QIAGEN strengthens its portfolio for cancer research, showcasing latest product launches at AACR Annual Meeting 2024
QIAGEN N.V. introduces new products to boost cancer research and liquid biopsy capabilities, including dPCR PanCancer Kits for detecting EGFR and BRAF mutations, a Targeted RNA-seq Panel for T-cell receptors, and a Urine Liquid Biopsy Set for non-invasive sample collection and DNA stabilization.
Positive
Introduction of innovative products to aid cancer research and liquid biopsy techniques.
QIAcuity dPCR PanCancer Kits enable simultaneous detection of EGFR and BRAF mutations, saving time and material.
QIAseq Targeted RNA-seq Panel enhances research on T-cell receptors for cancer immunology.
PAXgene Urine Liquid Biopsy Set allows non-invasive sampling and DNA stabilization for urine liquid biopsy.
Expansion of digital PCR technology for IVD testing with the QIAcuity system.
Positive feedback from researchers and potential applications in cancer detection and treatment monitoring.
The introduction of QIAcuity dPCR PanCancer Kits by QIAGEN represents a significant advancement in the field of oncology research. The ability to detect rare mutations in EGFR and BRAF genes concurrently is a leap forward in precision medicine. Mutations in these genes are pivotal in the development of certain types of cancer and the enhanced sensitivity and specificity offered by these kits could vastly improve early detection and patient stratification for targeted therapies. This technology could also streamline the pre-screening process for NGS, which is a more comprehensive but also more resource-intensive method of analysis. By saving time and sample material and reducing costs, QIAGEN's new kits may increase the efficiency of research and potentially lead to quicker therapeutic interventions.
Furthermore, the potential clinical applications of this technology could be vast. If these assays can be adapted for other cancer-associated genes, the scope of their impact widens. This could eventually lead to more personalized treatment plans and better monitoring of treatment efficacy, which are critical factors in improving patient outcomes. As a result, stakeholders in the biotechnology and pharmaceutical industries should closely monitor the adoption and integration of these tools into clinical practice, as they could influence drug development strategies and partnerships in the oncology space.
The QIAseq Targeted RNA-seq Panel for T-cell Receptors is an innovative tool that addresses a growing interest in the immune system's role in cancer. By enabling a targeted next-generation sequencing approach to T-cell receptor profiling, researchers can gain insights into the adaptive immune response to cancer with high accuracy and sensitivity. This is particularly relevant for understanding tumor microenvironments and could lead to breakthroughs in immunotherapy treatments. The use of unique molecular indices (UMIs) and QIAseq Enrichment Technology ensures that even low-abundance T-cell receptors can be detected, which is important for characterizing the immune repertoire against cancer. This development has implications for personalized medicine, as it could aid in the identification of new therapeutic targets and improve the monitoring of treatment response in cancer patients.
As research in this area progresses, we may see a shift in how immune-based biomarkers are used in clinical trials and treatment planning. This could affect the strategies of companies in the immunotherapy space and potentially lead to collaborations with diagnostic firms like QIAGEN to leverage these advanced analytical capabilities.
The PAXgene Urine Liquid Biopsy Set, developed by PreAnalytiX, a QIAGEN and BD joint venture, is poised to fill a gap in the preanalytical workflow for cell-free DNA in urine (ucfDNA). This non-invasive sampling approach is a critical step forward in the liquid biopsy field. The preservation of ucfDNA from degradation post-collection is crucial, as it ensures the reliability of subsequent analyses. The stabilization of urine samples could lead to more widespread use of urine as a matrix for liquid biopsy, which has been less common compared to blood plasma. This development could facilitate new applications in cancer diagnostics, such as the detection of minimal residual disease and the monitoring of treatment response, which are essential for the management of cancer patients.
The impact on clinical laboratories could be significant, as it may lead to the adoption of new standardized protocols for ucfDNA analysis. This, in turn, could result in the expansion of service offerings and potentially improve the competitiveness of laboratories in the precision diagnostics market. It is also worth noting that the integration of such technologies into routine workflows could pose logistical and technical challenges that will need to be addressed to realize the full potential of urine liquid biopsies.
04/03/2024 - 04:05 PM
Novel QIAcuity dPCR PanCancer Kits can detect rare mutations of EGFR and BRAF genes at the same time, while saving sample material, reducing time and cost // New QIAseq Targeted RNA-seq Panel for T-cell Receptor allows targeted next-generation sequencing of T-cell receptors, increasing accuracy and sensitivity PAXgene® Urine Liquid Biopsy Set to enable non-invasive sample collection and cell-free DNA stabilization, thereby allowing researchers to make advances in urine liquid biopsy
Venlo, the Netherlands, April 03, 2024 (GLOBE NEWSWIRE) -- QIAGEN N.V. (NYSE: QGEN; Frankfurt Prime Standard: QIA) today announced a series of new products to further enhance cancer research as well as to enable urine collection and stabilization as a new approach for liquid biopsy.
