Tenaya Therapeutics Announces Publication of TN-401 Gene Therapy Preclinical Data in Nature Communications Medicine
Tenaya Therapeutics Announces Positive Preclinical Results for TN-401 Gene Therapy in Treating ARVC, Aiming to Address Underlying Genetic Cause of Disease
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Tenaya Therapeutics published preclinical research on TN-401 gene therapy in Nature Communications Medicine
TN-401 is an AAV9-based gene therapy targeting PKP2 gene mutations causing ARVC
TN-401 showed promising results in restoring PKP2 protein levels and improving heart function in a severe mouse model of ARVC
The gene therapy aims to prevent, halt, or reverse the progression of PKP2-associated ARVC
Tenaya anticipates dosing the first patient in the Phase 1b RIDGE-1 clinical trial in the second half of 2024
The recent preclinical findings for Tenaya Therapeutics' gene therapy candidate, TN-401, signify a notable advancement in the treatment of arrhythmogenic right ventricular cardiomyopathy (ARVC), particularly the PKP2-associated variant. ARVC is a genetic condition that disrupts normal heart rhythms and can lead to sudden cardiac death, representing an unmet medical need with limited therapeutic options.
The use of adeno-associated virus serotype 9 (AAV9) as a vector is a strategic choice, leveraging its safety profile and heart-targeting capabilities. The positive outcomes observed in mouse models, including the restoration of PKP2 protein levels and improvement in heart function, suggest a potential breakthrough in halting or reversing the disease's progression. These results may have significant implications for patients, potentially reducing the frequency of arrhythmias and improving quality of life.
However, it's important to approach these findings with cautious optimism. The transition from preclinical to clinical efficacy is fraught with challenges and the safety and efficacy in humans remain to be validated. The upcoming Phase 1b RIDGE-1 clinical trial will be a critical step in determining TN-401's viability as a therapeutic option. If successful, this therapy could address a significant market gap and offer a competitive edge for Tenaya Therapeutics, with potential long-term impacts on the company's valuation and the broader biotech sector.
From a market perspective, Tenaya Therapeutics' development of TN-401 could be a game-changer for both the company and the biotechnology industry focused on cardiovascular diseases. The preclinical success of TN-401 in a severe mouse model of ARVC positions Tenaya as a pioneer in gene therapy for heart diseases, a niche yet rapidly growing segment of the biotech market.
The announcement of the Phase 1b clinical trial commencement is likely to generate investor interest, considering the high stakes of gene therapy and the significant patient population suffering from ARVC. Positive trial outcomes could lead to increased investor confidence and potentially drive up Tenaya's stock price. Moreover, the company's strategic focus on a one-time treatment solution could disrupt the current treatment paradigm, which often involves lifelong medication and management.
It's important to note that the biotech sector is highly volatile, with stock prices sensitive to clinical trial results and regulatory news. Investors will be closely monitoring the progress of the RIDGE-1 trial for any indication of TN-401's clinical efficacy and safety. The anticipation of these results could introduce volatility in Tenaya's stock as the trial progresses. Long-term implications for the company's financial health will largely depend on the trial outcomes, regulatory approvals and the therapy's market penetration post-commercialization.
As a specialist in the genetic aspects of cardiovascular diseases, the development of TN-401 is a significant stride in personalized medicine for cardiology. ARVC, particularly the PKP2-associated type, has been a challenging condition due to its genetic basis and the consequent structural and electrical abnormalities it induces in the heart. Gene therapy offers a targeted approach that could rectify the underlying genetic defect, a concept that has long been theoretical but is now inching closer to clinical application.
The choice of AAV9 as a vector is informed by its cardiac tropism and prior safety data, which is reassuring. However, the scalability of this therapy, potential immune responses to the vector and long-term expression of the transgene are aspects that will require close scrutiny in human trials. The therapeutic efficacy of TN-401 in a human population will depend on how well these preclinical findings translate, which includes not only the restoration of PKP2 protein but also the correction of the broader network of genes involved in cellular integrity and function.
The upcoming RIDGE-1 trial will be pivotal in understanding the real-world application of this therapy. If the trial confirms the preclinical findings, it could revolutionize the treatment landscape for ARVC and potentially other genetic cardiomyopathies, setting a precedent for gene therapy in cardiology.
