Revolution Medicines to Present Clinical Data from RAS(ON) Inhibitor Combination Trials in Pancreatic Cancer at ESMO Gastrointestinal Cancers Congress 2026
Rhea-AI Summary
Revolution Medicines (RVMD) will present new clinical data from its RAS(ON) inhibitor combination trials in pancreatic cancer at the ESMO Gastrointestinal Cancers Congress 2026, July 1–4 in Munich.
The program features two Phase 1/2 zoldonrasib combination orals and two Phase 3 RASolute trial posters in PDAC.
Positive
- None.
Negative
- None.
News Market Reaction – RVMD
In the Jun 25 session, RVMD gained 4.95%, reflecting a moderate positive market reaction. Argus tracked a peak move of +4.2% during that session. Our momentum scanner triggered 52 alerts that day, indicating high trading interest and price volatility.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Previous Clinical trial Reports
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Jun 23 | Phase 3 trial start | Positive | +2.2% | Began treating patients in Phase 3 RASolute 305 in metastatic PDAC. |
| May 31 | Pivotal Phase 3 data | Positive | +3.9% | Reported RASolute 302 Phase 3 daraxonrasib data with strong survival benefit. |
| May 06 | Phase 1/2 publication | Positive | -5.7% | NEJM publication of daraxonrasib Phase 1/2 pancreatic cancer results supporting Phase 3. |
| Apr 21 | Phase 1/2 update | Positive | -4.4% | Updated Phase 1/2 daraxonrasib first-line mPDAC data at AACR 2026. |
| Apr 21 | Planned Phase 3 readout | Positive | +1.8% | Announced upcoming ASCO plenary for detailed RASolute 302 Phase 3 results. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Clinical trial news has produced mixed reactions, with a slight tendency toward small average declines despite generally positive data.
Key Terms
pancreatic ductal adenocarcinoma medical
adjuvant medical
neoadjuvant medical
open-label medical
monotherapy medical
randomized medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
REDWOOD CITY, Calif., June 24, 2026 (GLOBE NEWSWIRE) -- Revolution Medicines, a late-stage clinical oncology company developing targeted therapies for patients with RAS-addicted cancers, today announced that four oral and poster presentations highlighting data from its RAS(ON) pipeline will be featured at the 2026 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Congress, taking place July 1–4, 2026 in Munich, Germany.
The program will include two oral presentations from Phase 1/2 trials evaluating zoldonrasib, an oral RAS(ON) G12D-selective covalent inhibitor, in combination regimens for patients with metastatic RAS G12D pancreatic ductal adenocarcinoma (PDAC). These presentations will report results from zoldonrasib plus chemotherapy in the first line setting, and zoldonrasib plus daraxonrasib, the company’s oral RAS(ON) multi-selective inhibitor, in patients who had received one or more prior lines of therapy.
Additional presentations will include two Phase 3 trials-in-progress posters for RASolute 303, evaluating daraxonrasib as a monotherapy or in combination with gemcitabine and nab-paclitaxel versus standard of care gemcitabine and nab-paclitaxel as a first line treatment for patients with metastatic PDAC, and RASolute 304, evaluating adjuvant daraxonrasib in patients with PDAC who have undergone resection and completed perioperative chemotherapy.
Details of Revolution Medicines’ presentations are listed below.
Revolution Medicines Oral Presentations:
| Title: | Safety and Efficacy of Zoldonrasib (RMC-9805) Plus Chemotherapy in Patients (pts) with 1L RAS G12D Metastatic Pancreatic Adenocarcinoma (mPDAC) |
| Abstract: | #340O |
| Presenter: | Brian Wolpin, M.D., Dana-Farber Cancer Institute |
| Session: | Proffered Paper Session |
| Date/Time: | July 2; 2:40 p.m. – 2:50 p.m. CEST |
| Title: | Safety and Efficacy of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) in Patients with 2L+ KRAS G12D Metastatic Pancreatic Adenocarcinoma (mPDAC) |
| Abstract: | #341O |
| Presenter: | Nilofer Azad, M.D., Johns Hopkins Sidney Kimmel Comprehensive Cancer Center |
| Session: | Proffered Paper Session |
| Date/Time: | July 2; 2:50 p.m. – 3:00 p.m. CEST |
Revolution Medicines Posters:
| Title: | RASolute 303: A Phase 3 Global, Multicenter, Open-Label, Randomized 3-Arm Study of Daraxonrasib Monotherapy or Daraxonrasib Plus Gemcitabine and Nab-paclitaxel Versus Gemcitabine and Nab-paclitaxel as a First Line Treatment for Patients With Metastatic Pancreatic Adenocarcinoma |
| Abstract: | #471TiP |
| Presenter: | Thomas Seufferlein, M.D., Ph.D., University Hospital Ulm |
| Session: | Upper Digestive – Biliary, ampullary and pancreatic cancer |
| Date/Time: | July 3; 3:30 p.m. – 4:30 p.m. CEST |
| Title: | RASolute 304 – A Phase 3 Multicenter, Open-label, Randomized Study of Adjuvant Daraxonrasib Versus Observation Following Completion of Neoadjuvant and/or Adjuvant Chemotherapy in Patients With Resected Pancreatic Adenocarcinoma (PDAC) |
| Abstract: | #472TiP |
| Presenter: | Michel Ducreux, M.D., Ph.D., Institut Gustave Roussy |
| Session: | Upper Digestive – Biliary, ampullary and pancreatic cancer |
| Date/Time: | July 3; 3:30 p.m. – 4:30 p.m. CEST |
About Revolution Medicines, Inc.
Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. Additional development opportunities in the company’s pipeline focus on RAS(ON) mutant-selective inhibitors, including RMC-0708 (Q61H) and RMC-8839 (G13C). For more information, please visit www.revmed.com and follow us on LinkedIn.
Forward Looking Statements
This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this press release that are not historical facts may be considered “forward-looking statements,” including without limitation statements regarding the progression of clinical studies and findings from these studies, including the tolerability, safety, and potential efficacy of the company’s candidates being studied.
Forward-looking statements are typically, but not always, identified by the use of words such as “aims,” “anticipate,” "believe," "estimate," "expect," "plan," “potential,” “project,” “up to,” "will" and other similar terminology indicating future results. Such forward-looking statements are subject to substantial risks and uncertainties that could cause the company’s development programs, future results, performance, or achievements to differ materially from those anticipated in the forward-looking statements. Such risks and uncertainties include without limitation risks and uncertainties inherent in the drug development process, including the company’s programs’ development stages, the process of designing and conducting preclinical and clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, the company’s ability to successfully establish, protect and defend its intellectual property, other matters that could affect the sufficiency of the company’s capital resources to fund operations, reliance on third parties for manufacturing and development efforts, changes in the competitive landscape, and the effects on the company’s business of the global events, such as international conflicts or global pandemics. For a further description of the risks and uncertainties that could cause actual results to differ from those anticipated in these forward-looking statements, as well as risks relating to the business of Revolution Medicines in general, see Revolution Medicines’ Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the “SEC”) on May 6, 2026, and its future periodic reports to be filed with the SEC. Except as required by law, Revolution Medicines undertakes no obligation to update any forward-looking statements to reflect new information, events, or circumstances, or to reflect the occurrence of unanticipated events.
Revolution Medicines Media & Investor Contact:
media@revmed.com
investors@revmed.com
