Schrödinger Reports First Quarter 2026 Financial Results
Key Terms
adjusted EBITDA financial
non-GAAP financial
free-energy perturbation (FEP+) medical
Phase 1 medical
Fast Track regulatory
Orphan Drug Designations regulatory
Rule 10b5-1 regulatory
GLP-1 receptor agonist medical
First Quarter ACV of
Continued Momentum in Transition to Hosted Software Licensing
Schrödinger to Launch Bunsen, an Agentic AI Co-Scientist, This Summer
Lilly’s Announced
“Our first quarter results show strong growth in both ACV and drug discovery revenue. ACV growth of 12 percent was driven by usage scale-ups and new deployments; we are also pleased with our progress transitioning customers to hosted licensing. The biopharmaceutical funding environment is improving, and the depth of customer engagement reflects the critical importance of our computational platform that integrates ground truth simulation with leading edge AI. We have a strong commitment to technology leadership and are excited about the release this summer of Bunsen, an agentic AI co-scientist designed to autonomously execute complex molecular discovery workflows and expand utilization to a broader user base,” said Ramy Farid, Ph.D., chief executive officer of Schrödinger. “We also continue to see the impact of our platform through the success of our co-founded companies. Lilly’s announced acquisition of Ajax Therapeutics, in which we have an approximately six percent equity stake, marks another multi-billion dollar acquisition of a Schrödinger co-discovered molecule. This milestone reinforces the strength of our platform, team and integrated business model.”
First Quarter 2026 Operating and Financial Highlights (comparisons are to first quarter 2025, unless otherwise noted)
-
ACV was
$28.4 million 12% increase, and$201 million -
Software revenue was
$35.6 million 21% decrease, reflecting the company’s planned accelerated transition to hosted software licensing. -
Drug discovery revenue was
$22.9 million $10.2 million -
Contribution revenue was
$0.1 million $4.3 million -
Total revenue was
$58.6 million 2% decrease. -
Software gross margin was
69% , reflecting the company’s planned accelerated transition to hosted software licensing. -
Operating expenses were
$78.3 million 4% decrease. -
Other expenses, which include changes in fair value of equity investments and interest income/expense, were
$10.8 million -
Net loss was
$60.0 million $59.8 million -
Cash, cash equivalents, restricted cash and marketable securities were
$406 million
Schrödinger now presents contribution revenue and cost of revenue separately from software and drug discovery revenue and cost of revenues. Prior periods have been reclassified to conform to this presentation to facilitate year-over-year comparability.
2026 Financial and Operational Outlook
As of May 5, 2026, Schrödinger maintained its previously issued financial guidance for the fiscal year ending December 31, 2026:
-
ACV is expected to range from
$218 million $228 million -15% growth over 2025. -
Drug discovery revenue is expected to range from
$55 million $65 million - Operating expenses are expected to be less than 2025.
For the second quarter of 2026, ACV is expected to range from
Recent Highlights
Platform
- Today Schrödinger announced plans for release of an early-access version of Bunsen, its new agentic AI co-scientist, this summer. Bunsen autonomously executes complex molecular discovery workflows, expanding the user base and enhancing productivity across Schrödinger’s industry-leading computational platform. Bunsen allows for greater throughput and utilization of Schrödinger’s predict-first approaches, accelerating discovery timelines and improving project outcomes. Schrödinger’s materials science and therapeutics teams have been using Bunsen internally to enhance productivity across research projects.
- In April, researchers at Schrödinger and Bristol Myers Squibb published the discovery of a series of potent sterile alpha and TIR motif containing 1 (SARM1) inhibitors as a potential treatment for neurodegenerative diseases. The inhibitors were identified through a unique workflow for free-energy perturbation (FEP+). This computational approach identified molecules with unique binding properties while establishing precise dose levels to optimize safety profiles.
- In March, researchers at Schrödinger and Lilly published a simulation method that predicts the viscosity and injectability of antibody-based drugs by mapping interactions between individual amino acids. This computational approach replaces resource-intensive physical experiments by identifying the specific points of contact where proteins interact with one another. By computationally determining how different additives improve drug consistency, the new method can significantly accelerate the development of subcutaneous treatments.
