Vanguard Portfolio Management (SDGR) holds 3.91M shares, 6.04% stake

Rhea-AI Filing Summary

Vanguard Portfolio Management reports beneficial ownership of 3,911,087 shares of Schrodinger Inc. The filing shows 3,911,087 shares (representing 6.04% of the class) as of 03/31/2026. Vanguard Portfolio Management discloses sole voting power for 48,890 shares and sole dispositive power for 3,911,087 shares. The filing states these holdings include securities held by Vanguard funds and other client accounts for which Vanguard Portfolio Management or its affiliates exercise dispositive power.

Insights

Institutional Ownership Analyst

Vanguard holds a >5% stake in Schrodinger, reported as passive beneficial ownership.

Vanguard Portfolio Management reports ownership of 3,911,087 shares, equal to 6.04% of the class as of 03/31/2026. The filing is a Schedule 13G disclosure that typically reflects passive institutional positions rather than active control.

Cash‑flow treatment and disposition plans are not specified in the excerpt; subsequent filings would show any changes in voting or disposition intent.

Proxy and Governance Specialist

Voting and dispositive splits indicate limited voting control relative to economic ownership.

The filing lists sole voting power of 48,890 shares versus sole dispositive power of 3,911,087 shares, which suggests Vanguard exercises disposal authority broadly while voting power is concentrated on a smaller subset.

Disclosure notes that holdings include Vanguard funds and managed accounts; any governance influence depends on how those accounts' voting policies align with Vanguard Portfolio Management.

Key Figures

Shares beneficially owned: 3,911,087 shares Percent of class: 6.04% Sole voting power: 48,890 shares +2 more

5 metrics

Shares beneficially owned 3,911,087 shares Ownership reported as of 03/31/2026

Percent of class 6.04% Percent of Schrodinger common stock reported

Sole voting power 48,890 shares Number of shares Vanguard has sole voting power over

Sole dispositive power 3,911,087 shares Number of shares Vanguard has sole dispositive power over

Filing signatory date 04/29/2026 Signature date by Head of Global Fund Administration

Key Terms

Schedule 13G, beneficially owned, sole dispositive power, sole voting power, +1 more

5 terms

Schedule 13G regulatory

"This filing is a Schedule 13G disclosure of beneficial ownership"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

beneficially owned financial

"Amount beneficially owned: 3911087"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

sole dispositive power regulatory

"Sole power to dispose or to direct the disposition of: 3911087"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

sole voting power regulatory

"Sole power to vote or to direct the vote: 48890"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

Investment Company Act of 1940 regulatory

"investment company registered under the Investment Company Act of 1940"

A U.S. federal law that sets the rulebook for pooled investment vehicles such as mutual funds, exchange-traded funds and similar money managers, requiring them to register with regulators, disclose holdings and fees, limit conflicts of interest, and follow governance standards. It matters to investors because these protections and transparency rules act like a referee and scoreboard, helping people compare funds, trust that managers follow fair practices, and spot hidden costs or risks.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

Schrodinger Inc/United States

(Name of Issuer)

Common Stock

(Title of Class of Securities)

80810D103

(CUSIP Number)

03/31/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 80810D103

1

Names of Reporting Persons

Vanguard Portfolio Management

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 48,890.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 3,911,087.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

3,911,087.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.04 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by Vanguard Portfolio Management LLC and the following affiliates of Vanguard Portfolio Management LLC or business divisions of such affiliates: Vanguard Fiduciary Trust Company and Vanguard Global Advisers, LLC. This Schedule 13G includes securities held by Vanguard funds, or sleeves thereof, over which Vanguard Portfolio Management LLC exercises dispositive power, in addition to securities held by clients over which the affiliates or business divisions of such affiliates indicated above exercise dispositive and/or voting power. This Schedule 13G does not include securities, if any, beneficially owned by other subsidiaries or affiliates of Vanguard Portfolio Management LLC, or business divisions of such subsidiaries whose ownership of securities is disaggregated from that of the reporting business unit in accordance with such release.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Schrodinger Inc/United States
(b)	Address of issuer's principal executive offices: 120 West 45th Street, 17th Floor, New York, NY, 10036
Item 2.
(a)	Name of person filing: Vanguard Portfolio Management
(b)	Address or principal business office or, if none, residence: 100 Vanguard Blvd,, Malvern, PA, 19355
(c)	Citizenship: PA
(d)	Title of class of securities: Common Stock
(e)	CUSIP Number(s): 80810D103
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 3911087
(b)	Percent of class: 6.04 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 48890
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 3911087
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Vanguard Portfolio Management, including investment companies registered under the Investment Company Act of 1940 and other managed accounts, have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities reported herein.No one other person's interest in the securities reported herein is more than 5%.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Vanguard Portfolio Management

Signature:	Ashley Grim
Name/Title:	Head of Global Fund Administration
Date:	04/29/2026

FAQ

How many Schrodinger (SDGR) shares does Vanguard Portfolio Management report owning?

Vanguard Portfolio Management reports beneficial ownership of 3,911,087 shares, representing 6.04% of Schrodinger's common stock as of 03/31/2026. The filing is a Schedule 13G disclosure by an institutional investor.

What voting power does Vanguard Portfolio Management have in SDGR?

The filing shows Vanguard has sole voting power for 48,890 shares and no shared voting power. Dispositive power is held for 3,911,087 shares, per the Schedule 13G statements.

Does Vanguard hold these shares on behalf of clients or funds?

Yes. The filing states these holdings include securities held by Vanguard funds and managed accounts over which Vanguard Portfolio Management or affiliates exercise dispositive power, as described in the attached statement.

Is this Schedule 13G filing indicative of activist intentions by Vanguard?

This Schedule 13G reports passive beneficial ownership of 6.04%. The filing language describes managed funds and dispositive authority; it does not state activist intentions or plans for changing control.

What date is the ownership figure based on in the filing?

The ownership amounts are reported as of 03/31/2026, with the Schedule 13G signed on 04/29/2026 by Vanguard's Head of Global Fund Administration.