Welcome to our dedicated page for Sensei Biotherapeutics news (Ticker: SNSE), a resource for investors and traders seeking the latest updates and insights on Sensei Biotherapeutics stock.
Sensei Biotherapeutics, Inc. develops clinical-stage cancer therapeutics focused on multi-node inhibition of oncogenic pathways. Its lead program, PIKTOR, is an investigational all-oral combination of serabelisib and sapanisertib designed to target PI3K-alpha and dual mTORC1/2 nodes in the PI3K/AKT/mTOR pathway for endometrial and breast cancer. The company also reports on solnerstotug, a V-domain Ig suppressor of T cell activation, or VISTA, inhibitor for advanced solid tumors.
Recurring company news includes oncology trial activity, clinical and regulatory disclosures, operating and financial results, governance updates, capital-structure matters, and Nasdaq inducement equity grants tied to employee compensation.
Sensei Biotherapeutics (Nasdaq: SNSE) announced on October 30, 2025 that its Board has decided to discontinue development of solnerstotug and has initiated a comprehensive strategic review to maximize shareholder value.
The company said it is evaluating options including asset sales, licensing, collaborations, a sale of the company, merger, business combination, or an orderly wind-down. Sensei expects a workforce reduction to preserve cash and will retain a small team to support the strategic process, regulatory and reporting obligations, and an orderly wind-down of the Phase 1/2 trial. No definitive timeline or assurance of a transaction was provided.
Sensei Biotherapeutics (Nasdaq: SNSE) reported Phase 1/2 dose-expansion results for solnerstotug at ESMO 2025 showing dose-dependent activity and tolerability in PD-(L)1 resistant “hot” tumors.
Key data: 6-month PFS 50% at 15 mg/kg in PD-(L)1 resistant patients versus overall 6-month PFS of 37% across prior PD-(L)1 progressors; six clinical responses occurred at 15 mg/kg including one durable complete response (MCC, 54+ weeks). Safety: six Grade 1 CRS events (all at 15 mg/kg) and no new safety signals (Phase 1 n=98, dose expansion n=64).
Sensei plans Phase 2 trials in 2L NSCLC and PD-(L)1 resistant MCC in 2026, subject to FDA feedback and financing. Investor webcast Oct 20, 2025 at 8:00 AM ET.
Sensei Biotherapeutics (NASDAQ:SNSE) announced a virtual Key Opinion Leader (KOL) event scheduled for October 20, 2025, at 8:00 AM ET. The event will feature Dr. Kyriakos Papadopoulos, Co-Director of Clinical Research at START San Antonio, who will discuss immunotherapy-resistant solid tumors.
The presentation will include updates on Phase 2 study plans and complete data from the Phase 1/2 dose expansion cohort for Solnerstotug (formerly SNS-101), their conditionally active monoclonal antibody targeting VISTA in PD-(L)1 resistant tumors. The data will also be presented at ESMO on October 17th.
Sensei Biotherapeutics (NASDAQ:SNSE), a clinical stage biotech company developing next-generation cancer therapeutics, announced its participation in the upcoming H.C. Wainwright 27th Annual Global Investment Conference.
CEO John Celebi will conduct one-on-one investor meetings on September 8, 2025. The company's on-demand corporate presentation will be available starting September 5, 2025, at 7:00 a.m. ET. Investors can access the webcast replay in the Investors section of Sensei's website for approximately 90 days after the event.
Sensei Biotherapeutics (NASDAQ:SNSE) reported Q2 2025 financial results and provided updates on its clinical programs. The company's lead candidate solnerstotug showed promising results in its Phase 1/2 trial, demonstrating a favorable safety profile in combination with cemiplimab. The study included 64 patients in the dose expansion cohort, with 41 patients having prior PD-(L)1 resistance.
Financial highlights include cash position of $28.6 million as of June 30, 2025, expected to fund operations into Q2 2026. The company reported a reduced net loss of $4.9 million compared to $7.1 million in Q2 2024, with decreased R&D expenses of $2.5 million and G&A expenses of $2.7 million.
Full data from the Phase 1/2 dose expansion cohort is expected by year-end 2025, with upcoming presentation at ESMO Congress 2025 in October.
Sensei Biotherapeutics (NASDAQ: SNSE) has announced an upcoming presentation of clinical data at the ESMO Congress 2025 in Berlin, Germany. The presentation will focus on results from the Phase 1 dose expansion cohort studying solnerstotug, both as a monotherapy and in combination with Regeneron's PD-1 inhibitor Libtayo® (cemiplimab).
The study specifically examines patients with advanced solid tumors resistant to prior PD-(L)1 therapy. Dr. Kyriakos Papadopoulos from START, San Antonio will present the findings on October 17, 2025 during a mini oral session.
Sensei Biotherapeutics (Nasdaq: SNSE), a clinical stage biotechnology company specializing in next-generation cancer therapeutics, has announced its participation in an upcoming industry event. John Celebi, President and CEO, will be a panelist in the New Radiotherapy and Targeted Therapy Approaches discussion at the Canaccord Genuity Horizons in Oncology Virtual Conference. The panel is scheduled for Monday, April 7 at 2:00 p.m. ET.
Sensei Biotherapeutics (NASDAQ: SNSE) reported its full year 2024 financial results and clinical progress for solnerstotug, their conditionally active antibody targeting VISTA. Key clinical highlights include:
In the Phase 1/2 dose expansion study, among 21 evaluable PD-(L)1 resistant tumor patients, the combination therapy showed 14% overall response rate (3x higher than historical rates) and 62% disease control rate. The study achieved target enrollment of 60 patients, with full expansion data expected by year-end 2025.
Financial results show:
- Cash position: $41.3M as of December 31, 2024
- R&D expenses: $18.6M (vs $18.3M in 2023)
- G&A expenses: $13.0M (vs $18.8M in 2023)
- Net loss: $30.2M (vs $34.1M in 2023)
The company expects its current cash runway to extend into Q2 2026.