Therapeutics Portfolio
-
In April, Ajax Therapeutics, a company co-founded by Schrödinger, announced its sale to Lilly for up to
$2.3 billion 5.8% equity stake in Ajax.
-
Schrödinger is exploring strategic partnerships for mid-and late-stage development of SGR-1505, its differentiated MALT1 inhibitor, and SGR-3515, its Wee1/Myt1 dual inhibitor. In April, Schrödinger presented preliminary Phase 1 clinical data for SGR-3515 at the American Association for Cancer Research (AACR) Annual Meeting. The initial data demonstrated that SGR-3515 was generally well-tolerated on an intermittent dosing schedule and achieved a
65% disease control rate among evaluable participants at doses of 100 mg or higher.
Data most recently presented at the American Society of Hematology (ASH) Annual Meeting demonstrated that SGR-1505 was generally well tolerated and clinically active in patients with relapsed/refractory B-cell malignancies, including a100% response rate in patients with Waldenström macroglobulinemia (WM). SGR-1505 has FDA Fast Track and Orphan Drug Designations for WM.
- In March, Structure Therapeutics, a collaborator and company co-founded by Schrödinger, announced positive topline results from its Phase 2 clinical program for aleniglipron, its once-daily oral GLP-1 receptor agonist for the treatment of obesity. Schrödinger has an equity stake in Structure.
Webcast and Conference Call Information
Schrödinger will host a conference call to discuss its first quarter 2026 financial results on Tuesday, May 5, 2026, at 4:30 p.m. ET. The live webcast can be accessed under “Events & Presentations" in the investors section of Schrödinger’s website, https://ir.schrodinger.com/news-and-events/event-calendar. To participate in the live call, please register for the call here. It is recommended that participants register at least 15 minutes in advance of the call. Once registered, participants will receive the dial-in information. The archived webcast will be available on Schrödinger’s website for approximately 90 days following the event.
Non-GAAP Information
Included in this press release is certain financial information that has not been prepared in accordance with generally accepted accounting principles in
Management believes adjusted EBITDA is a useful measure for investors, taken in conjunction with the company’s GAAP financial statements because they provide greater period-over-period comparability with respect to the company’s operating performance, by excluding the effects of capital structure, tax impacts, non-cash depreciation and amortization, non-cash equity compensation expense, non-cash mark-to-market and other valuation adjustments for the company’s equity investments, non-recurring cash distributions from the company’s equity investments, and other non-recurring items that are not reflective of the ongoing performance of the business. However, adjusted EBITDA as a non-GAAP financial measure should be considered only in addition to, not as a substitute for or as superior to, net income (loss) or other financial measures prepared in accordance with GAAP.
Other companies in Schrödinger’s industry may calculate adjusted EBITDA differently than Schrödinger does, limiting their usefulness as comparative measures. For a reconciliation of adjusted EBITDA to GAAP net income (loss), please refer to the tables at the end of this press release.
About Schrödinger
Schrödinger is transforming molecular discovery with its computational platform, which enables the discovery of novel, highly optimized molecules for drug development and materials design. Schrödinger’s software platform is built on more than 30 years of R&D investment and is licensed by biotechnology, pharmaceutical and industrial companies, and academic institutions around the world. Schrödinger also leverages the platform to advance a portfolio of collaborative and proprietary programs. To learn more, visit www.schrodinger.com, follow us on LinkedIn, or visit our blog, Extrapolations.com.
Operating Metrics
To supplement the financial measures presented in this press release and related conference call or webcast in accordance with generally accepted accounting principles in
Annual Contract Value (ACV). Schrödinger tracks the ACV for each customer. With respect to contracts that have a duration of one year or less, or contracts of more than one year in duration that are billed annually, ACV is defined as the contract value billed during the applicable period. For contracts with a duration of more than one year that are billed upfront, ACV in each period represents the total billed contract value divided by the term. ACV should be viewed independently of revenue and does not represent revenue calculated in accordance with GAAP on an annualized basis, as it is an operating metric that can be impacted by contract execution start and end dates and renewal rates. ACV is not intended to be a replacement for, or forecast of, revenue.
