VivoSim to Debut Antibody Drug Conjugate Data, representing a major new market for NAMkind models, at Society of Toxicology Meeting in San Diego
Rhea-AI Summary
VivoSim (Nasdaq: VIVS) will present validation data for its NAMkind™ liver and NAMkind™ intestine models at the Society of Toxicology meeting in San Diego, March 22-25, 2026. Testing versus marketed antibody drug conjugates (ADCs) reportedly shows close correlation with clinical liver toxicity and intestinal side effects (diarrhea).
VivoSim says these human 3D models can reveal target engagement, premature linker cleavage, and bystander effects, and its NAMkind toxicology services are available in the US, Europe, Korea and China as capacity scales.
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Key Figures
Market Reality Check
Peers on Argus
VIVS is down 1.54% while peers show mixed moves (e.g., CYCCP -5.61%, PCSA +1.30%, MTNB +0.48%, EPIX +0.60%). With no peers in the momentum scanner and no same-day peer news, trading appears more stock-specific than sector-driven.
Historical Context
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Jan 29 | Distribution expansion | Positive | -1.7% | New Korea and China distributors for NAMkind liver and intestine services. |
| Jan 06 | Leadership hire | Positive | +4.6% | Appointment of experienced Chief Scientific Officer to lead NAM strategy. |
| Aug 14 | Leadership hire | Positive | -3.2% | Chief Commercial Officer hired to scale NAMkind toxicology services. |
Recent company-building news often saw muted or negative next-day moves, with one leadership appointment aligning positively and two commercial/leadership updates selling off.
This announcement showcases new NAMkind™ data for antibody drug conjugate toxicity, extending VivoSim’s focus on human-relevant toxicology tools. Recent history highlights commercial expansion into Asia-Pacific distributors for liver and intestine NAMkind™ services (Jan 29, 2026), and leadership strengthening with the appointment of a new Chief Scientific Officer (Jan 6, 2026) and Chief Commercial Officer (Aug 14, 2025). Despite these generally positive milestones, prior news sometimes coincided with share-price declines, suggesting a pattern where favorable updates have not consistently translated into sustained market strength.
Market Pulse Summary
This announcement emphasizes new NAMkind™ liver and intestine data that track closely with clinical toxicity outcomes for antibody drug conjugates, reinforcing VivoSim’s positioning in human-relevant preclinical safety testing. Recent news has featured global distributor expansion and senior scientific hiring, while filings documented ongoing net losses and liquidity constraints. Investors monitoring this story may focus on how well ADC-related NAMkind™ demand translates into revenue growth and whether operating trends ease concerns noted in prior SEC reports.
Key Terms
antibody drug conjugates medical
New Approach Methodologies (NAMs) regulatory
AI-generated analysis. Not financial advice.
Company produces thorough reference testing on Antibody Drug Conjugates, showing high correlation with clinical liver and intestinal toxicity and side effects
SAN DIEGO, Feb. 11, 2026 (GLOBE NEWSWIRE) -- VivoSim Labs, Inc. (Nasdaq: VIVS) (the “Company” or “VivoSim”), a provider of next-generation New Approach Methodologies (NAMs) for preclinical safety, today announced it will attend the Society of Toxicology (“SOT”) meeting in San Diego, CA that takes place March 22-25 and present new data on its NAMkind™ liver and NAMkind™ Intestine model, including data on validating the models for use in predicting toxicity and side effect profiles of antibody drug conjugates (ADCs).
Considering the hundreds of ADCs in development across the globe, the potential for off target toxicity due to their common use in oncology to deliver cytotoxic payloads, and a lack of current available scientific solutions to separate anticancer activity from unwanted cytotoxicity, the use of NAMkind™ models becomes a powerful tool to use in conjunction with existing methods to select and improve the best ADC candidates for drug development.
VivoSim NAMkind™ models can reveal details of target engagement in organ tissues, premature linker cleavage, bystander effects and more in complex human cell models that replicate much of the target tissue biology in a controlled experimental setting.