These three new products, along with the IVD version of QIAGEN’s digital PCR platform QIAcuity set for launch in mid-2024, are to be featured at the annual meeting of the American Association for Cancer Research (AACR) in San Diego, California, from April 5-10. Two Exhibitor Spotlight Theater sessions and several poster presentations will highlight additional advances from QIAGEN in this field.
“We are excited to share our latest innovation in digital PCR, NGS, and non-invasive sample collection and DNA stabilization with the research community that will help them gain valuable insights into cancer. Our new QIAcuity PanCancer kits will enhance the understanding of EGFR- and BRAF-driven cancers while our QIAcuity IVD system, ready for launch this summer, will translate cancer research into clinical applications and precision diagnostics,” said Nitin Sood, Senior Vice President and Head of QIAGEN’s Life Sciences Business Area. “And with our new solutions for urine liquid biopsy and targeted RNA-sequencing, researchers receive new efficient tools that potentially enable them to better detect minimal residual disease, monitor treatment response, and identify new therapeutic targets.
The new products involve the following:
The newly launched QIAcuity dPCR PanCancer Kits will allow researchers using QIAGEN’s QIAcuity dPCR system to detect multiple EGFR and BRAF hallmark mutations at the same time and with high sensitivity. EGFR and BRAF are genes essential for normal cell growth and function, but mutations in these genes can result in cancer development. The assays clearly discriminate between wild-type and mutant sequences, enhancing specificity and reducing false positives. Researchers can use the kits for pre-screening samples before, for example, analyzing them with NGS, or monitoring cancer cells. Simultaneously assessing the mutations, they reduce time and cost and save on sample material. The technology has the potential to be adapted to identify other genes associated with cancer risks. “I am testing the novel PanCancer Assays on the QIAcuity instrument using FFPE tissue samples and liquid biopsies to concurrently detect multiple hallmark mutations in BRAF and EGFR – and initial findings have convinced me that this product has the potential to accelerate prognostic and predictive biomarker analysis, early mutation detection and screenings,” said Vijayalakshmi Ramshankar, Professor and Head of the Department of Preventive Oncology Research, Cancer Institute (WIA), Chennai, India.
To advance research on how the immune system interacts with cancer, QIAGEN has introduced the QIAseq Targeted RNA-seq Panel for T-cell receptors . T-cell receptors play a crucial role in the adaptive immune system, which is responsible for recognizing and eliminating abnormal cells, such as cancer cells. The panel uses unique molecular indices (UMI) with QIAseq Enrichment Technology to facilitate ultrasensitive and accurate characterization of the immune repertoire in human and mouse from low input and FFPE samples. It enables targeted NGS detection of the human or mouse expressed T cell receptors (TCR): TCR-alpha, TCR-beta, TCR-gamma and TCR-delta. This library prep kit will accelerate research into several areas with high accuracy and sensitivity, among them how the T-cell receptor repertoire in cancer can be used as a biomarker and how the repertoire of tumor-infiltrating T-cells can improve the understanding of tumor behavior. The PAXgene Urine Liquid Biopsy Set currently being developed by PreAnalytiX, a QIAGEN and BD joint venture, will launch later this year. It will provide an easy-to-use, non-invasive sampling approach to liquid biopsy and address current preanalytical workflow gaps for cell-free DNA in urine (ucfDNA). By introducing preservatives into urine samples, it will prevent the rapid, post-collection degradation of ucfDNA and minimize the release of potentially misleading genomic DNA, both of which can make ucfDNA analysis unreliable or even impossible. Urine liquid biopsy research holds significant potential for applications such as detecting minimal residual disease, monitoring treatment response and identifying therapeutic targets, complementing the results of blood plasma analysis and offering a more comprehensive understanding of the tumor. Professor Ellen Heitzer of the Diagnostic and Research Institute of Human Genetics at the Medical University of Graz in Austria will present the results of her study with the PAXgene technology in an Exhibitor Spotlight Theater session: “Cell-free DNA isolated from urine offers a truly non-invasive sampling method for liquid biopsy, but ucfDNA requires careful sample handling. The urine collection and stabilization solution enables optimized standardized workflows. This makes several downstream analyses feasible with ucfDNA and can provide important complementary information.”