ACV by Cohorts. Schrödinger tracks ACV by certain industries and customer cohorts. These cohorts include contribution, which consists of customers from which we derive contribution revenue. We present this ACV separately because it relates to grant agreements accounted for as non-exchange contributions, rather than commercial software contracts. The operating metrics for the cohorts are not prepared in accordance with GAAP and do not correspond to the company’s reportable segments or the allocation of costs for GAAP purposes. These metrics allow management to better understand differences in sales cycles, contract duration, deployment models, renewal behavior, and expansion opportunities among customer and industry groups, supplementing but not replacing Schrödinger’s GAAP results.
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 including, but not limited to those statements regarding Schrödinger’s expectations about the speed and capacity of its computational platform, its financial outlook for the fiscal year ending December 31, 2026, and second quarter ending June 30, 2026, its plans to continue to invest in research and its strategic plans to accelerate the growth of its software licensing business and advance its collaborative and proprietary drug discovery programs, the long-term potential of its business, its ability to improve and advance the science underlying its platform, the initiation, timing, progress, and results of its proprietary drug discovery programs and product candidates and the drug discovery programs and product candidates of its collaborators, the clinical potential and favorable properties of SGR-1505 and SGR-3515, its MALT1 and Wee1/Myt1 inhibitors, its plans to explore strategic opportunities for the continued clinical development of SGR-1505 and SGR-3515, potential partnering and other business development activities for its programs, the clinical potential and favorable properties of its collaborators’ product candidates, expectations relating to the potential of, and the timing of release of, Bunsen, its agentic AI co-scientist, the ability for the company to realize potential benefits from its collaborative programs, including the amount and timing of additional milestones, if any, as well as expectations related to the use of its cash, cash equivalents and marketable securities. Statements including words such as “aim,” “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “goal,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and statements in the future tense are forward-looking statements. These forward-looking statements reflect Schrödinger’s current views about its plans, intentions, expectations, strategies and prospects, which are based on the information currently available to the company and on assumptions the company has made. Actual results may differ materially from those described in these forward-looking statements and are subject to a variety of assumptions, uncertainties, risks and important factors that are beyond Schrödinger’s control, including the demand for its software platform, its ability to further develop its computational platform, its reliance upon third-party providers of cloud-based infrastructure to host its software solutions, its ability to transition customers to hosted software deployments, factors adversely affecting the life sciences industry, fluctuations in the value of the
Condensed Consolidated Statements of Operations (Unaudited) (in thousands, except for share and per share amounts) |
|||||||
|
Three Months Ended
|
||||||
|
|
2026 |
|
|
|
2025 |
|
Revenues: |
|
|
|
||||
Software products and services |
$ |
35,560 |
|
|
$ |
44,972 |
|
Drug discovery |
|
22,879 |
|
|
|
10,236 |
|
