Spruce Biosciences Announces Presentation of MPS IIIB Natural History Data at the 55th Child Neurology Society Annual Meeting

Spruce Biosciences (SPRB) will present MPS IIIB natural history data at the Child Neurology Society Annual Meeting on October 15, 2026.

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SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)-- Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that data from Study 250-902 (NCT03227042), a prospective, multicenter, multinational, noninterventional, longitudinal natural history study designed to characterize disease progression in pediatric participants with severe, non-attenuated Sanfilippo Syndrome Type B (MPS IIIB) will be presented at the 55^th Child Neurology Society (CNS) Annual Meeting, taking place October 14–17, 2026, in Montréal, Québec, Canada. The poster will be available on the Spruce Biosciences website following the presentation.

CNS Annual Meeting Poster Presentation Details

Title: In-depth analyses of cognition, motor, communication, and adaptive natural history disease course in participants with MPS IIIB
Session Type: Poster Presentation – Neurodevelopmental Disorders
Poster Number: 235
Presentation Date & Time: October 15, 2026, 12:30 p.m. – 1:45 p.m. EDT and 5:30 p.m. – 7:30 p.m. EDT
Presenter: Ilyas Okur, M.D., Professor of Pediatrics and Pediatric Metabolism Specialist, Gazi University Faculty of Medicine, Ankara, Türkiye
Authors: Ilyas Okur, M.D.; Fatih Ezgu, M.D.; Yin-Hsiu Chien, M.D., Ph.D.; Cara O’Neill, M.D., FAAP; Roberto Giugliani, M.D., Ph.D.; Can Ficicioglu, M.D., Ph.D.; Igor Nestrasil, M.D., Ph.D.; Irene J. Chang, M.D.; Elizabeth R. Jalazo, M.D.; Martha Solano, M.D.; Saba Sile, M.D.; Richard Kim, M.D.; Kirk Ways, M.D., Ph.D.; and Nicole Muschol, M.D.

About Spruce Biosciences

Spruce Biosciences is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need. Spruce’s lead product candidate, tralesinidase alfa enzyme replacement therapy (TA-ERT), is in late-stage development for the treatment of MPS IIIB, a devastating pediatric neurodegenerative disorder for which there are no FDA-approved therapies. TA-ERT has received Breakthrough Therapy Designation, Rare Pediatric Disease Designation, Fast Track Designation and Orphan Drug Designation from the FDA, as well as Orphan Drug Designation in the European Union. To learn more, visit www.sprucebio.com and follow us on X, LinkedIn, Facebook and YouTube.

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding, among other things, statements regarding the planned presentation of natural history data at the 55th Child Neurology Society Annual Meeting and the development of TA-ERT. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Words such as “plan,” “will,” “believe,” “could,” “expect,” “on track,” “potential” and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon Spruce’s current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with Spruce’s business in general, the impact of geopolitical and macroeconomic events, and the other risks described in Spruce’s filings with the U.S. Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management’s assumptions and estimates as of such date. Spruce undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.

View source version on businesswire.com: https://www.businesswire.com/news/home/20261008501925/en/

Media

Heidi Chokeir
Inizio Evoke Comms
Heidi.Chokeir@inizioevoke.com
media@sprucebio.com

Investors

Monique Kosse
Gilmartin Group
Monique@GilmartinIR.com
investors@sprucebio.com

Source: Spruce Biosciences, Inc.

Key Terms

natural history study medical

A natural history study is an observational research project that follows people with a specific disease over time to document how the condition develops, what symptoms appear, and typical outcomes without testing a new treatment. Investors care because these studies create a factual map of the disease—like a road atlas for drug developers—helping companies design efficient clinical trials, choose meaningful goals for approval, estimate how many patients could benefit, and reduce the guesswork and risk around a drug’s path to market.

noninterventional medical

A noninterventional study is a type of medical study where researchers observe what happens when patients receive routine care, without assigning specific treatments or changing doctors’ decisions—think of watching a cooking show rather than altering the recipe. For investors, these studies matter because they are usually quicker, less costly and reflect real-world use, but they provide weaker proof about cause and effect than controlled trials, affecting risk, regulatory expectations and market timing.

longitudinal medical

Longitudinal describes observations or data collected from the same subjects or entities repeatedly over time, tracking how things change rather than a single snapshot. For investors it matters because longitudinal information reveals trends, persistence, and potential cause-and-effect (for example in sales, safety outcomes, or earnings), helping distinguish short-term noise from meaningful long-term shifts—like watching a plant grow rather than looking at a single photo.