03/18/2024 - 08:30 AM
TN-401 AAV9-Based Gene Therapy Being Developed to Treat the Underlying Cause of PKP2-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
PKP2 Gene Replacement Therapy Normalized Heart Rhythms, Reversed Disease Progression and Extended Survival in a Severe Mouse Model of Disease
Tenaya Anticipates Dosing First Patient in Phase 1b RIDGE™-1 Clinical Trial of TN-401 in Second Half of 2024
SOUTH SAN FRANCISCO, Calif., March 18, 2024 (GLOBE NEWSWIRE) -- Tenaya Therapeutics, Inc. (NASDAQ: TNYA), a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease, today announced the publication of its preclinical research related to its gene therapy candidate, TN-401, in the current issue of Nature Communications Medicine .
TN-401 is an adeno-associated virus serotype 9 (AAV9)-based gene therapy being developed for the treatment of arrhythmogenic right ventricular cardiomyopathy (ARVC) caused by Plakophilin-2 (PKP2 ) gene mutations. PKP2 mutations are the most common genetic cause of ARVC, also known as arrhythmogenic cardiomyopathy (ACM), and result in a loss of key proteins needed to maintain the structural integrity and cell-to-cell electrical signaling of heart muscle cells. TN-401 is designed to deliver a functional PKP2 gene to heart cells where it works to restore normal protein levels in order to halt or even reverse disease after a single dose.
“Following a single infusion of our AAV9-based PKP2 gene therapy in a severe knock-out mouse model of the disease, PKP2 protein levels were restored. This led to dose-dependent improvements in right ventricular dilation and ejection fraction, reductions in arrhythmia frequency and severity, and prevention of adverse fibrotic remodeling, with near-maximal efficacy achieved at the 3E13 vg/kg dose.” said Tim Hoey, Ph.D., Chief Scientific Officer of Tenaya.
“ARVC can have a devastating effect on patients’ lives, putting them at risk of life-threatening arrhythmias and placing limitations on their quality of life,” said Whit Tingley, M.D., Ph.D., Chief Medical Officer of Tenaya. “These promising preclinical results show the potential of TN-401 to prevent, halt or even reverse the steady progression of PKP2 -associated ARVC by addressing the underlying genetic cause, and offer hope to patients. We look forward to commencing dosing of TN-401 in patients with PKP2 -associated ARVC in our Phase 1b RIDGE-1 clinical trial in the second half of this year.”
Tenaya’s RIDGE-1 Phase 1b clinical trial of TN-401 is a multi-center, open-label study to assess the safety, tolerability and clinical efficacy of a one-time intravenous infusion of TN-401. Tenaya is currently also conducting the RIDGE™ global non-interventional natural history and serotype study of PKP2 -associated ARVC. Both studies are being conducted at leading centers for ARVC care.
Key Findings AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy ,” describes results from preclinical studies in a Pkp2 -deficient mouse model to understand gene therapy’s impact in both prevention mode before disease onset and in treatment mode after disease onset. A single dose of Tenaya’s AAV9:PKP2 gene therapy:
Restored normal levels of PKP2 protein expression, Led to a highly coordinated and durable correction in structural genes encoding desmosome, sarcomere and calcium handling proteins with a role in maintaining cellular integrity and function, Reduced the frequency and severity of arrhythmias, Demonstrated durable efficacy in preventing disease development, Slowed or reversed disease progression after onset, Prevented fibrotic remodeling, and Improved long-term survival. Tenaya selected AAV9 as the vector for delivery for TN-401 based on its extensive clinical and commercial safety record in thousands of patients globally and its demonstrated ability in clinical studies to broadly distribute in all regions of the human heart and to more robustly express the PKP2 gene in cardiomyocytes as compared to other vectors.
About PKP2 -Associated ARVC PKP2 are the most frequent cause of ARVC, with greater than 40% of those diagnosed estimated to carry pathogenic PKP2 mutations. In the U.S. prevalence of PKP2 -associated ARVC is estimated at more than 70,000, though the condition is frequently undiagnosed; in nearly one in four cases, sudden cardiac death is the first sign of disease.
