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Tiziana Life Sciences Ltd. develops intranasal foralumab, a fully human anti-CD3 monoclonal antibody, as a clinical-stage biotechnology company focused on neuroinflammatory and neurodegenerative diseases. News for TLSA centers on clinical and preclinical data for intranasal anti-CD3 therapy, including non-active secondary progressive multiple sclerosis, Multiple System Atrophy, Alzheimer’s disease, ALS, Long COVID-associated neuroinflammation, and age-related cognitive decline.
Company updates also cover biomarker work involving CSF proteomics, TSPO-PET and microglial activation, peer-reviewed publications, scientific conference presentations, expanded-access observations, and financing actions such as registered direct offerings of ordinary shares and warrants.
Tiziana Life Sciences (TLSA) announced the successful results of its pilot study on Foralumab, an intranasal anti-CD3 monoclonal antibody for COVID-19 treatment. The study showed a significant reduction in lung inflammation and pro-inflammatory biomarkers, including IL-6 and CRP. Treatment was well-tolerated with only mild adverse events reported. Following this, Tiziana plans to initiate a Phase 2 study in Brazil to further evaluate Foralumab's safety and efficacy in hospitalized COVID-19 patients. The promising data suggests a potential therapeutic benefit for immune hyperactivity in severe cases.
Tiziana Life Sciences (Nasdaq: TLSA) announced its ADS will trade ex-dividend from July 9, 2021. The non-cash dividend will consist of one Accustem Sciences Limited ADS, equivalent to two ordinary shares, for each TLSA ADS held. Payment of the dividend is scheduled for July 14, 2021. Shareholders who acquired TLSA ADS before the ex-dividend date are eligible for this dividend. For more details, refer to JP Morgan's notice.
Tiziana Life Sciences plc (Nasdaq: TLSA) announced that the SEC has declared effective the Forms 20-F and F-6 filed by Accustem Sciences Limited, allowing the completion of the spin-off of Accustem. Key dates include the demerger record time on October 30, 2020, and the issuance of Accustem shares to Tiziana shareholders starting July 8, 2021. Existing Tiziana DRs will remain valid without requiring exchange for new DRs.
Tiziana Life Sciences plc (NASDAQ: TLSA, LSE: TILS) has announced an interview with Dr. Howard Weiner, Chairman of its Scientific Advisory Board, to air on Bloomberg Markets today. The company focuses on innovative therapeutics in oncology and immunology, notably developing Milciclib for cancer and Foralumab for various autoimmune diseases including COVID-19 and multiple sclerosis. Foralumab is recognized as the only second-generation fully human anti-CD3 monoclonal antibody in clinical development globally.
Tiziana Life Sciences held its Annual General Meeting on June 25, 2021, where all resolutions were approved. The company announced the re-activation of its strategic plan to redomicile to Bermuda, with further information to be provided to shareholders. The results of proxy voting will be available on the company's website.
Tiziana Life Sciences focuses on developing novel therapies in oncology and immunology, including Milciclib and Foralumab, a second generation human anti-CD3 monoclonal antibody for various autoimmune diseases.
Tiziana Life Sciences (NASDAQ: TLSA) has entered into an agreement with FHI Clinical to conduct a Phase 2 proof-of-concept study in Brazil, evaluating the safety and efficacy of intranasal Foralumab for severe COVID-19 patients. This randomized, placebo-controlled trial aims to build on earlier findings in non-hospitalized patients. It will involve up to 80 participants with pulmonary inflammation, assessing various health metrics after 14 days of treatment. This pivotal study is expected to enhance the understanding of Foralumab's potential in treating COVID-19-related complications.
Tiziana Life Sciences has appointed Dr. Kevin Schutz as Vice-President of Regulatory Affairs, strengthening its global development capabilities. Dr. Schutz, with over 19 years in the pharmaceutical sector, will manage regulatory interactions for clinical studies across the U.S., Europe, and Asia. His expertise includes working with regulatory agencies such as the FDA and EMA, essential for the company’s clinical pursuits. Tiziana focuses on innovative treatments for diseases like multiple sclerosis and COVID-19, with its lead candidate, Foralumab, showing promise for various indications.
Tiziana Life Sciences (NASDAQ: TLSA) has submitted a grant proposal to the UK COVID Therapeutics Advisory Panel to advance the clinical development of Foralumab, an innovative nasal treatment for non-hospitalized COVID-19 patients. This initiative aligns with the UK government's call for at-home therapies. Previous studies in Brazil showed that Foralumab effectively reduced lung inflammation in COVID-19 patients. Additionally, a separate clinical trial for hospitalized patients is in the works. Foralumab could potentially address various COVID-19 variants, enhancing treatment options.
Tiziana Life Sciences has announced that its Notice of Annual General Meeting (AGM) is now available on its website. The AGM is scheduled for June 25, 2021, at 10:00 am BST and will be conducted electronically due to ongoing Covid-19 restrictions. Shareholders are encouraged to submit their proxy votes and any questions in advance to facilitate the meeting. Full details of the AGM procedures are outlined in the Notice of AGM.
Tiziana Life Sciences (NASDAQ: TLSA) announced positive results from its Phase 1 trial of nasally administered Foralumab, showing significant immunomodulatory effects. Conducted at Brigham and Women’s Hospital, the study demonstrated that a 50 mcg/day dose led to favorable changes in cytotoxic T-cell subsets and inflammatory biomarkers without severe toxicity. These findings support further clinical development, primarily targeting progressive MS. Tiziana's innovative approach may enhance treatment outcomes for neurodegenerative diseases.