Testing of approved ADC therapies in NAMkind™ models shows close correlation with clinical results
NAMkind™ models have now been tested against a wide set of marketed ADC molecules, showing close correlation with clinical results in terms of the toxic impact in the liver and side effect profile in the intestine (causing diarrhea). These results will be presented for the first time at SOT in San Diego.
“These ADC toxicity results show a close correlation to clinical safety outcomes,” said Amar Sethi, Chief Scientific Officer at VivoSim. “We think that our partners working with our testing models will be able to screen out toxicities during lead candidate optimization, resulting in greater success in the clinic at eliminating cancers using drugs with limited side effect profiles,” he continued.
“VivoSim’s scientific leadership in the field of human-relevant NAM models with results that translate to the clinic is bolstered by these new data,” said Keith Murphy, VivoSim’s Executive Chairman. “Our ability to demonstrate results that match known clinical results of cutting-edge drug modalities confirms that our 3D human cell models have a strong ability to faithfully reproduce the complex biology of human tissues.”
NAMKind™ liver and small intestine toxicology services are now available in US, Europe, and via local distributor engagement across Korea and China, with VivoSim continuing to scale capacity to support expanding global demand and urgent, real-world development needs.
About VivoSim Labs
VivoSim Labs, Inc. (“VivoSim” and the “Company”), is a pharmaceutical and biotechnology services company that is focused on providing testing of drugs and drug candidates in three-dimensional (“3D”) human tissue models of liver and intestine. The Company offers partners liver and intestinal toxicology insights using its new approach methodologies (“NAM”) models. The Company anticipates accelerated adoption of human tissue models following the U.S. Food and Drug Administration (“FDA”) announcement on April 10, 2025 to refine animal testing requirements in favor of these non-animal NAM methods. VivoSim Labs operates from San Diego, CA. Visit www.vivosim.ai.
Forward-Looking Statements
Any statements contained in this press release that do not describe historical facts constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. Any forward-looking statements contained herein are based on current expectations but are subject to a number of risks and uncertainties. Forward-looking statements include statements regarding NAMKind™, including target turnaround time and its potential to help users de-risk their pipelines, avoid costly downstream failures, reduce rework, prioritize the right assets, move faster, save millions and reduce risk; VivoSim’s commercial presence across Asia-Pacific; the evaluation and acceptance of scientifically robust NAM-based evidence; the Company’s ability to capture growing demand in the in vitro toxicology testing market; demand for human-relevant toxicology; the market opportunity and market size of gastrointestinal in vitro models and toxicology services; and the Company’s scaling capacity to support expanding global demand and development needs. Such forward-looking statements are not guarantees of performance and actual actions or events could differ materially from those contained in such statements. These risks and uncertainties and other factors are identified and described in more detail in the Company’s filings with the SEC, including its Annual Report on Form 10-K filed with the SEC on June 5, 2025, as such risk factors are updated in its most recently filed Quarterly Report on Form 10-Q filed with the SEC on November 6, 2025. You should not place undue reliance on these forward-looking statements, which speak only as of the date that they were made. These cautionary statements should be considered with any written or oral forward-looking statements that the Company may issue in the future. Except as required by applicable law, including the securities laws of the United States, the Company does not intend to update any of the forward-looking statements to conform these statements to reflect actual results, later events, or circumstances or to reflect the occurrence of unanticipated events.
Contact(s):
Investor Relations
info@vivosim.ai
VivoSim Labs, Inc.
FAQ
What data will VivoSim (VIVS) present at the Society of Toxicology meeting March 22-25, 2026?
How do VivoSim NAMkind™ models predict antibody drug conjugate (ADC) toxicity for VIVS?
Will VivoSim’s NAMkind™ liver and intestine services be available globally for VIVS partners?
What clinical endpoints did VivoSim (VIVS) validate with NAMkind™ ADC testing?
How might VIVS partners use NAMkind™ results during ADC lead optimization?
