Tiziana Life Sciences Ltd Com Stock Price, News & Analysis

Tiziana Life Sciences plc (Nasdaq: TLSA / AIM: TILS) clarified its filing of a corrected amendment registration statement on Form F-6, which is not for a capital raise but to increase the number of American Depositary Shares (ADSs) for shareholder exchange. Each ADS represents two ordinary shares, and the trend of ordinary shares being exchanged for ADSs has grown recently. The company is also focused on developing drugs for various diseases, including Crohn’s disease and COVID-19, through its novel therapeutic candidates.

Tiziana Life Sciences (TLSA) announced a CEO interview detailing recent patent issuances, including anti-CD3 monoclonal antibodies for Crohn’s Disease and anti-IL-6 monoclonal antibodies for COVID-19. Key points discussed include the clinical pipeline for Foralumab and TZLS-501, intended for treating severe COVID-19 and hepatocellular carcinoma using Milciclib. Tiziana emphasizes its unique position with the fully human monoclonal antibody Foralumab in clinical development. The company is advancing its drug candidates aimed at various diseases.

Tiziana Life Sciences (Nasdaq: TLSA) announced the grant of a patent (No. 10,759,862) by the USPTO for its fully human monoclonal antibody, TZLS-501, aimed at treating COVID-19 and other pulmonary diseases. This antibody targets both IL-6R and IL-6, potentially alleviating cytokine storms in patients. The company plans to expedite clinical development, including GMP manufacturing and toxicology studies, to file an IND for clinical trials by Q1 2021. The patent strengthens Tiziana's IP portfolio as it seeks to utilize inhalation delivery for effective treatment.

Tiziana Life Sciences (Nasdaq: TLSA) announced that the USPTO granted a patent for the combination use of Milciclib with tyrosine kinase inhibitors (TKIs) for treating hepatocellular carcinoma (HCC). This patent (No. 10,758,541) will be published on September 1, 2020. Recent presentations at ASCO2020 highlighted Milciclib's favorable tolerance and promising activity in sorafenib-resistant HCC patients. The company aims to advance clinical evaluations for advanced and recurrent HCC cases. Dr. Shailubhai emphasized the need for combination therapies to overcome drug resistance in HCC.

Tiziana Life Sciences (Nasdaq: TLSA) has been granted a patent by the USPTO for treating Crohn’s disease with Foralumab, a fully human monoclonal antibody. This patent, effective from September 1, 2020, enhances the company's intellectual property portfolio. Tiziana's Phase 1 trial indicated Foralumab’s oral administration was well-tolerated, leading to plans for a Phase 2 trial for moderate-to-severe Crohn’s patients later this year. The innovative oral and nasal delivery methods aim to reduce toxicity and enhance treatment efficacy.

Tiziana Life Sciences (Nasdaq: TLSA) announced management team participation in the BTIG Biotechnology Conference on August 11, 2020, at 2:30 p.m. EDT. The event can be accessed through a live webcast via registration. Tiziana is focused on developing targeted drugs for cancer, inflammatory diseases, and COVID-19, with foralumab entering phase 2 studies for conditions like Crohn’s Disease and multiple sclerosis.

Foralumab is the world's only fully human anti-CD3 mAb in clinical development, with applications in autoimmune diseases.

Tiziana Life Sciences (Nasdaq: TLSA) announced the closure of a registered direct offering, issuing 11,009,615 American Depositary Shares (ADSs) at $5.20 per share, raising approximately $57.25 million. The proceeds will support clinical development of Foralumab, clinical trials for HCC patients with Milciclib, and expedite development of TZLS-501 for COVID-19. The total number of Ordinary Shares post-offering is now 190,559,823. ThinkEquity acted as the placement agent for the offering.

Tiziana Life Sciences plc (NASDAQ: TLSA) has signed agreements with four contract research organizations (CROs) to expedite the clinical development of TZLS-501, a fully human monoclonal antibody targeting IL-6R for COVID-19 treatment. The company plans to initiate human clinical trials in Q1 2021. Key partners include FHI Clinical, STC Biologics, Sciarra Labs, and ITR Laboratories Canada, which will assist with GMP manufacturing, safety studies, and inhalation technology. TZLS-501 aims to address cytokine release syndrome by depleting IL-6 levels directly in patients' lungs.

Tiziana Life Sciences (NASDAQ: TLSA) has reported issuing 2,043,000 ordinary shares in July 2020 under its ATM sales agreement, raising $4,371,289. The total number of ordinary shares now stands at 168,540,593, with each share providing one vote in company meetings. Tiziana is advancing its clinical programs, including phase 2 studies for Foralumab, a pioneering anti-CD3 monoclonal antibody aimed at treating autoimmune conditions like Crohn's Disease and multiple sclerosis, alongside developing treatments for COVID-19.