Welcome to our dedicated page for Trevi Therapeutics news (Ticker: TRVI), a resource for investors and traders seeking the latest updates and insights on Trevi Therapeutics stock.
Trevi Therapeutics, Inc. (TRVI) is a clinical-stage biopharmaceutical company advancing Haduvio™, an investigational oral therapy targeting chronic cough in idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC), along with pruritic conditions like prurigo nodularis. This page provides comprehensive access to official company announcements, clinical trial updates, and strategic developments.
Investors and industry professionals will find curated updates on TRVI's research programs, regulatory milestones, and financial performance. Our news collection includes details on Haduvio's dual opioid receptor mechanism, trial design specifics, and collaborative initiatives – all essential for evaluating the company's scientific and commercial trajectory.
Key content categories include clinical trial results, FDA communications, intellectual property updates, executive leadership changes, and financial disclosures. Each update is presented with contextual clarity to serve both expert analysts and those new to biopharma investing.
Bookmark this page for streamlined access to TRVI's evolving story as it progresses through critical development phases. Check regularly for verified updates on therapeutic advancements directly from company filings and authorized communications.
Trevi Therapeutics (NASDAQ: TRVI) reported significant progress in its clinical trials for Haduvio, a therapy for chronic cough conditions. The company announced positive topline data from Phase 2a RIVER trial showing a 57% placebo-adjusted reduction in 24-hour cough frequency for refractory chronic cough patients.
Key developments include completed enrollment in the Phase 2b CORAL trial for IPF chronic cough patients, with topline data expected in Q2 2025, and positive sample size re-estimation outcome requiring no changes to the study. The company also reported positive results from its Human Abuse Potential study.
Financial highlights for Q4 2024:
- Cash position: $107.6 million, with runway into H2 2026
- R&D expenses: $9.3 million (up from $6.5M in Q4 2023)
- Net loss: $11.4 million (compared to $7.8M in Q4 2023)
Trevi Therapeutics (NASDAQ: TRVI) has scheduled its fourth quarter and year-end 2024 financial results announcement and corporate update for March 18, 2025, at 4:30 p.m. ET. The company, which is developing Haduvio™ (oral nalbuphine ER) for chronic cough treatment in patients with idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC), will host a conference call and live audio webcast.
Participants can join via phone at (877) 870 4263 (domestic) or (412) 317 0790 (international). The webcast will be available through the 'Investors & News' section on Trevi's website, with a 30-day replay option available after the event.
Trevi Therapeutics (NASDAQ: TRVI) announced positive topline results from its Phase 2a RIVER trial evaluating Haduvio for refractory chronic cough (RCC). The trial met its primary endpoint with a 57% placebo-adjusted reduction in 24-hour cough frequency (p<0.0001).
Key findings include:
- 67% reduction in cough frequency from baseline
- 66% reduction in severe cough subgroup
- 68% reduction in moderate cough subgroup
- 84% of Haduvio patients achieved at least 30% reduction in cough frequency vs 29% for placebo
The trial involved 66 patients in a randomized, double-blind, placebo-controlled crossover study. Significant improvements were observed as early as Day 7 at the lowest dose (27mg BID). Common side effects included constipation, nausea, somnolence, headache, dizziness, and fatigue, with no serious adverse events reported.
Trevi Therapeutics (NASDAQ: TRVI) has scheduled a conference call and webcast for March 10th, 2025, at 8:30 a.m. ET to present topline results from their Phase 2a RIVER trial of Haduvio™. The trial evaluates oral nalbuphine ER for treating chronic cough in patients with idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC).
The presentation will include audio and slides, accessible via webcast. Participants can join by dialing (877) 870 4263 (domestic) or (412) 317 0790 (international). A 30-day replay will be available on the company's website after the event.
Trevi Therapeutics (Nasdaq: TRVI), focused on developing Haduvio™ (oral nalbuphine ER) for chronic cough treatments, has announced its participation in three major investor conferences this March.
