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Taysha Gene Therapies Announces Poster Presentation on TSHA-102 in Rett Syndrome at Upcoming British Paediatric Neurology Association 2024 Annual Conference

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Taysha Gene Therapies, Inc. (Nasdaq: TSHA) will present clinical data on its TSHA-102 program for Rett syndrome at the British Paediatric Neurology Association (BPNA) 2024 Annual Conference. The presentation will include previously disclosed clinical data from the first two adult patients with stage four Rett syndrome dosed with TSHA-102 in the REVEAL Phase 1/2 adolescent and adult trial in Canada. The Company expects to provide further updates on available clinical data from cohort one (low dose) in the REVEAL trial in the first quarter of 2024.
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DALLAS, Jan. 22, 2024 (GLOBE NEWSWIRE) -- Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a clinical-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS), today announced that it will present clinical data on its TSHA-102 program in evaluation for Rett syndrome during an oral poster presentation at the upcoming British Paediatric Neurology Association (BPNA) 2024 Annual Conference, taking place in Bristol, England from January 24-26, 2024.

The presentation will include previously disclosed clinical data from the first two adult patients with stage four Rett syndrome dosed with TSHA-102 in the REVEAL Phase 1/2 adolescent and adult trial in Canada. The Company expects to provide further updates on available clinical data from cohort one (low dose) in the REVEAL adolescent and adult trial in the first quarter of 2024.

Oral poster presentation details are as follows:

Abstract Title: Early safety and efficacy observations following the first use of TSHA-102 gene therapy in patients with Rett Syndrome

Presenter: Meredith Schultz, M.D., M.S., Senior Vice President of Clinical Development and Medical Affairs at Taysha Gene Therapies

Oral Presentation Session Date/Time: Thursday, January 25 at 12:05-12:40 PM GMT

Location: Screen C - Wallace Suite

Poster Number: 056

Additional details on the meeting can be found at the BPNA 2024 Annual Congress website.

About TSHA-102
TSHA-102 is a self-complementary intrathecally delivered AAV9 investigational gene transfer therapy in clinical evaluation for Rett syndrome. TSHA-102 utilizes a novel miRNA-Responsive Auto-Regulatory Element (miRARE) technology designed to mediate levels of MECP2 in the CNS on a cell-by-cell basis without risk of overexpression. TSHA-102 has received Fast Track designation and Orphan Drug and Rare Pediatric Disease designations from the FDA and has been granted Orphan Drug designation from the European Commission.

About Rett Syndrome
Rett syndrome is a rare neurodevelopmental disorder caused by mutations in the X-linked MECP2 gene, which is a gene that’s essential for neuronal and synaptic function in the brain. The disorder is characterized by intellectual disabilities, loss of communication, seizures, slowing and/or regression of development, motor and respiratory impairment, and shortened life expectancy. Rett syndrome primarily occurs in females and is one of the most common genetic causes of severe intellectual disability. Currently, there are no approved disease-modifying therapies that treat the genetic root cause of the disease. Rett syndrome caused by a pathogenic/likely pathogenic MECP2 mutation is estimated to affect between 15,000 and 20,000 patients in the U.S., EU and U.K.

About Taysha Gene Therapies
Taysha Gene Therapies (Nasdaq: TSHA) is on a mission to eradicate monogenic CNS disease. With a singular focus on developing curative medicines, we aim to rapidly translate our treatments from bench to bedside. We have combined our team’s proven experience in gene therapy drug development and commercialization with the world-class UT Southwestern Gene Therapy Program. Together, we leverage our fully integrated platform with a goal of dramatically improving patients’ lives. More information is available at www.tayshagtx.com.

Company Contact:
Hayleigh Collins
Director, Head of Corporate Communications and Investor Relations
Taysha Gene Therapies, Inc.
hcollins@tayshagtx.com

Media Contact:
Carolyn Hawley
Canale Communications
carolyn.hawley@canalecomm.com


FAQ

What is the focus of Taysha Gene Therapies, Inc. (TSHA)?

Taysha Gene Therapies, Inc. (TSHA) focuses on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system (CNS).

What is the TSHA-102 program?

The TSHA-102 program is a gene therapy program being evaluated for Rett syndrome.

Where will the clinical data on TSHA-102 be presented?

The clinical data on TSHA-102 will be presented at the British Paediatric Neurology Association (BPNA) 2024 Annual Conference in Bristol, England.

Who will be presenting the clinical data on TSHA-102?

Meredith Schultz, M.D., M.S., Senior Vice President of Clinical Development and Medical Affairs at Taysha Gene Therapies, will be presenting the clinical data on TSHA-102.

When will the oral poster presentation take place?

The oral poster presentation will take place on Thursday, January 25 at 12:05-12:40 PM GMT.

Where can additional details on the meeting be found?

Additional details on the meeting can be found at the BPNA 2024 Annual Congress website.

Taysha Gene Therapies, Inc.

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About TSHA

taysha gene therapies, inc., a gene therapy company, develops adeno-associated virus based gene therapies for the treatment of monogenic diseases of the central nervous system. it primarily develops tsha-101 for the treatment of gm2 gangliosidosis; tsha-118 for the treatment of cln1 disease; tsha-102 for the treatment of rett syndrome; tsha-103 for the treatment of slc6a1 haploinsufficiency disorder; and tsha-104 for the treatment for surfeit locus 1 deficiency. the company also has strategic partnership with the university of texas southwestern medical center to develop and commercialize transformative gene therapy treatments. taysha gene therapies, inc. was founded in 2019 and is based in dallas, texas.