Welcome to our dedicated page for Sangamo Therapeutics news (Ticker: SGMO), a resource for investors and traders seeking the latest updates and insights on Sangamo Therapeutics stock.
Sangamo Therapeutics, Inc. (Nasdaq: SGMO) is a genomic medicine company whose news flow centers on clinical data, regulatory interactions, collaborations and financial updates across its neurology‑focused pipeline. Company announcements emphasize investigational programs in Fabry disease, chronic neuropathic pain and prion disease, along with progress in its zinc finger epigenetic regulation and AAV capsid platforms.
A major theme in recent SGMO news is the development of isaralgagene civaparvovec (ST‑920), a wholly owned investigational gene therapy for adults with Fabry disease. Press releases detail topline and updated results from the registrational Phase 1/2 STAAR study, including positive mean annualized estimated glomerular filtration rate (eGFR) slopes at 52 and 104 weeks, stability of cardiac endpoints, biomarker trends and quality‑of‑life measures. Regulatory milestones, such as FDA agreement to use eGFR slope as an endpoint for an accelerated approval pathway and acceptance of a rolling Biologics License Application (BLA) submission, are also key subjects.
Investors following SGMO news can also track developments in the Phase 1/2 STAND study of ST‑503 for intractable pain due to small fiber neuropathy, including FDA Fast Track Designation, site activation and recruitment updates. Additional releases describe preclinical and regulatory progress for ST‑506 in prion disease, as well as business development activities like the capsid license agreement with Eli Lilly and Company and other collaboration‑related revenues.
Quarterly earnings releases and conference call announcements provide context on Sangamo’s operating expenses, cash position and strategic focus on a neurology‑oriented genomic medicine business. For readers interested in SGMO, this news page aggregates these clinical, regulatory, partnership and financial disclosures in one place, making it easier to follow the company’s reported milestones over time.
Sangamo Therapeutics announced updated data from Phase 1/2 STAAR study of isaralgagene civaparvovec (ST-920) for Fabry disease. Key findings show sustained benefits with elevated α-Gal A activity maintained for nearly four years in the longest-treated patient. The study demonstrated positive mean eGFR slope in 23 patients with one-year follow-up, indicating improved kidney function.
All 18 patients initially on enzyme replacement therapy (ERT) have successfully discontinued and remain off treatment. The therapy showed a favorable safety profile with mostly grade 1-2 adverse events and no treatment discontinuations. Quality of life measures showed significant improvements, including physical and emotional aspects.
Following FDA alignment on Accelerated Approval Pathway, Sangamo expects to submit data in first half of 2025, with potential BLA submission in second half of 2025. The company is actively pursuing business development discussions for potential ST-920 collaboration.
Sangamo Therapeutics (SGMO) will regain full rights to its hemophilia A gene therapy program, giroctocogene fitelparvovec, following Pfizer's decision to terminate their collaboration agreement effective April 21, 2025. Despite the Phase 3 AFFINE trial meeting primary and secondary endpoints with positive results, Pfizer has chosen not to proceed with Biologics License Application (BLA) and Marketing Authorisation Application (MAA) submissions.
The therapy demonstrated potential as a treatment for adults with moderately severe to severe hemophilia A. Sangamo plans to explore all options to advance the program, including seeking a new collaboration partner. The company remains focused on its neurology genomic medicine pipeline and Fabry gene therapy program, with partnerships with Genentech and Astellas supporting these initiatives.
Sangamo Therapeutics (SGMO) and Astellas Pharma have entered into a license agreement for Sangamo's proprietary neurotropic AAV capsid, STAC-BBB, which has shown strong blood-brain barrier penetration capabilities in nonhuman primates. The agreement grants Astellas worldwide exclusive rights to use STAC-BBB for one target, with options for four additional neurological disease targets.
Sangamo will receive a $20 million upfront license fee and could earn up to $1.3 billion in additional target fees and milestone payments across all five potential targets, plus tiered mid-to-high single-digit royalties on potential net sales. Astellas will handle all research, development, manufacturing, and commercialization activities, while Sangamo will complete the technology transfer.
