Welcome to our dedicated page for Scholar Rock Holding news (Ticker: SRRK), a resource for investors and traders seeking the latest updates and insights on Scholar Rock Holding stock.
Scholar Rock Holding Corporation (SRRK) is a clinical-stage biopharmaceutical company pioneering targeted therapies that modulate growth factor activation in serious diseases. This page serves as the definitive source for official updates, including clinical trial progress, regulatory milestones, and strategic partnerships.
Investors and researchers will find curated news spanning SRRK's neuromuscular, oncology, and metabolic disorder pipelines. Content includes earnings reports, scientific presentations, and manufacturing updates—all essential for tracking the company's novel niche modulator platform.
Key focus areas include apitegromab in spinal muscular atrophy, obesity therapeutics, and fibrosis interventions. Updates are organized chronologically with clear sourcing to maintain transparency. Bookmark this page for streamlined access to SRRK's advancements in precision biologics.
Scholar Rock (NASDAQ: SRRK) announced new preclinical data for SRK-439, a myostatin inhibitor, showing promising results in lean mass preservation and fat mass rebound attenuation following GLP-1 receptor agonist (GLP-1 RA) withdrawal.
The data were presented at the American Diabetes Association’s 84th Scientific Sessions. The company also revealed that the first participants were dosed in the Phase 2 EMBRAZE trial to assess the safety and efficacy of apitegromab, another myostatin inhibitor, in individuals with obesity.
Preclinical studies on a diet-induced obesity mouse model showed that SRK-439 administration preserved lean mass and reduced fat mass rebound compared to a control group. Key findings include higher relative lean mass (65.8%) and lower relative fat mass (18.0%) in mice treated with SRK-439 at the end of the withdrawal period.
These results support the potential of SRK-439 for healthier weight management and long-term metabolic benefits, which could be transformative for obesity treatment.
Scholar Rock (NASDAQ: SRRK), a late-stage biopharmaceutical company, announced the grant of inducement equity awards to five new employees under Nasdaq Listing Rule 5635(c)(4). These awards consist of 96,700 shares of common stock, including 55,258 inducement stock options and 41,442 restricted stock units. The exercise price for the stock options is set at $9.63 per share, equal to the closing price on June 10, 2024. The stock options will vest 25% after one year and the remaining 75% in 12 quarterly installments. Restricted stock units will vest annually in four equal installments. All awards are part of the 2022 Inducement Equity Plan, designed to attract new talent.
Scholar Rock (NASDAQ: SRRK) presented new data from its Phase 1 DRAGON trial of SRK-181, a selective inhibitor of latent TGFβ1 activation, in combination with pembrolizumab at the ASCO 2024 Annual Meeting. The study showed promising objective response rates (ORR) in various tumor types for patients resistant to anti-PD-(L)1 therapies. Clear cell renal cell carcinoma (ccRCC) patients exhibited a doubling of the ORR, suggesting a potential patient selection strategy. SRK-181 was generally well tolerated, with no Grade 5 treatment-related adverse events. These findings bolster confidence in SRK-181's ability to overcome immune checkpoint inhibitor-associated resistance. Scholar Rock plans to discuss these results further with the FDA.
Scholar Rock (NASDAQ: SRRK) will present new data from the Phase 1 DRAGON trial of SRK-181 in combination with pembrolizumab at the ASCO Annual Meeting, May 31 – June 4 in Chicago. The trial demonstrated encouraging responses and tolerability in patients with advanced solid tumors, including ccRCC, HNSCC, melanoma, and UC. It also showed that the SRK-181 + pembrolizumab combination improved the proinflammatory microenvironment. A positive correlation between CD8+ T cell infiltration and response rate was observed in ccRCC patients. An oral presentation of the data is scheduled for June 3 at 1:50 p.m. CDT, followed by a conference call on June 4 at 8 a.m. EDT.
Scholar Rock (NASDAQ: SRRK) has initiated the Phase 2 EMBRAZE trial to evaluate the efficacy and safety of apitegromab in preserving lean muscle mass in obese individuals on GLP-1 receptor agonist therapy. The trial involves 100 participants and will last 24 weeks, with primary results expected by mid-2025.
New preclinical data revealed SRK-439's superior performance over anti-ActRII antibodies in preserving lean mass in diet-induced obesity mice. SRK-439 showed significant lean mass preservation at lower doses compared to anti-ActRII, indicating its potential as a best-in-class treatment for obesity-related muscle mass preservation.
The company shared these findings at an Investor Event, emphasizing the advantage of selective latent myostatin inhibition. Future data presentations and an anticipated IND filing for SRK-439 in 2025 are planned.
Scholar Rock (NASDAQ: SRRK), a late-stage biopharmaceutical company, announced its participation in several upcoming investor conferences in June. The events include: UBS Obesity Therapeutics Day on May 23 at 9:00 a.m. ET, Jefferies Global Healthcare Conference on June 6 at 2:00 p.m. ET in New York City, and the 45th Annual Goldman Sachs Global Healthcare Conference on June 13 at 9:20 a.m. ET in Miami, Florida. These conferences will feature various presentations and virtual chats, with live webcasts available on Scholar Rock's website and archived for replay for approximately 90 days.
Scholar Rock (NASDAQ: SRRK), a late-stage biopharmaceutical company, has announced inducement equity awards under Nasdaq Listing Rule 5635(c)(4).
The awards cover an aggregate of 102,150 shares, including 58,370 stock options and 43,780 restricted stock units. These grants are part of Scholar Rock's 2022 Inducement Equity Plan, aimed at attracting new talent.
The stock options have an exercise price of $13.64, with vesting schedules based on employee service. This news is part of Scholar Rock's ongoing efforts to advance treatments for serious diseases.
Scholar Rock (NASDAQ: SRRK) will host an Investor Day on May 22, 2024, starting at 8:30 a.m. ET in New York City. The event will feature presentations from the executive management team on their myostatin inhibition programs targeting spinal muscular atrophy (SMA) and obesity. Renowned experts Dr. Ania Jastreboff of Yale School of Medicine and Dr. Diana Castro of the Neurology & Neuromuscular Care Center will also provide insights. Participants can access a live webcast and slide presentation via Scholar Rock's website, with a replay available for 90 days.
Scholar Rock, a late-stage biopharmaceutical company focused on innovative treatments for SMA and cardiometabolic disorders, reported Q1 2024 financial results. They are on track to report Phase 3 SAPPHIRE trial data in Q4 2024. Initiating Phase 2 trial for apitegromab in obesity. Strong financial position with $238 million in cash. Positive clinical data presentations for SRK-181 and SRK-439.
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