Surrozen Inc Stock Price, News & Analysis

Surrozen, Inc. (Nasdaq: SRZN), a biotech firm focusing on Wnt pathway therapeutics, appointed Eric Bjerkholt to its Board of Directors. Bjerkholt, who has extensive experience in biotechnology, is currently the CFO of Chinook Therapeutics and previously served as CFO of Aimmune Therapeutics, leading its $2.6 billion acquisition by Nestlé Health Science. Surrozen's Board now consists of nine members with diverse expertise in the field. CEO Craig Parker expressed confidence in Bjerkholt's insights and strategic acumen, especially as the company aims to develop technologies addressing significant medical needs.

Surrozen, Inc. (SRZN) announced key developments in its clinical pipeline, enrolling the first patient in the Phase 1a trial of SZN-043 for chronic liver disease, with data expected by the end of 2023. The company plans to initiate a Phase 1b trial for severe alcoholic hepatitis in 2024, anticipating proof-of-concept data in the latter half of 2024. SZN-1326's Phase 1a trial in healthy volunteers is set to resume by mid-2023, with potential ulcerative colitis data expected in 2024. Surrozen's restructuring initiatives have extended its cash runway into late 2024. The company's financial position includes approximately $75.8 million in cash, with R&D expenses reduced by 15% in 2023.

Surrozen, Inc. (Nasdaq: SRZN) will report its Q4 and full year 2022 financial results on March 22, 2023, after the U.S. markets close. The company will also provide a corporate and pipeline progress update during a live audio webcast at 4:30 PM ET. Interested participants can access the webcast via the Investor website. Surrozen is a clinical-stage biotechnology firm focused on developing drug candidates that selectively modulate the Wnt pathway, targeting conditions like inflammatory bowel disease, severe liver issues, and eye diseases.

Surrozen, a clinical-stage biotechnology company, will present at the 41st Annual J.P. Morgan Healthcare Conference on January 12, 2023, at 7:30 a.m. Pacific time. The presentation will focus on their innovative therapies targeting the Wnt pathway for tissue repair and regeneration. A live audio webcast will be available on Surrozen's Investor Relations website. Surrozen aims to address diseases like inflammatory bowel disease and certain neurological disorders through its targeted therapies.

Surrozen, Inc. (Nasdaq: SRZN) reported Q3 2022 financial results, with cash reserves at $78.4 million, down from $92.7 million in Q2 2022. The net loss narrowed to $13.4 million from $14.0 million a year prior. Enrollment in the SZN-1326 Phase 1 trial was paused due to adverse liver events, while SZN-043 is ongoing with mild liver transaminase elevations observed. Surrozen partnered with Boehringer Ingelheim for SZN-413, receiving a $12.5 million upfront payment and potential future milestones of $586.5 million. Research expenses decreased to $8.6 million, while general administrative expenses rose to $5.0 million.

Surrozen, Inc. (Nasdaq: SRZN) presented preclinical data at the United European Gastroenterology Week that supports its drug candidates SZN-1326 and SZN-043 for treating ulcerative colitis and severe liver diseases, respectively. SZN-043 showed rapid hepatocyte proliferation and safety in non-clinical studies, while SZN-1326 improved epithelial healing and reduced collagen deposition. Both candidates exhibited no adverse effects in toxicology studies. The Phase 1 clinical trials for both candidates are ongoing, initiated in May and June 2022.

Surrozen has announced a significant collaboration with Boehringer Ingelheim to develop SZN-413, a bi-specific antibody aimed at treating retinal diseases. This agreement marks Surrozen's first strategic partnership and includes an upfront payment of $12.5 million, plus potential milestone payments of up to $586.5 million. SZN-413 utilizes Surrozen's SWAP™ technology to target Fzd4-mediated Wnt signaling, promoting retinal vessel regrowth and reducing vascular leakage. Boehringer will take on research and commercialization responsibilities following an initial joint research period.

Surrozen (Nasdaq: SRZN) announced promising results from recent studies published in Translational Vision Science and Technology. The research highlighted SZN-413, a bi-specific antibody targeting FZD4 and LRP5, as a potential novel treatment for diabetic retinopathy, a major cause of vision loss. SZN-413 was shown to effectively reduce retinal vascular leakage by approximately 80% and significantly diminished areas of pathologic neovascularization. This mechanism may address both retinal non-perfusion and leakage, indicating a potential breakthrough for retinal vascular diseases.