Splash Beverage Group Partners with Veteran Cannabinoid Drug-Development Team to Advance CannEpil® Through FDA Veterinary Pathway
Rhea-AI Summary
Splash Beverage Group (NYSE American: SBEV) entered a strategic development and collaboration agreement with Lupvindol Biosciences to advance CannEpil as a potential FDA-regulated veterinary pharmaceutical for companion-animal oncology and chronic pain, initially focusing on canine applications through the FDA Center for Veterinary Medicine’s INAD and potential Conditional Approval pathway.
Lupvindol will lead scientific, product-development and regulatory activities, while Splash provides milestone-based funding, leads commercialization and capital-markets strategy, and will own the medical technology, study data, regulatory submissions and foreground IP, retaining future licensing and commercialization control. The agreement aligns payments with defined regulatory milestones; Lupvindol will cover FDA sponsor fees through Conditional Approval, and Splash will fund any FDA-required pilot study subject to a contractual cap. Splash licenses CannEpil from Argent Biopharma and is repositioning itself as a diversified cannabinoid health, wellness and biopharmaceutical platform. CannEpil is not FDA-approved for veterinary use, and there is no assurance of approval.
Positive
- Strategic FDA-pathway collaboration with Lupvindol for CannEpil veterinary development
- Splash retains ownership of study data, regulatory submissions and foreground IP
- Milestone-based funding structure aligns cash outlay with regulatory progress
- Lupvindol absorbs FDA sponsor fees through Conditional Approval stage
- Targets large vet pain market projected at $3.8 billion by 2030
- Access to experienced cannabinoid team with prior Epidiolex and Sativex involvement
Negative
- CannEpil not FDA-approved for veterinary use; approval is uncertain
- Splash funds FDA-required pilot study subject to a contractual cap
- Regulatory, cost and timeline outcomes depend on future FDA engagement
News Explained
The entered collaboration creates milestone-based funding obligations for Splash, while its latest reported
Sources and calculations
- Splash Beverage Group CannEpil collaboration release (2026-08-05)
- Splash Beverage Group latest-quarter fundamentals (2026Q1)
- Cash and equivalents vs quarterly operating cash outflow, in days of cash use $381,195 / ($930,492 / 90) = [object Object]
Market reaction after veterinary development partnership: SBEV +18.94%
Following this news, SBEV has gained 18.94%, reflecting a significant positive market reaction. Argus tracked a peak move of +24.5% during the session. Our momentum scanner has triggered 59 alerts so far, indicating high trading interest and price volatility. The stock is currently trading at $0.42.
Data tracked by StockTitan Argus (15 min delayed). Upgrade to Gold for real-time data.
Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Jul 14 | Reverse stock split | Positive | -15.9% | Balance-sheet settlements and board approval of a one-for-four reverse stock split |
| Jul 09 | Listing compliance | Positive | -5.0% | NYSE American accepted the compliance plan through January 29, 2027 |
| Jul 07 | CannEpil license | Positive | -23.2% | Splash announced exclusive global CannEpil rights and development access |
| Jul 06 | CannEpil license | Positive | +42.5% | Splash signed an exclusive global license including financing and royalty terms |
| Jun 15 | Avicanna investment | Positive | +0.1% | Splash completed a strategic investment in cannabinoid biopharmaceutical company Avicanna |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Recent positive corporate announcements were more often followed by negative 24-hour price reactions than aligned reactions.
Key Terms
conditional approval regulatory
good manufacturing practice technical
tetrahydrocannabinol medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
Collaboration with Lupvindol Biosciences will initially target companion-animal oncology and chronic pain management
Splash retains ownership of resulting data, intellectual property and commercialization rights
FORT LAUDERDALE, Fla., Aug. 05, 2026 (GLOBE NEWSWIRE) -- Splash Beverage Group, Inc. (NYSE American: SBEV) (“Splash” or the “Company”) today announced that it has entered into a strategic development and collaboration agreement with Lupvindol Biosciences Ltd. to advance CannEpil® as a potential FDA-regulated veterinary pharmaceutical product for companion-animal oncology and chronic pain management.
The milestone-driven program is designed to advance CannEpil through the U.S. Food and Drug Administration’s Center for Veterinary Medicine, beginning with the Investigational New Animal Drug (“INAD”) process and progressing toward potential conditional approval pursuant to Section 571 of the Federal Food, Drug, and Cosmetic Act (“Conditional Approval”). Canine applications are expected to represent the initial development focus.
Lupvindol will lead the scientific, product-development and FDA regulatory activities, including preparation of the INAD submission, development of an FDA-acceptable product development plan, study design and oversight, regulatory correspondence and preparation of a potential Conditional Approval submission.
Splash will provide milestone-based funding and lead commercialization strategy, strategic partnering and capital-markets activities. Importantly, Splash will own the medical technology, study data, regulatory submissions and foreground intellectual property generated through the collaboration and will retain control over future licensing and commercialization decisions.
“This collaboration converts our expanded CannEpil rights into a defined and capital-efficient FDA development program,” said Brady Cobb, Interim Chief Executive Officer of Splash Beverage Group. “Our objective is to build a differentiated cannabinoid health sciences platform by pairing high-quality intellectual property with experienced scientific leadership, disciplined regulatory execution and global commercial capabilities.”
“The Lupvindol team has helped advance cannabinoid medicines from development through FDA approval and commercialization. By combining that experience with Splash’s exclusive global CannEpil rights, we believe we have assembled the assets and leadership necessary to pursue a significant opportunity in companion-animal health while preserving Splash’s ownership of the value created through the program.”
