Terns Pharmaceuticals, Inc. Stock Price, News & Analysis

Terns Pharmaceuticals announced positive results from the Phase 2a LIFT Trial of TERN-101, demonstrating significant decreases in cT1, a marker of liver inflammation and fibrosis, over 12 weeks of treatment. The trial showed TERN-101 to be safe and well-tolerated, correlating cT1 improvements with reduced clinical event risks. Additionally, Phase 1 data for TERN-501 indicated well-tolerated single doses leading to significant LDL decreases and SHBG increases, pointing to its potential efficacy in treating NASH. Both compounds are pivotal in Terns' NASH treatment strategy.

Terns Pharmaceuticals reported positive Phase 1 clinical trial results for TERN-501, a THR-β agonist targeting non-alcoholic steatohepatitis (NASH). The trial showed that TERN-501 was generally safe, well-tolerated, and demonstrated favorable pharmacokinetic properties with a half-life of over 13 hours. Significant reductions in LDL cholesterol of up to 28% and marked increases in sex hormone binding globulin were observed. Terns plans to initiate an FXR/THR-β agonist combination trial in NASH in the first half of 2022.

On October 18, 2021, Terns Pharmaceuticals announced three accepted abstracts for presentation at The Liver Meeting® Digital Experience 2021, focusing on their non-alcoholic steatohepatitis (NASH) programs. Key presentations include:

• TERN-101: Favorable safety and efficacy from the Phase 2a LIFT Study.
• TERN-501: Well-tolerated in first-in-human trials, showing dose-dependent cholesterol changes.

These findings underscore Terns' commitment to developing effective therapies for chronic liver diseases.

Terns Pharmaceuticals, a clinical-stage biopharmaceutical company, announced its participation in the H.C. Wainwright 5th Annual NASH Investor Conference set for October 12, 2021, at 2:30 p.m. ET. The company is focused on developing therapies for non-alcoholic steatohepatitis (NASH) and chronic liver diseases, featuring a portfolio that includes three clinical-stage programs and a preclinical program. A live audio webcast of the presentation will be available on Terns’ investor relations page, with a replay archived for 30 days.

Terns Pharmaceuticals has appointed Dr. Ann E. Taylor to its Board of Directors. With over 35 years in drug development, including her tenure as Chief Medical Officer at AstraZeneca, Dr. Taylor is expected to bring valuable expertise to Terns, particularly in developing treatments for non-alcoholic steatohepatitis (NASH) and chronic liver diseases. Terns is known for its innovative therapeutic approaches, including a diverse pipeline featuring small-molecule therapies aimed at addressing NASH.

Terns Pharmaceuticals has completed patient enrollment for Part 1 of the AVIATION Trial, a Phase 1b study for TERN-201, a selective VAP-1 inhibitor targeting chronic liver inflammation and fibrosis in NASH patients. Preliminary top-line data is expected in 1Q 2022. The trial aims to assess the safety and tolerability of TERN-201 in comparison to a placebo over 12 weeks. TERN-201 has shown promise in preclinical studies, and the company received FDA Fast Track Designation for the treatment of NASH.

Terns Pharmaceuticals, a clinical-stage biopharmaceutical company focused on therapies for non-alcoholic steatohepatitis (NASH), announced upcoming presentations at key investor conferences in September 2021. The conferences include the 2021 Virtual Wells Fargo Healthcare Conference on September 9, the H.C. Wainwright 23rd Annual Global Investment Conference on September 13, and the Oppenheimer Fall Healthcare Summit on September 20. Investors can access live webcasts on Terns' investor relations page, with replays available for 30 days.

Terns Pharmaceuticals reported financial results for Q2 2021, achieving significant clinical milestones in its NASH pipeline. The company initiated the Phase 1b AVIATION Trial for TERN-201 and completed a multiple ascending dose portion of the TERN-501 trial. Cash reserves are strong at $185.1 million, projected to last until 2024. Top-line data from TERN-501 is expected in 4Q 2021 and from TERN-201 in 1H 2022. Despite a net loss of $10.7 million for the quarter, decreased R&D expenses show a positive trend for operating efficiency.

Terns Pharmaceuticals, Inc. (Nasdaq: TERN), a clinical-stage biopharmaceutical company, has announced its participation in two key healthcare conferences. Management will join a liver disease panel at the 2021 Wedbush PacGrow Healthcare Conference on August 10 at 2:20 PM ET. Additionally, Terns will present at the Canaccord Genuity 41st Annual Growth Conference on August 11 at 1:00 PM ET. Both events will be available via live webcast on Terns' investor relations page, with replays accessible for 30 days post-presentation.