Welcome to our dedicated page for Tiziana Life Sciences Com news (Ticker: TLSA), a resource for investors and traders seeking the latest updates and insights on Tiziana Life Sciences Com stock.
Tiziana Life Sciences Ltd. (NASDAQ: TLSA) is a clinical-stage biopharmaceutical company whose news flow centers on the development of intranasal foralumab, a fully human anti-CD3 monoclonal antibody, and related immunomodulation programs. Company announcements highlight progress in neuroinflammatory and neurodegenerative indications, including non-active secondary progressive multiple sclerosis, early Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS).
News about Tiziana often covers key clinical milestones. Recent releases describe dosing of patients in a Phase 2 randomized, placebo-controlled trial of intranasal foralumab in early Alzheimer’s disease, including evaluation as monotherapy and in combination with FDA-approved anti-amyloid therapies lecanemab and donanemab. Other updates report on the Expanded Access Program in non-active secondary progressive multiple sclerosis and the acceptance of the company’s ALS Phase 2 trial into the ALS MyMatch Program at the Sean M. Healey & AMG Center for ALS.
Investors following TLSA news can also expect regulatory and safety updates, such as the submission of Development Safety Update Reports to the U.S. Food and Drug Administration, which summarize cumulative exposure and safety findings for intranasal foralumab. Corporate and capital markets news includes insider share purchases by senior leadership, decisions regarding proposed public offerings, and participation in industry conferences like BIO-Europe, the Jefferies London Healthcare Conference, and neuroscience-focused forums.
This news page aggregates these company-issued press releases and related coverage, giving readers a centralized view of Tiziana’s clinical progress, regulatory interactions, strategic initiatives such as the planned spinout of IL-6 asset TZLS-501, and visibility events like ringing the Nasdaq Closing Bell. Users interested in TLSA can review this feed to monitor how Tiziana’s immunotherapy and drug delivery programs evolve over time.
Tiziana Life Sciences plc (NASDAQ: TLSA) announced a change in its sponsored Level 3 American Depositary Receipt (ADR) programme. ADR holders will receive 1.5 additional ADRs for each existing ADR held as of the record date, July 27, 2020, instead of the previously stated 2.5. Existing ADRs remain valid without requiring exchange. The register at JPMorgan will close for issuances and cancellations from July 27, 2020, and will reopen on August 4, 2020. Tiziana focuses on developing novel molecules to treat diseases including oncology and autoimmunity.
Tiziana Life Sciences plc (NASDAQ: TLSA) has announced a ratio change in its sponsored Level 3 American Depositary Receipt (ADR) program, transitioning to a 2.5 for 1 forward split. This adjustment, effective July 31, 2020, alters the ratio from five ordinary shares for one ADR to two ordinary shares per ADR. The change will increase the number of ADSs without affecting the underlying shares or their nominal values. Existing ADR holders will receive 2.5 additional ADRs for each ADR held as of July 27, 2020, the record date.
Tiziana Life Sciences (TLSA) announced an upcoming interview with CEO Kunwar Shailubhai on The RedChip Money Report scheduled for July 12, 2020. The interview will discuss the company's development pipeline and milestones, airing on Bloomberg International and other US channels. Tiziana focuses on innovative treatments for cancer and autoimmune diseases, including Foralumab, a monoclonal antibody in clinical development. The company cautions that forward-looking statements are subject to risks and uncertainties that may affect actual results.
Tiziana Life Sciences announced an agreement with STC Biologics for GMP manufacturing of TZLS-501, a monoclonal antibody targeting IL-6 receptors, developed for COVID-19 treatment. Tiziana is also advancing inhalation technology for direct delivery of TZLS-501 into the lungs, potentially enhancing efficacy against the disease. A patent application for this technology was submitted. The company aims to submit an Investigational New Drug (IND) application in Q1 2021, leveraging the dual mechanism of TZLS-501 to block IL-6 signaling and deplete IL-6 levels to mitigate cytokine storms in COVID-19 patients.
Tiziana Life Sciences (Nasdaq: TLSA) announced the United States Patent and Trademark Office granted a patent for its oral administration technology of Foralumab, a fully human anti-CD3 monoclonal antibody. This patent marks a historic development for immunotherapies, enabling non-intravenous treatments for diseases like Crohn’s and Alzheimer’s. The patent encompasses stabilized formulations for oral and nasal administration, enhancing therapeutic options while minimizing traditional administration toxicities. Tiziana plans to advance clinical trials evaluating Foralumab in moderate-to-severe Crohn’s Disease patients.
Tiziana Life Sciences plc (NASDAQ: TLSA) has announced that Gregor MacRae is stepping down as a director effective immediately. Gabriele Cerrone, the Chairman, expressed gratitude for MacRae's contributions and indicated ongoing efforts to recruit a new non-executive director with significant NASDAQ audit committee experience. The company is hopeful for a formal announcement regarding this new appointment soon. This announcement contains inside information as defined by EU Regulation 596/2014.
Tiziana Life Sciences (TLSA) announced that Dr. Howard Weiner has secured a NIH grant for research on nasal anti-CD3 in Alzheimer’s therapy. Preclinical studies indicate potential for the nasal administration of Foralumab to slow disease progression. The company has an exclusive license for this method from Brigham and Women’s Hospital. Following two completed Phase 1 trials, TLSA plans to initiate Phase 2 trials for Foralumab in treating progressive multiple sclerosis and Crohn’s disease. Alzheimer’s, a leading cause of dementia, underscores the urgency for innovative treatments.
Tiziana Life Sciences (NASDAQ: TLSA) announced plans to demerge its StemPrintER and SPARE genomics-based personalized medicine businesses into a separate entity. This move follows promising trial results from the European Institute of Oncology, indicating StemPrintER's potential as a standalone business. The Board aims to secure funding and allow focused growth for StemPrintER, enhancing shareholder value. Shareholder approval for a capital reduction necessary for the demerger will be sought at the upcoming Annual General Meeting, although there are no guarantees for completion.
Tiziana Life Sciences (NASDAQ: TLSA) announced the online publication of two abstracts on its drug Milciclib at the ASCO20 meeting. The Phase 2a study showed Milciclib was well-tolerated in sorafenib-resistant hepatocellular carcinoma (HCC) patients, meeting primary endpoints with no drug-related deaths. Results indicated a 61% clinical benefit rate and a median progression-free survival of 5.9 months. Additionally, preliminary data from an ongoing trial combining Milciclib with Regorafenib showed a 20% reduction in AFP levels in liver transplant patients with recurrent HCC.
Tiziana Life Sciences plc (Nasdaq: TLSA) announces a new study on its StemPrintER genomic tool, showing its superiority over Oncotype DX in predicting breast cancer recurrence. Presented by scientists at the European Institute of Oncology at the upcoming ASCO Virtual Conference, the study highlights StemPrintER’s advanced prognostic capabilities in ER+/HER2- breast cancer patients. An additional model, SPARE, further refines distant metastasis predictions. This advancement reinforces Tiziana’s position in precision medicine and opens new business avenues beyond existing therapeutic pipelines.
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