Contribution |
|
148 |
|
|
|
4,343 |
|
Total revenues |
|
58,587 |
|
|
|
59,551 |
|
Cost of revenues: |
|
|
|
||||
Software products and services |
|
10,863 |
|
|
|
9,112 |
|
Drug discovery |
|
16,310 |
|
|
|
14,452 |
|
Contribution |
|
1,867 |
|
|
|
4,863 |
|
Total cost of revenues |
|
29,040 |
|
|
|
28,427 |
|
Gross profit |
|
29,547 |
|
|
|
31,124 |
|
Operating expenses: |
|
|
|
||||
Research and development |
|
43,824 |
|
|
|
45,844 |
|
Sales and marketing |
|
11,603 |
|
|
|
10,367 |
|
General and administrative |
|
22,914 |
|
|
|
25,802 |
|
Total operating expenses |
|
78,341 |
|
|
|
82,013 |
|
Loss from operations |
|
(48,794 |
) |
|
|
(50,889 |
) |
Other (expense) income: |
|
|
|
||||
Change in fair value of equity investments |
|
(13,487 |
) |
|
|
(13,095 |
) |
Other income |
|
2,663 |
|
|
|
4,204 |
|
Total other expense |
|
(10,824 |
) |
|
|
(8,891 |
) |
Loss before income taxes |
|
(59,618 |
) |
|
|
(59,780 |
) |
Income tax expense |
|
408 |
|
|
|
28 |
|
Net loss |
$ |
(60,026 |
) |
|
$ |
(59,808 |
) |
Net loss per share of common and limited common stockholders, basic and diluted: |
$ |
(0.81 |
) |
|
$ |
(0.82 |
) |
Weighted average shares used to compute net loss per share of common and limited common stockholders, basic and diluted: |
|
73,989,137 |
|
|
|
73,057,916 |
|
Condensed Consolidated Balance Sheets (Unaudited) (in thousands, except for share and per share amounts) |
|||||||
Assets |
March 31, 2026 |
|
December 31, 2025 |
||||
Current assets: |
|
|
|
||||
Cash and cash equivalents |
$ |
260,255 |
|
|
$ |
230,517 |
|
Restricted cash |
|
7,464 |
|
|
|
6,868 |
|
Marketable securities |
|
138,704 |
|
|
|
164,947 |
|
Accounts receivable, net of allowance for doubtful accounts of |
|
27,253 |
|
|
|
83,041 |
|
Unbilled and other receivables, net of allowance for unbilled receivables of |
|
20,930 |
|
|
|
21,352 |
|
Prepaid expenses |
|
9,353 |
|
|
|
12,540 |
|
Total current assets |
|
463,959 |
|
|
|
519,265 |
|
Property and equipment, net |
|
20,447 |
|
|
|
19,456 |
|
Equity investments |
|
39,826 |
|
|
|
73,647 |
|
Goodwill |
|
4,791 |
|
|
|
4,791 |
|
Right of use assets - operating leases |
|
100,198 |
|
|
|
102,736 |
|
Other assets |
|
4,966 |
|
|
|
6,265 |
|
Total assets |
$ |
634,187 |
|
|
$ |
726,160 |
|
Liabilities and Stockholders' Equity: |
|
|
|
||||
Current liabilities: |
|
|
|
||||
Accounts payable |
$ |
11,945 |
|
|
$ |
11,452 |
|
Accrued payroll, taxes, and benefits |
|
24,776 |
|
|
|
39,264 |
|
Deferred revenue |
|
103,111 |
|
|
|
112,853 |
|
Lease liabilities - operating leases |
|
16,013 |
|
|
|
16,412 |
|
Other accrued liabilities |
|
13,697 |
|
|
|
9,155 |
|
Total current liabilities |
|
169,542 |
|
|
|
189,136 |
|
Deferred revenue, long-term |
|
59,019 |
|
|
|
78,877 |
|
Lease liabilities - operating leases, long-term |
|
90,943 |
|
|
|
92,816 |
|
Other liabilities, long-term |
|
1,135 |
|
|
|
1,278 |
|
Total liabilities |
|
320,639 |
|
|
|
362,107 |
|
Stockholders' equity: |
|
|
|
||||
Preferred stock, |
|
— |
|
|
|
— |
|
Common stock, |
|
654 |
|
|
|
645 |
|
Limited common stock, |
|
92 |
|
|
|
92 |
|
Additional paid-in capital |
|
1,001,662 |
|
|
|
992,015 |
|
Accumulated deficit |
|
(688,832 |
) |
|
|
(628,806 |
) |
Accumulated other comprehensive (loss) income |
|
(28 |
) |
|
|
107 |
|
Total stockholders' equity |
|
313,548 |
|
|
|
364,053 |
|
Total liabilities and stockholders' equity |
$ |
634,187 |
|
|
$ |
726,160 |
|
Condensed Consolidated Statements of Cash Flows (Unaudited) (in thousands) |
|||||||
|
Three Months Ended March 31, |
||||||
|
|
2026 |
|
|
|
2025 |
|
Cash flows from operating activities: |
|
|
|
||||
Net loss |
$ |
(60,026 |
) |
|
$ |
(59,808 |
) |
Adjustments to reconcile net loss to net cash (used in) provided by operating activities: |