The schedule includes:
- TD Cowen 45th Annual Health Care Conference (March 3-5) in Boston, featuring a corporate presentation on March 4 at 10:30 AM ET by CFO Lisa Delfini and CCO Farrell Simon
- Leerink Partners Global Healthcare Conference (March 10-12) in Miami, with a presentation on March 12 at 8:00 AM ET by CEO Jennifer Good and CDO James Cassella
- Leerink Partners Mountain Meeting (March 23-26) in Jackson Hole, with CFO Lisa Delfini representing
All events will feature corporate presentations available to in-person attendees.
Trevi Therapeutics (NASDAQ: TRVI) has completed enrollment in its Phase 2b CORAL trial of Haduvio™ (oral nalbuphine ER) for treating chronic cough in patients with idiopathic pulmonary fibrosis (IPF). Topline results are expected in the first half of 2025.
The CORAL trial is evaluating three doses of Haduvio (27mg, 54mg, and 108mg twice daily) against placebo in approximately 160 IPF patients with chronic cough over a 6-week period. The study includes a 2-week titration period followed by 4 weeks of fixed dosing.
The primary endpoint measures the relative change in 24-hour cough frequency at Week 6 versus baseline, using an objective cough monitor. Secondary endpoints include patient-reported outcome measures for cough.
According to James Cassella, Chief Development Officer, chronic cough significantly impacts IPF patients, and current treatments are often ineffective, creating a substantial unmet need. Results will help determine optimal doses for the pivotal Phase 3 program.
Trevi Therapeutics (Nasdaq: TRVI), a clinical-stage biopharmaceutical company, has announced its participation in three major investor conferences this February. The company, which is developing Haduvio™ (oral nalbuphine ER) for chronic cough treatment in idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC), will be represented by key executives at these events.
The conferences include the Piper Sandler Biopharma Mogul Summit (February 2-4) in Park City, Utah, where CFO Lisa Delfini will attend; the Oppenheimer Healthcare 2025 Winter CEO & Investor Summit (February 3-6) in Vail, Colorado, featuring CEO Jennifer Good; and the Oppenheimer 35th Annual Healthcare Life Sciences Virtual Conference (February 11-12), where Jennifer Good and Chief Development Officer James Cassella will deliver a corporate presentation on February 11 at 9:20 AM ET.
Trevi Therapeutics (NASDAQ: TRVI) provided key updates on its clinical trials and financial position. The company completed patient visits for its Phase 2a RIVER trial in refractory chronic cough (RCC), with topline results expected in Q1 2025. The Phase 2b CORAL trial in idiopathic pulmonary fibrosis (IPF) patients with chronic cough is approximately 80% enrolled, with results anticipated in H1 2025.
The company recently announced positive outcomes from both the sample size re-estimation analysis of the Phase 2b CORAL trial and their Human Abuse Potential study. Trevi's preliminary estimate indicates cash, cash equivalents, and marketable securities of $107.6 million as of December 31, 2024, providing runway into H2 2026.
Trevi Therapeutics (TRVI) has announced the pricing of an underwritten offering of 12,500,000 shares of common stock at $4.00 per share, aiming to raise $50 million before deducting underwriting costs. The offering, expected to close on December 17, 2024, includes participation from notable investors such as Adage Capital Partners LP, Frazier Life Sciences, and Vivo Capital.
The company, which is developing Haduvio™ (oral nalbuphine ER) for chronic cough treatment in idiopathic pulmonary fibrosis and refractory chronic cough, is conducting the offering through a shelf registration statement previously filed with the SEC. Leerink Partners, Stifel, and Oppenheimer & Co. are serving as joint book-running managers.
Trevi Therapeutics (NASDAQ: TRVI) announced positive results from its planned sample size re-estimation (SSRE) for the Phase 2b CORAL trial, confirming no changes needed to the current sample size of 160 patients. The trial, testing Haduvio™ for chronic cough in idiopathic pulmonary fibrosis (IPF) patients, has reached 75% enrollment, with topline results expected in H1 2025.
The SSRE analysis, conducted on the highest dose (108mg twice daily) after 80 patients completed treatment, supported maintaining the pre-specified conditional power of 80% or greater. The CORAL trial is evaluating three doses of Haduvio (27mg, 54mg, and 108mg twice daily) against placebo in IPF patients with chronic cough, with the primary endpoint measuring relative change in 24-hour cough frequency.
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