Sangamo Therapeutics (Nasdaq: SGMO) received FDA clearance for its IND application for ST-503, an epigenetic regulator targeting chronic neuropathic pain in idiopathic small fiber neuropathy (iSFN). The company plans to initiate a Phase 1/2 study in mid-2025 to evaluate this one-time intrathecal treatment. ST-503 uses AAV vector technology with zinc finger repressors to target the SCN9A gene, which controls Nav1.7 sodium channels important for pain signaling. The treatment addresses iSFN, affecting an estimated 43,000 U.S. patients, with broader peripheral neuropathies impacting nearly 40 million Americans. Preclinical research showed promising results in reducing pain hypersensitivity with no off-target effects.
Sangamo Therapeutics reported significant Q3 2024 developments, including FDA's agreement for Accelerated Approval pathway for its Fabry disease gene therapy, potentially advancing approval by three years. The company received $50 million in upfront fees from Genentech, with potential for $1.9 billion in additional milestone payments. Q3 financial results showed net income of $10.7 million ($0.04 per share), with revenues of $49.4 million. Cash position stands at $39.2 million, expected to fund operations into Q1 2025. Pfizer will present Phase 3 AFFINE trial data for Hemophilia A gene therapy at ASH, showing positive results in meeting primary endpoints.
Sangamo Therapeutics (Nasdaq: SGMO) has announced it will release its third quarter 2024 financial results after market close on Tuesday, November 12, 2024. The company will host a conference call at 4:30 p.m. Eastern on the same day to discuss financial results and provide business updates. Participants can register for the call through a provided link and are advised to join 10 minutes before the start. The webcast will be available on Sangamo's website in the Investors and Media section, with a replay accessible afterward.
Sangamo Therapeutics (SGMO) reported Q2 2024 results and recent business highlights:
Key developments:
- Announced global license agreement with Genentech for neurodegenerative disease therapies, potentially worth up to $1.9 billion plus royalties
- Reported positive Phase 3 results for Hemophilia A gene therapy developed with Pfizer
- Continued progress in Phase 1/2 Fabry disease gene therapy trial
- Advancing neurology-focused preclinical pipeline
Financial results:
- Q2 net loss: $36.1 million ($0.18 per share)
- Q2 revenue: $0.3 million
- Cash position: $27.8 million as of June 30, 2024
- Expects $50 million in near-term payments from Genentech deal
Sangamo believes its cash runway extends into Q1 2025 with the Genentech payments.
Sangamo Therapeutics (Nasdaq: SGMO) has entered a global license agreement with Genentech to develop intravenous genomic medicines for neurodegenerative diseases. The deal focuses on Sangamo's zinc finger repressors targeting the tau gene, important in Alzheimer's and tauopathies, and another undisclosed neurology target. Sangamo is also licensing its proprietary AAV capsid, STAC-BBB, which has shown strong blood-brain barrier penetration.
Key financial terms include:
- $50 million in near-term upfront fees and milestone payments
- Up to $1.9 billion in potential development and commercial milestones
- Tiered royalties on net sales
Sangamo will handle technology transfer and preclinical activities, while Genentech will lead clinical development, regulatory interactions, manufacturing, and global commercialization.
Sangamo Therapeutics (Nasdaq: SGMO), a genomic medicine company, has scheduled its second quarter 2024 financial results release for Tuesday, August 6, 2024, after market close. The company will host a conference call at 4:30 p.m. Eastern on the same day to review the results and provide business updates.
Participants can register and access the call using a provided link, with a recommendation to join 10 minutes early. The call will offer options to dial in or use a dial-out feature for instant phone connection. A live webcast will be available on the Sangamo website's Investors and Media section, with a replay accessible afterwards under Events.
Sangamo Therapeutics (SGMO) reported on Pfizer's announcement of positive topline results from the Phase 3 AFFINE trial evaluating giroctocogene fitelparvovec, a gene therapy for hemophilia A. The trial met its primary objective of non-inferiority and superiority in total annualized bleeding rate (ABR) compared to routine Factor VIII replacement. Key findings include:
- Significant ABR reduction (1.24 vs 4.73)
- 84% of participants maintained FVIII activity >5% at 15 months
- 98.3% reduction in mean treated ABR
- Generally well-tolerated safety profile
Sangamo is eligible for up to $220 million in milestone payments and 14-20% royalties if approved. The therapy aims to provide long-term bleed protection with a single infusion.