|
|
|
||||
Change in fair value of equity investments |
|
13,487 |
|
|
|
13,095 |
|
Depreciation and amortization |
|
1,476 |
|
|
|
1,589 |
|
Stock-based compensation |
|
9,073 |
|
|
|
11,574 |
|
Noncash investment accretion |
|
(664 |
) |
|
|
(861 |
) |
Loss on disposal of property and equipment |
|
11 |
|
|
|
— |
|
Decrease (increase) in assets: |
|
|
|
||||
Accounts receivable, net |
|
55,788 |
|
|
|
215,345 |
|
Unbilled and other receivables |
|
422 |
|
|
|
(6,332 |
) |
Reduction in the carrying amount of right of use assets - operating leases |
|
2,538 |
|
|
|
2,222 |
|
Prepaid expenses and other assets |
|
4,486 |
|
|
|
(788 |
) |
Increase (decrease) in liabilities: |
|
|
|
||||
Accounts payable |
|
455 |
|
|
|
1,344 |
|
Accrued payroll, taxes, and benefits |
|
(14,488 |
) |
|
|
(20,616 |
) |
Deferred revenue |
|
(29,600 |
) |
|
|
(10,804 |
) |
Lease liabilities - operating leases |
|
(2,272 |
) |
|
|
(1,669 |
) |
Other accrued liabilities |
|
4,480 |
|
|
|
(228 |
) |
Net cash (used in) provided by operating activities |
|
(14,834 |
) |
|
|
144,063 |
|
Cash flows from investing activities: |
|
|
|
||||
Purchases of property and equipment |
|
(2,507 |
) |
|
|
(596 |
) |
Proceeds from disposition and sale of equity investments, net |
|
20,334 |
|
|
|
— |
|
Purchases of marketable securities |
|
(34,055 |
) |
|
|
(27,556 |
) |
Proceeds from maturity of marketable securities |
|
60,827 |
|
|
|
58,784 |
|
Net cash provided by investing activities |
|
44,599 |
|
|
|
30,632 |
|
Cash flows from financing activities: |
|
|
|
||||
Proceeds from issuances of common stock upon stock option exercises |
|
583 |
|
|
|
423 |
|
Principal payments on finance leases |
|
(14 |
) |
|
|
(14 |
) |
Net cash provided by financing activities |
|
569 |
|
|
|
409 |
|
Net increase in cash and cash equivalents and restricted cash |
|
30,334 |
|
|
|
175,104 |
|
Cash and cash equivalents and restricted cash, beginning of period |
|
237,385 |
|
|
|
162,657 |
|
Cash and cash equivalents and restricted cash, end of period |
$ |
267,719 |
|
|
$ |
337,761 |
|
|
|
|
|
||||
Supplemental disclosure of cash flow and noncash information |
|
|
|
||||
Cash paid for income taxes |
$ |
266 |
|
|
$ |
139 |
|
Supplemental disclosure of non-cash investing and financing activities |
|
|
|
||||
Purchases of property and equipment in accounts payable |
|
78 |
|
|
|
13 |
|
Purchases of property and equipment in accrued liabilities |
|
— |
|
|
|
25 |
|
Reconciliation of GAAP Net Loss to Adjusted EBITDA (Unaudited) (in thousands) |
|||||||
|
Three Months Ended |
||||||
March 31, |
|||||||
|
|
2026 |
|
|
|
2025 |
|
Net loss (GAAP) |
$ |
(60,026 |
) |
|
$ |
(59,808 |
) |
Change in fair value of equity investments |
|
13,487 |
|
|
|
13,095 |
|
Other income |
|
(2,663 |
) |
|
|
(4,204 |
) |
Income tax expense |
|
408 |
|
|
|
28 |
|
Depreciation and amortization |
|
1,476 |
|
|
|
1,589 |
|
Stock-based compensation |
|
9,073 |
|
|
|
11,574 |
|
Reorganization expense (a) |
|
589 |
|
|
|
— |
|
Litigation and settlement expense (b) |
|
— |
|
|
|
390 |
|
Adjusted EBITDA |
$ |
(37,656 |
) |
|
$ |
(37,336 |
) |
| (a) | Represents costs in connection with restructuring, consisting of severance payments, employee benefits, and related costs. |
(b) |
Represents costs related to a derivative action settlement which we do not consider to be representative of our underlying operating performance. |
View source version on businesswire.com: https://www.businesswire.com/news/home/20260505334998/en/
Jaren Madden (Investors and Media)
Schrödinger, Inc.
jaren.madden@schrodinger.com
617-286-6264
Matthew Luchini (Investors)
Schrödinger, Inc.
matthew.luchini@schrodinger.com
917-719-0636
Source: Schrödinger