Sana Biotechnology, Inc. develops engineered cells as medicines for patients, with programs that apply cell engineering, hypoimmune platform technology, and fusogen-based delivery. News about SANA commonly covers its type 1 diabetes cell-replacement work, including UP421 and SC451, and its in vivo CAR T program SG293 for CD19-directed therapy in B-cell cancers and B-cell-mediated autoimmune diseases.
Company updates also include preclinical and clinical data presentations, research collaborations, manufacturing and regulatory preparation, financial results, equity financing activity, executive appointments, and investor conference presentations.
Cellarity has appointed Dr. Sandra Horning to its Board of Directors. Dr. Horning, former Chief Medical Officer at Roche, has extensive experience in drug development, having led the approval of 15 new medicines. Her role is expected to strengthen Cellarity's mission of transforming drug creation through innovative approaches that address complex diseases. The company's unique methodologies utilize high-resolution data and machine learning to enhance drug discovery. This strategic move is viewed positively for future product development.
Sana Biotechnology, Inc. (NASDAQ: SANA) announced that it will webcast its presentation at the BofA Securities 2022 Healthcare Conference on May 11, 2022, at 3:20 p.m. PT. The presentation will include a business overview by Steve Harr, President and CEO. Investors can access the live webcast on Sana's Investor Relations page, with a replay available for 30 days post-event. Sana focuses on engineered cells as medicines, aiming to repair genes and replace damaged cells, with operations in multiple U.S. locations.
Sana Biotechnology, Inc. (NASDAQ: SANA) announced the acceptance of five abstracts for presentation at the ASGCT 25th Annual Meeting in Washington, D.C. from May 16-19, 2022. The abstracts include two oral presentations on their hypoimmune platform, which aims to enable allogeneic cell transplants without the need for immunosuppression, and two poster presentations on their fusogen platform for targeted gene delivery. The company plans to file two Investigational New Drug applications within the year, focusing on translating their scientific advancements into viable therapeutics.
Tessera Therapeutics has secured over $300 million in Series C financing to advance its GENE WRITING technology aimed at curing genetic diseases. Investors include the Abu Dhabi Investment Authority and Alaska Permanent Fund Corporation. CEO Geoffrey von Maltzahn emphasizes the transformative potential of genetic medicine. The GENE WRITING platform enables precise modifications to DNA, unlocking new treatment possibilities for various conditions. Tessera's innovative approach positions it to potentially lead a new category in genetic medicine.
Sana Biotechnology, Inc. (NASDAQ: SANA) reported a strong cash position of $746.9 million as of December 31, 2021, up from $412.0 million in 2020, driven by a successful IPO. The company is advancing its pipeline, anticipating two IND applications in 2022 for its CAR T programs, SC291 and SG295. Additionally, Sana made significant progress in research and development, including partnerships for stem cells and gene editing. However, the net loss for 2021 was $355.9 million, or $2.14 per share, indicating ongoing financial challenges as they scale operations and clinical trials.
Sana Biotechnology, Inc. (NASDAQ: SANA) announced its participation in the 32nd Annual Oppenheimer Healthcare Conference, scheduled for March 16, 2022, at 6:20 a.m. PT. The event will feature a presentation by CEO Steve Harr, providing a business overview and updates. The webcast can be accessed on the company's Investor Relations page, with a replay available for 30 days post-conference. Sana is focused on developing engineered cell therapies aimed at changing disease treatment.
Sana Biotechnology, Inc. (NASDAQ: SANA) announced preclinical data from its hypoimmune T cell program, set to be presented at the 2022 AACR Annual Meeting from April 8-13 in New Orleans. The hypoimmune platform allows for allogeneic cell transplants without immunosuppression, demonstrating CAR T cells that evade immune response while maintaining anti-tumor efficacy. Sana plans to file investigational new drug applications for its CD19-expressing CAR T cell therapies, starting with SC291 in 2022 and SC276 in 2023.
Cellarity has announced key appointments to its executive team, enhancing its expertise in drug development. Laurens Kruidenier, Ph.D., joins as Chief Scientific Officer to lead drug platform evolution, while Anna O’Driscoll becomes Chief People Officer to drive talent development. Parul Doshi is appointed Senior VP, Head of Data and Software Engineering to bolster data infrastructure. These changes underscore Cellarity's commitment to advancing its drug creation process, particularly its unique approach that examines cellular changes underlying diseases, applicable across multiple therapeutic areas.
Sana Biotechnology (NASDAQ: SANA) has secured an exclusive worldwide license from the National Cancer Institute for the CD22 chimeric antigen receptor (CAR) technology. This agreement focuses on enhancing engineered T cell therapies for B cell malignancies, particularly addressing relapse challenges associated with current CD19-directed CAR therapies. With promising clinical data supporting the efficacy of CD22 CAR, Sana aims to improve outcomes for patients suffering from B cell malignancies, including non-Hodgkin lymphoma and acute lymphoblastic leukemia. Financial terms include upfront payments, milestone payments, and royalties on sales.
Sana Biotechnology has entered an agreement with IASO Biotherapeutics and Innovent Biologics to obtain non-exclusive commercial rights to a clinically validated BCMA CAR construct. This construct, part of an autologous CAR T cell therapy, has shown promising results for treating relapsed/refractory multiple myeloma, with a 94.9% overall response rate reported in clinical trials. The deal includes an upfront payment and potential milestone payments totaling up to $204 million.