QIAGEN will also highlight at the AACR meeting the upcoming launch of the QIAcuity system for IVD testing – the expansion of its digital PCR technology from research to the clinical setting. The QIAcuityDx system offers a custom assay development environment alongside IVD functionality, providing labs with a simplified yet regulatory-compliant route to run IVD assays or lab-developed tests (LDTs) and generate results within the same working day.
Learn more about QIAGEN’s offering at the AACR Annual Meeting 2024, (booth #922 in the San Diego Convention Center) and poster presentations highlighting new solutions in digital PCR, NGS and preanalytical workflows at https://www.qiagen.com/applications/cancer-research/aacr-2024-annual-meeting .
About PreAnalytiX, GmbH
PreAnalytiX was formed in 1999 by QIAGEN and BD with the purpose of developing, manufacturing, and marketing integrated systems for the collection, stabilization, and purification of nucleic acids (DNA and RNA) for molecular diagnostic testing. More information about PreAnalytiX can be found at https://www.preanalytix.com .
About QIAGEN
QIAGEN N.V., a Netherlands-based holding company, is the leading global provider of Sample to Insight solutions that enable customers to gain valuable molecular insights from samples containing the building blocks of life. Our sample technologies isolate and process DNA, RNA and proteins from blood, tissue and other materials. Assay technologies make these biomolecules visible and ready for analysis. Bioinformatics software and knowledge bases interpret data to report relevant, actionable insights. Automation solutions tie these together in seamless and cost-effective workflows. QIAGEN provides solutions to more than 500,000 customers around the world in Molecular Diagnostics (human healthcare) and Life Sciences (academia, pharma R&D and industrial applications, primarily forensics). As of December 31, 2023, QIAGEN employed approximately 6,000 people in over 35 locations worldwide. Further information can be found at http://www.qiagen.com
Forward-Looking Statement
Certain statements contained in this press release may be considered forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933, as amended, and Section 21E of the U.S. Securities Exchange Act of 1934, as amended. To the extent that any of the statements contained herein relating to QIAGEN's products, timing for launch and development, marketing and/or regulatory approvals, financial and operational outlook, growth and expansion, collaborations, markets, strategy or operating results, including without limitation its expected adjusted net sales and adjusted diluted earnings results, are forward-looking, such statements are based on current expectations and assumptions that involve a number of uncertainties and risks. Such uncertainties and risks include, but are not limited to, risks associated with management of growth and international operations (including the effects of currency fluctuations, regulatory processes and dependence on logistics), variability of operating results and allocations between customer classes, the commercial development of markets for our products to customers in academia, pharma, applied testing and molecular diagnostics; changing relationships with customers, suppliers and strategic partners; competition; rapid or unexpected changes in technologies; fluctuations in demand for QIAGEN's products (including fluctuations due to general economic conditions, the level and timing of customers' funding, budgets and other factors); our ability to obtain regulatory approval of our products; difficulties in successfully adapting QIAGEN's products to integrated solutions and producing such products; the ability of QIAGEN to identify and develop new products and to differentiate and protect our products from competitors' products; market acceptance of QIAGEN's new products and the integration of acquired technologies and businesses; actions of governments, global or regional economic developments, weather or transportation delays, natural disasters, political or public health crises, and its impact on the demand for our products and other aspects of our business, or other force majeure events; as well as the possibility that expected benefits related to recent or pending acquisitions may not materialize as expected; and the other factors discussed under the heading “Risk Factors” contained in Item 3 of our most recent Annual Report on Form 20-F. For further information, please refer to the discussions in reports that QIAGEN has filed with, or furnished to, the U.S. Securities and Exchange Commission.
Source: QIAGEN
What new products has QIAGEN introduced for cancer research and liquid biopsy?
QIAGEN has launched dPCR PanCancer Kits, a Targeted RNA-seq Panel for T-cell receptors, and a Urine Liquid Biopsy Set.
What is the purpose of the QIAcuity dPCR PanCancer Kits?
The kits allow simultaneous detection of EGFR and BRAF mutations, enhancing specificity and reducing false positives.
What is the significance of the QIAseq Targeted RNA-seq Panel?
It aids research on T-cell receptors for cancer immunology with high accuracy and sensitivity.
How does the PAXgene Urine Liquid Biopsy Set contribute to liquid biopsy?
It enables non-invasive sample collection and DNA stabilization for urine liquid biopsy.
What is the key feature of the QIAcuity system for IVD testing?
It expands digital PCR technology for clinical applications and provides regulatory-compliant assay development.
