Silence Therapeutics Plc Stock Price, News & Analysis

Silence Therapeutics plc (NASDAQ: SLN) has announced a leadership change, appointing Craig Tooman as President and CEO, succeeding Mark Rothera, who steps down immediately. Rhonda Hellums takes over as CFO. Tooman brings over 30 years of experience, including previous roles at Vyome Therapeutics and Aratana Therapeutics. Iain Ross, Chairman, expressed confidence in Tooman’s ability to enhance the company's strategy and leverage positive clinical data from SLN360 to ensure long-term shareholder value.

Silence Therapeutics announced positive results from the phase 1 single-ascending dose study of SLN360, an investigational siRNA for lowering lipoprotein(a) (Lp(a)).

SLN360 demonstrated a significant reduction in Lp(a) by up to 98%, with reductions of up to 81% lasting for 150 days. The study involved 32 adults with high Lp(a) and showed no major safety concerns. Results will be presented at the American College of Cardiology Scientific Session on April 3, 2022.

Silence plans to initiate a phase 2 study in patients with stable atherosclerotic cardiovascular disease in the second half of 2022.

Silence Therapeutics, a leader in siRNA therapeutics, announced that a late-breaking clinical abstract on the SLN360 phase 1 study will be presented at the ACC Annual Scientific Session on April 3, 2022. This study focuses on healthy volunteers with high lipoprotein(a) levels. Topline data from this study is set to be reported this quarter. The principal investigator, Dr. Steven Nissen from the Cleveland Clinic, will present detailed results during the session, highlighting the study's significance in addressing cardiovascular risk.

Silence Therapeutics plc (Nasdaq: SLN) has announced that Dr. Marie Wikström Lindholm has been elected to the Board of Directors of the Oligonucleotide Therapeutics Society for a two-year term. This appointment underscores her significant contributions to the field of oligonucleotide therapeutics and is expected to enhance the company's reputation in scientific excellence. Dr. Lindholm has been with Silence since December 2017, playing a critical role in optimizing their proprietary mRNAi GOLD™ platform aimed at treating diseases with high unmet medical needs.

Silence Therapeutics (Nasdaq: SLN) announced its participation in the H.C. Wainwright BioConnect Virtual Conference scheduled for January 10-13, 2022. The company will feature in a fireside chat, with an on-demand presentation available from January 10 at 7:00 AM ET / 12:00 PM GMT via its Investors section on the Silence website. This engagement highlights Silence's commitment to addressing unmet medical needs through innovative siRNA therapeutics, including SLN360 for cardiovascular risk and SLN124 for rare hematological diseases.

Silence Therapeutics plc (Nasdaq: SLN) presented positive data from the SLN124 healthy volunteer study at the 2021 ASH Annual Meeting. The study showed durable reductions in serum iron and transferrin saturation, with a strong safety profile and long duration of action. SLN124 targets the TMPRSS6 gene and is in development for conditions like iron loading anemia, thalassemia, and myelodysplastic syndrome. Results indicated significant hepcidin modulation and favorable safety outcomes, propelling ongoing studies in diverse hematological diseases.

On December 1, 2021, Silence Therapeutics plc (Nasdaq: SLN) announced a significant investment from Deep Track Capital, totaling approximately $22 million in American Depositary Shares from existing shareholders. This investment is seen as a vote of confidence in Silence's promising pipeline, particularly its proprietary mRNAi GOLD™ platform. The company anticipates key data from its SLN360 program in early 2022, aiming to address cardiovascular risks associated with high lipoprotein(a). This marks Silence's first day of exclusive trading on Nasdaq and a continued expansion of its U.S. institutional shareholder base.

Silence Therapeutics, a leader in RNA interference therapeutics, has successfully transitioned its trading from AIM to the Nasdaq Global Market under the ticker symbol SLN as of November 30, 2021. This move aims to enhance investor access, particularly targeting U.S. institutional funds. The last trading day on AIM was November 29, 2021, and the company encourages shareholders to convert their Ordinary Shares into American Depositary Shares (ADSs) for Nasdaq trading. Silence continues to advance its mRNAi GOLD™ platform with ongoing collaborations and product candidates addressing significant medical needs.

Silence Therapeutics will present at the Jefferies London Healthcare Conference from November 16-18, 2021. The on-demand presentation will be available starting November 18 at 8:00am GMT / 3:00am ET via the company's website. Silence Therapeutics focuses on developing siRNA therapeutics targeting diseases with significant unmet medical needs. Their proprietary mRNAi GOLD™ platform aims to treat conditions like high lipoprotein(a) levels and iron-loading anemia. Archived webcasts will also be accessible post-conference.