, the target deadline by which the FDA aims to decide on a drug application; that date tells investors when to expect the approval or rejection decision for the product.

phase 3 medical

"In the Phase 3 SHIELD II trial, D-PLEX₁₀₀ recently demonstrated positive results"

Phase 3 is the late-stage clinical testing step for a new drug or medical treatment, where the product is given to large groups of patients to confirm effectiveness, monitor side effects, and compare it to standard care. Successful Phase 3 results are often the final scientific hurdle before regulators decide on approval and market launch—like passing a final exam before graduation—and can sharply change a company's valuation and future revenue prospects.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Management to outline ‘PolyPid 2030’, the Company’s long-term vision and pipeline strategy

Event to feature Warren S. Joseph, DPM, FIDSA, a nationally recognized specialist in lower extremity infectious diseases

Petach Tikva, Israel, Oct. 15, 2026 (GLOBE NEWSWIRE) -- PolyPid Ltd. (Nasdaq: PYPD) (“PolyPid” or the “Company”), an innovative biopharmaceutical company dedicated to elevating treatment effectiveness, right where care begins, today announced that it will host a virtual Investor Day on Wednesday, October 28, 2026, at 11:30 a.m. ET.

During the event, PolyPid’s management team will outline the Company’s “PolyPid 2030” long-term growth and pipeline strategy. Management will also provide an update on D-PLEX₁₀₀, the Company’s lead product candidate for the prevention of colorectal surgical site infections, whose New Drug Application (“NDA”) is under U.S. Food and Drug Administration (“FDA”) Priority Review with a Prescription Drug User Fee Act (“PDUFA”) goal date of November 28, 2026, and will introduce PD01B, a new product candidate based on PolyPid’s Kynatrix™ delivery technology, being developed for the treatment of diabetic foot infections.

The event will feature Key Opinion Leader (“KOL”) Warren S. Joseph, DPM, FIDSA, a leading podiatric physician and a specialist in the treatment of lower extremity infections, widely recognized as an authority on the diagnosis and treatment of diabetic foot infections, who will discuss the clinical burden of diabetic foot infections, the limitations of current treatment approaches, and the potential role of locally delivered, controlled-release antibiotic therapy in this setting. A live question-and-answer session with Dr. Joseph and PolyPid’s management team will follow the formal presentations.

Investor Day Dial-In and Webcast Information:

To ensure you are connected prior to the beginning of the event, PolyPid suggests registering a minimum of 5 minutes before the start of the event. For those not planning to ask a question of the Company’s management or Dr. Joseph, the Company recommends listening via the webcast.

Event:	PolyPid 2030: Virtual Investor Day and KOL Event
Date:	Wednesday, October 28, 2026
Time:	11:30 a.m. Eastern Time
Conference Call:	https://register-conf.media-server.com/register/BIb1af168335ad493c80fe51bb064f7b95
Webcast:	https://edge.media-server.com/mmc/p/97rvqcaj

 

The presentation will be available on the Events & Presentations page of the Investors section of the Company’s website at investors.polypid.com on the day of the event. A replay of the event will be available on the same page following the event.

About Warren S. Joseph, DPM, FIDSA

Dr. Warren S. Joseph is a specialist in the treatment of lower extremity infectious diseases. He received his podiatric degree from the Dr. William M. Scholl College of Podiatric Medicine in Chicago, Illinois. Dr. Joseph completed his postgraduate training in podiatric medicine and surgery at St. Joseph’s Hospital, and a fellowship in infectious diseases at Hahnemann University School of Medicine, both in Philadelphia, Pennsylvania. He is currently an Adjunct Clinical Professor at the Arizona College of Podiatric Medicine at Midwestern University in Glendale, AZ.

Dr. Joseph is a fellow of the Infectious Diseases Society of America (IDSA) and is an author on the IDSA Diabetic Foot Infection Guidelines. He is also certified by the American Board of Podiatric Medicine and currently serves as Editor-in-Chief of the Journal of the American Podiatric Medical Association. Dr. Joseph lectures extensively and his presentations have focused on the treatment of bacterial and fungal infections of the lower extremity. He has authored over 100 publications in the field of lower extremity infections.

About D-PLEX₁₀₀
D-PLEX₁₀₀, PolyPid’s lead product candidate, is designed to provide local prolonged and controlled anti-bacterial activity directly at the surgical site with the goal of preventing abdominal surgical site infections (“SSIs”). Following the administration of D-PLEX₁₀₀ into the surgical site, PolyPid’s delivery technology, Kynatrix, is designed to pair with Active Pharmaceutical Ingredients, enabling a prolonged and continuous release of the broad-spectrum antibiotic doxycycline, resulting in a high local concentration of the drug for a period of 30 days for the prevention of SSIs, with additional potential to prevent SSIs caused by antibiotic-resistant bacteria at the surgical site. In the Phase 3 SHIELD II trial, D-PLEX₁₀₀ recently demonstrated positive results in achieving its primary end point and a 60% (p=0.0013) relative risk reduction at the secondary end point in SSI incidence following abdominal colorectal surgery with large incisions. D-PLEX₁₀₀ received Breakthrough Therapy Designation from the U.S. Food and Drug Administration for the prevention of SSIs in patients undergoing elective colorectal surgery.

About PolyPid
PolyPid Ltd. (Nasdaq: PYPD) is an innovative biopharmaceutical company dedicated to elevating treatment effectiveness, right where care begins. The Company develops long-acting, controlled-release drugs designed to deliver therapy precisely at the site of care, addressing critical unmet medical needs across a wide and diverse pipeline spanning surgical care, metabolic diseases, and beyond. PolyPid’s lead product, D-PLEX₁₀₀, successfully met its primary and all key secondary endpoints in the landmark Phase 3 SHIELD II trial for the prevention of surgical site infections. Guided by a commitment to precision and innovation, PolyPid is redefining how therapies perform and raise the standard of patient care. For additional Company information, please visit http://www.polypid.com and follow us on Twitter (X) and LinkedIn.

Forward-Looking Statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act and other securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses the Company’s long-term vision, long-term growth and pipeline strategy, the planned introduction and development of PD01B and its potential role in the treatment of diabetic foot infections, the potential role of locally delivered, controlled-release antibiotic therapy, the PDUFA goal date and the potential FDA approval of D-PLEX₁₀₀. Forward-looking statements are not historical facts, and are based upon management’s current expectations, beliefs and projections, many of which, by their nature, are inherently uncertain. Such expectations, beliefs and projections are expressed in good faith. However, there can be no assurance that management’s expectations, beliefs and projections will be achieved, and actual results may differ materially from what is expressed in or indicated by the forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in the forward-looking statements. For a more detailed description of the risks and uncertainties affecting the Company, reference is made to the Company’s reports filed from time to time with the Securities and Exchange Commission, including, but not limited to, the risks detailed in the Company’s Annual Report on Form 20-F filed on February 25, 2026. Forward-looking statements speak only as of the date the statements are made. The Company assumes no obligation to update forward-looking statements to reflect actual results, subsequent events or circumstances, changes in assumptions or changes in other factors affecting forward-looking information except to the extent required by applicable securities laws. If the Company does update one or more forward-looking statements, no inference should be drawn that the Company will make additional updates with respect thereto or with respect to other forward-looking statements. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. PolyPid is not responsible for the contents of third-party websites.

Company Contact:
PolyPid Ltd.
Ori Warshavsky
908-858-5995
IR@Polypid.com

Investor Relations Contact:
Arx Investor Relations
North American Equities Desk
polypid@arxhq.com