EXPERIENCED CANNABINOID PHARMACEUTICAL LEADERSHIP
The program will be led by Hunter Land, Ph.D., Chief Executive Officer of Lupvindol Biosciences, a pharmaceutical research and development executive with more than two decades of experience across multiple therapeutic areas.
Dr. Land was GW Pharmaceuticals’ first full-time U.S. research and development employee and played an important role in the development of Epidiolex®, the first FDA-approved plant-derived cannabinoid medicine, as well as Sativex®. His experience includes cannabinoid pharmaceutical development, clinical protocol design, regulatory strategy and commercialization planning.
The broader Lupvindol team brings experience in FDA regulatory pathways, cannabinoid science, preclinical and clinical study design, product development and commercialization.
“Having participated in the development of Epidiolex®, I have seen firsthand how rigorous science, disciplined execution and thoughtful regulatory engagement can transform cannabinoid research into approved pharmaceutical products,” said Dr. Land.
“CannEpil represents a differentiated pharmaceutical cannabinoid platform that we believe warrants evaluation through the FDA’s veterinary regulatory framework. Our team looks forward to working with Splash to generate the scientific and clinical evidence required to support potential approval and commercialization in companion-animal oncology and chronic pain management.”
CAPITAL-EFFICIENT DEVELOPMENT MODEL
The agreement aligns Splash’s investment with measurable regulatory progress through an initial payment followed by milestone payments tied to opening the INAD, completing the product development plan, advancing FDA submissions and achieving Conditional Approval or an earlier licensing transaction.
Lupvindol will absorb the annual FDA sponsor fee through Conditional Approval, unless the parties agree to transfer sponsorship. Splash will fund any FDA-required pilot study subject to an agreed development plan and contractual funding cap.
Following a designated FDA submission milestone, Splash will evaluate regulatory feedback, remaining development requirements and interest from potential animal-health pharmaceutical partners before determining the next phase of the program.
Splash will retain lead responsibility for commercialization and may elect to partner with an established animal-health pharmaceutical company or pursue direct commercialization based on the regulatory and commercial data available at that time.
Additional information regarding the collaboration agreement, including an overview of material terms and a copy of the agreement as an exhibit, will be contained in a Current Report on Form 8-K which the Company will file with the Securities and Exchange Commission.
The Company licenses CannEpil from Argent Biopharma Limited pursuant to an Exclusive License Agreement dated July 6, 2026, as amended on July 27, 2026.
COMPANION-ANIMAL HEALTH OPPORTUNITY
The global veterinary pain-management market was valued at approximately
“Splash is executing a disciplined strategy to build a diversified cannabinoid health sciences platform by commercializing existing international pharmaceutical assets, advancing FDA-regulated veterinary and human therapeutics, and developing innovative cannabinoid consumer wellness and beverage brands for global markets,” Cobb said.
“We have secured the asset, expanded its licensed field and now engaged an experienced cannabinoid drug-development team to execute the veterinary program. Our focus is achieving measurable regulatory and commercial milestones.”
CannEpil has not been approved by the FDA for veterinary use. The indications, study designs, regulatory requirements, costs and development timeline will be determined through engagement with the FDA. There can be no assurance that CannEpil will receive Conditional Approval, full approval or any other regulatory authorization.
About Lupvindol Biosciences Ltd.
Lupvindol Biosciences Ltd. is a pharmaceutical and bioscience development company with expertise in cannabinoid-based therapeutics and U.S. FDA regulatory pathways. The company is led by Hunter Land, Ph.D., whose experience includes participation in the development of Epidiolex® and Sativex® at GW Pharmaceuticals.
About CannEpil®
CannEpil® is a proprietary pharmaceutical-grade formulation comprising cannabidiol and tetrahydrocannabinol isolates in a liquid solution manufactured under European Union Good Manufacturing Practice standards. CannEpil was originally developed for drug-resistant epilepsy in humans and has previously been made accessible through certain physician-directed and special-access pathways outside the United States.
About Splash Beverage Group, Inc.
About Splash Beverage Group, Inc.
Splash Beverage Group, Inc. (NYSE American: SBEV) is a publicly traded company headquartered in Fort Lauderdale, Florida. The Company is pursuing a strategic transformation toward becoming a cannabinoid health, wellness, and biopharmaceutical platform through disciplined capital allocation, strategic investments, acquisitions, and other platform-building initiatives.
More Information
Contact Information
Splash Beverage Group
Info@SplashBeverageGroup.com
Media Contact
Angela Gorman
AMWPR
angela@amwpr.com
917-348-0083
Forward-Looking Statements
This press release contains forward-looking statements, including statements regarding CannEpil’s veterinary development; potential oncology and chronic pain indications; the INAD and Conditional Approval processes; anticipated studies, FDA interactions and regulatory submissions; potential licensing and commercialization arrangements; and Splash’s broader business strategy.
Forward-looking statements involve risks and uncertainties that could cause actual results to differ materially, including Splash’s ability to raise the necessary capital to finance the program, satisfy its contractual obligations including our ability to maintain the license under the license agreement for the CannEpil product on which the collaboration described herein depends, complete required studies, establish product safety and efficacy, obtain regulatory authorization, protect intellectual property and the risk that competitors market the same or similar products, and execute commercialization or strategic-partnering arrangements, and the risk that that the market or demand for any resulting product we seek to commercialize in the future could be less than expected or projected. There can be no assurance that an INAD will be opened, any development milestone will be achieved, CannEpil will receive regulatory approval or any initiative will generate revenue.
Additional risks are described in Splash’s filings with the Securities and Exchange Commission, including its Annual Report on Form 10-K for the year ended December 31, 2025 and the Final Prospectus on Form 424B3 filed on June 26, 2026. Splash undertakes no obligation to update forward-looking statements except as required by law.