Mutations of the PKP2 gene result in insufficient expression of a protein needed for the proper functioning of the desmosomal complex that maintains physical connections and electrical signaling between heart muscle cells. As the desmosome structure degrades, cardiac muscle cells are replaced by fibrofatty tissue and electrical pulses in the heart become unstable, resulting in adverse remodeling and irregular heart rhythms. A progressive disease, ARVC is typically diagnosed before age 40 and symptoms may include arrhythmias, palpitations, lightheadedness, dizziness and fainting and sudden cardiac arrest. Current treatments include anti-arrhythmic medications, implantable cardioverter-defibrillators (ICDs) and ablation procedures, which do not address the underlying genetic cause of disease.
About TN-401 Gene Therapy and the RIDGE Clinical Program PKP2 gene. Tenaya has received clearance from the FDA to initiate its first-in-human RIDGE-1 Phase 1b clinical trial of TN-401 in patients with PKP2 -associated ARVC. To support TN-401’s clinical development, the company is currently enrolling the RIDGE global non-interventional study to collect natural history and AAV9 antibody (seroprevalence) data among ARVC patients carrying PKP2 gene mutations. TN-401 has received Orphan Drug and Fast Track Designations from the FDA.
About Tenaya Therapeutics MYBPC3 -associated hypertrophic cardiomyopathy (HCM), TN-401, a gene therapy for PKP2 -associated arrhythmogenic right ventricular cardiomyopathy (ARVC), and TN-301, a small molecule HDAC6 inhibitor being initially developed for heart failure with preserved ejection fraction (HFpEF). Tenaya also has multiple early-stage programs progressing through preclinical development. For more information, visit www.tenayatherapeutics.com .
Forward Looking Statements PKP2 -associated ARVC and the plan for initiation of patient dosing in RIDGE-1. The forward-looking statements contained herein are based upon Tenaya’s current expectations and involve assumptions that may never materialize or may prove to be incorrect. These forward-looking statements are neither promises nor guarantees and are subject to a variety of risks and uncertainties, including but not limited to: the potential failure of TN-401 to demonstrate safety and/or efficacy in clinical testing; unexpected concerns that may arise as a result of the occurrence of adverse safety events or additional data analyses of clinical trials evaluating TN-401; the timing and progress of the RIDGE-1 clinical trial; the timing, scope and likelihood of regulatory filings and approvals for TN-401; risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics and operating as an early stage company; Tenaya’s ability to develop, initiate or complete preclinical studies and clinical trials, and obtain approvals, for any of its product candidates; Tenaya’s continuing compliance with applicable legal and regulatory requirements; Tenaya’s ability to raise any additional funding it will need to continue to pursue its business and product development plans; Tenaya’s reliance on third parties; Tenaya’s manufacturing, commercialization and marketing capabilities and strategy; the loss of key scientific or management personnel; competition in the industry in which Tenaya operates; Tenaya’s ability to obtain and maintain intellectual property protection for its product candidates; general economic and market conditions; and other risks. Information regarding the foregoing and additional risks may be found in the section entitled “Risk Factors” in documents that Tenaya files from time to time with the Securities and Exchange Commission. These forward-looking statements are made as of the date of this press release, and Tenaya assumes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.
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What is the gene therapy candidate being developed by Tenaya Therapeutics for the treatment of ARVC?
Tenaya Therapeutics is developing TN-401, an AAV9-based gene therapy targeting PKP2 gene mutations causing ARVC.
What were the key findings of the preclinical studies on TN-401 gene therapy?
The preclinical studies showed that TN-401 restored normal levels of PKP2 protein expression, reduced arrhythmias, prevented disease development, and improved long-term survival.
When does Tenaya Therapeutics anticipate dosing the first patient in the Phase 1b RIDGE-1 clinical trial?
Tenaya Therapeutics expects to dose the first patient in the Phase 1b RIDGE-1 clinical trial in the second half of 2024.
Why did Tenaya Therapeutics select AAV9 as the vector for TN-401 delivery?
Tenaya chose AAV9 for TN-401 delivery due to its safety record, ability to distribute in all regions of the human heart, and robust expression of the PKP2 gene in cardiomyocytes.
