UCB presents latest thymidine kinase 2 deficiency (TK2d) research at the United Mitochondrial Disease Foundation (UMDF) 2025 Conference

Rhea-AI Summary

UCB announced its participation in the UMDF Mitochondrial Medicine 2025 Conference, presenting three key research posters on thymidine kinase 2 deficiency (TK2d). The presentations include findings from disease course studies in untreated patients, examining progression and outcomes over time, as well as insights into caregiver burden from the Assessment of TK2d Patient Perspectives study. The research focuses on both pediatric (≤12 years) and adult (>12 years) onset patients, representing data from the largest international TK2d dataset. Dr. Kimberly A. Moran, SVP & Head of US Rare Diseases at UCB, emphasized the company's commitment to advancing understanding of this rare mitochondrial disease, which has historically lacked research attention.

• UCB will contribute three presentations, including data on the disease course of thymidine kinase 2 deficiency (TK2d) in untreated patients and insights into caregiver impact
• These data emphasize UCB's commitment to advancing treatment outcomes and patient experiences in TK2d and uncovering important insights into this rare disease

ATLANTA, June 20, 2025 /PRNewswire/ -- UCB, a global biopharmaceutical company, announced it will present pioneering TK2d research at the UMDF Mitochondrial Medicine 2025 Conference taking place June 18-21, 2025, in St. Louis, Missouri.

UCB will present findings from disease course studies of TK2d in untreated patients, looking at disease progression and outcomes over time,^1,2 as well as real-world insights into the burden and impact on caregivers, providing a comprehensive view of the experiences and challenges faced by those supporting individuals with TK2d.³

"Our participation in the UMDF 2025 Conference underscores our commitment to advancing the understanding of TK2d, an area previously lacking in research," said Kimberly A. Moran, PhD, MBA, SVP & Head, US Rare Diseases. "We are excited to introduce new findings that have the potential to impact people living with this rare mitochondrial disease."

UCB presentations at UMDF 2025

Lead author	Title	Presentation details
M Hirano et al.	The Disease Course of Untreated Patients with Thymidine Kinase 2 Deficiency (TK2d) Aged ≤12 Years at TK2d Symptom Onset: Findings from the Largest International TK2d Dataset	Poster
M Hirano et al.	The Disease Course of Untreated Patients with Thymidine Kinase 2 Deficiency (TK2d) Aged >12 Years at TK2d Symptom Onset: Findings from the Largest International TK2d Dataset	Poster
A Karaa et al.	Burden and impact of caring for those with thymidine kinase 2 deficiency (TK2d): results from the Assessment of TK2d Patient Perspectives (ATP) study	Poster

For further information, contact UCB:

Rare Disease Communications
Daphne Teo
T +1 (770) 880-7655
daphne.teo@ucb.com  

Global Communications
Nick Francis
T +44 7769 307745
nick.francis@ucb.com 

Corporate Communications, Media Relations
Laurent Schots
T +32.2.559.92.64
laurent.schots@ucb.com

Investor Relations
Antje Witte   
T +32.2.559.94.14
antje.witte@ucb.com

About UCB
UCB, Brussels, Belgium (www.ucb.com) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With approximately 9000 people in approximately 40 countries, the company generated revenue of € 6.15 billion in 2024. UCB is listed on Euronext Brussels (symbol: UCB). Follow us on Twitter: @UCB_news.

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References:

1. Hirano, M., et al. The Disease Course of Untreated Patients with Thymidine Kinase 2 Deficiency (TK2d) Aged ≤12 Years at TK2d Symptom Onset: Findings from the Largest International TK2d Dataset.
2. Hirano, M., et al. The Disease Course of Untreated Patients with Thymidine Kinase 2 Deficiency (TK2d) Aged >12 Years at TK2d Symptom Onset: Findings from the Largest International TK2d Dataset.
3. Karaa, A., et al. Burden and impact of caring for those with thymidine kinase 2 deficiency (TK2d): results from the Assessment of TK2d Patient Perspectives (ATP) study.

©2025 UCB, Inc., Smyrna, GA 30080. All rights reserved. US-MT-2500121

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FAQ

What research is UCB presenting at the UMDF 2025 Conference?

UCB is presenting three posters: two on disease course studies in untreated TK2d patients (for ages ≤12 and >12 years), and one on caregiver burden from the ATP study.

When and where is the UMDF Mitochondrial Medicine 2025 Conference taking place?

The conference is taking place from June 18-21, 2025, in St. Louis, Missouri.

What is the significance of UCB's TK2d research presentations?

The research represents findings from the largest international TK2d dataset, providing important insights into disease progression and caregiver experiences in an area that previously lacked research.

Who is leading the TK2d research presentations at UMDF 2025?

The disease course studies are led by M Hirano et al., while the caregiver burden study is led by A Karaa et al.

What is UCB's (UCBJY) focus regarding TK2d research?

UCB is focused on advancing the understanding of TK2d through research on disease progression, outcomes over time, and real-world insights into caregiver challenges and experiences.