Therapeutic Solutions International Announces Antigen Specific Blockade of Pathological Immune Response in Multiple Sclerosis Model Using “Tattoo Gun” Immunization
Secondary Finding Demonstrates Tattooing Skin with Tolerogenic Genes AIRE or FoxP3 “Balances” Immune System to Stop Autoimmunity
Previously other groups have used tattoo gun-based mechanisms to stimulate immune responses based on the theoretical advantage that a high number of microinjections results in a greater number of antigen presenting cells received to target immunogens.
“Utilizing a “tattoo gun” approach evokes a substantial degree of inflammation, which is classically believed to stimulate immunity. Surprisingly we found that in the presence of inhibitors of dendritic cell maturation factors that this approach led to potent generation of “suppressive” immune cells,” said
“The quest to replicate the biological condition of pregnancy in which immunologically distinct tissues are not rejected by the host has been the Holy Grail of immunologists for the past century,” said Dr.
The concept of modulating antigen presentation to inhibit pathological immunity has previously been described. However, the unexpected potency of the large surface area of injection only achievable by a tattoo gun was completely unexpected. Furthermore, the finding that dermal transfection of the AIRE gene, as well as the FoxP3 gene was able to dampen autoimmune pathology and was completely unexpected.
“While we are highly focused on execution of our Phase III COVID clinical trial, through our multiple collaborations we discover multiple unexpected findings on a regular basis,” said
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