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Tenax Therapeutics to Host Virtual KOL Call to Discuss TNX-103 (Oral Levosimendan) for the Treatment of PH-HFpEF

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Tenax Therapeutics (NASDAQ: TENX) will host a virtual KOL call on November 13, 2025 at 4:30 p.m. ET to discuss the PH-HFpEF treatment landscape and the late-stage program for TNX-103 (oral levosimendan).

Panelists include Tenax management and KOLs Barry A. Borlaug, M.D., and Sanjiv J. Shah, M.D. The company is advancing TNX-103 in two registrational Phase 3 studies, LEVEL (North American enrollment ongoing) and LEVEL-2 (global study on track to initiate in 2025). The call will be available live and archived via the company investor relations webpage; dial-in numbers are provided for U.S. and international callers.

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News Market Reaction 1 Alert

-2.40% News Effect
-$776K Valuation Impact
$32M Market Cap
0.2x Rel. Volume

On the day this news was published, TENX declined 2.40%, reflecting a moderate negative market reaction. This price movement removed approximately $776K from the company's valuation, bringing the market cap to $32M at that time.

Data tracked by StockTitan Argus on the day of publication.

CHAPEL HILL, N.C., Nov. 06, 2025 (GLOBE NEWSWIRE) -- Tenax Therapeutics, Inc. (Nasdaq: TENX) (“Tenax Therapeutics” or the “Company”), a Phase 3, development-stage pharmaceutical company using clinical insights to develop novel cardiopulmonary therapies, today announced that the Company will host a conference call and webcast on Thursday, November 13, 2025, at 4:30 p.m. ET.

Members of the management team will be joined by the below recognized key opinion leaders in cardiovascular medicine to discuss the treatment landscape for pulmonary hypertension in heart failure with preserved ejection fraction (PH-HFpEF) and the ongoing late-stage development program for TNX-103 (oral levosimendan).

  • Barry A. Borlaug, M.D., Professor of Medicine, Department of Cardiovascular Medicine, and Professor of Cardiology, Mayo Clinic
  • Sanjiv J. Shah, M.D., Director of Research, Bluhm Cardiovascular Institute and Director, HFpEF Program, Northwestern University Feinberg School of Medicine

Tenax is advancing TNX-103 in patients with PH-HFpEF in two registrational Phase 3 studies, LEVEL and LEVEL-2. Enrollment is ongoing in the North American LEVEL study and LEVEL-2, a global study of TNX-103, remains on track to initiate in 2025.

To participate in the conference call, please dial one of the following numbers and ask to join the Tenax Therapeutics call:

  • +1-877-317-6789 for callers in the United States
  • +1-412-317-6789 for international callers

The live and archived webcast of the call will be accessible from the Company’s investor relations webpage.

About Levosimendan (TNX-101, TNX-102, TNX-103)

Levosimendan is a novel, first-in-class K-ATP channel activator/calcium sensitizer currently being evaluated to treat pulmonary hypertension (PH) associated with heart failure with preserved ejection fraction (PH-HFpEF). Levosimendan was first developed for intravenous use in hospitalized patients with acutely decompensated heart failure, and it has received market authorization in 60 countries in this indication, although it is not available in the United States or Canada. Tenax’s Phase 2 HELP study, including its open-label extension stage, demonstrated the potential of IV (TNX-101) and oral (TNX-103) levosimendan to bring durable improvements in exercise capacity and quality of life, as well as other clinical assessments, in patients with PH-HFpEF. TNX-103 (oral levosimendan) is currently being evaluated in LEVEL, a Phase 3, double-blind, randomized, placebo-controlled clinical trial in patients with PH-HFpEF.

About Tenax Therapeutics

Tenax Therapeutics, Inc. is a Phase 3, development-stage pharmaceutical company using clinical insights to develop novel cardiopulmonary therapies. The Company owns global rights to develop and commercialize levosimendan, which it is developing for the treatment of PH-HFpEF, the most prevalent form of pulmonary hypertension globally, for which no product has been approved to date. For more information, visit tenaxthera.com. Tenax Therapeutics’ common stock is listed on The Nasdaq Stock Market LLC under the symbol “TENX”.

Contact:

Investor and Media:

Argot Partners
tenax@argotpartners.com


FAQ

When is Tenax Therapeutics' virtual KOL call on TNX-103 scheduled (TENX)?

The call is scheduled for November 13, 2025 at 4:30 p.m. ET.

Who will speak on the Tenax (TENX) TNX-103 KOL call on November 13, 2025?

Tenax management will be joined by KOLs Barry A. Borlaug, M.D. and Sanjiv J. Shah, M.D..

What clinical programs for TNX-103 will Tenax discuss on the November 13, 2025 call?

The company will discuss its two registrational Phase 3 studies: LEVEL and LEVEL-2.

What is the enrollment status of Tenax's LEVEL and LEVEL-2 studies for TNX-103 (TENX)?

LEVEL enrollment is ongoing in North America; LEVEL-2 is on track to initiate in 2025.

How can investors access Tenax Therapeutics' live and archived webcast for the TNX-103 call?

The live and archived webcast will be accessible from Tenax Therapeutics' investor relations webpage.

What dial-in numbers are provided to join the Tenax (TENX) conference call on November 13, 2025?

U.S. callers: +1-877-317-6789; international callers: +1-412-317-6789.
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