Volition Announces Detection of Over 95% of Early-Stage Cancers
Rhea-AI Summary
Volition (NYSE AMERICAN: VNRX) reported blinded validation results from 81 subjects showing strong detection performance using its Capture-Seq™ liquid biopsy for colorectal and lung cancer.
The cohort achieved ~95% detection for stage I and II cancers (I: 94% [17/18]; II: 96% [26/27]), overall sensitivity 93% (55/59) and specificity 95% (21/22). The company cites a combined $36 billion TAM ($23B MCED; $13B MRD) and says it is in active discussions with potential licensing partners to commercialize the technology.
Positive
- Stage I detection of 94% (17/18)
- Stage II detection of 96% (26/27)
- 95% specificity in healthy controls (21/22)
Negative
- Blinded validation cohort size is small: 81 subjects
- Overall sensitivity 93% (55/59) — below some early-stage claims
- Results are preliminary and require validation in larger cohorts
News Market Reaction – VNRX
In the Mar 25 session, VNRX declined 4.87%, reflecting a moderate negative market reaction. Argus tracked a peak move of +32.7% during that session. Argus tracked a trough of -15.9% from its starting point during tracking. Our momentum scanner triggered 26 alerts that day, indicating elevated trading interest and price volatility. Trading volume was exceptionally heavy at 6.1x the daily average, suggesting significant selling pressure.
Data tracked by StockTitan Argus on the day of publication.
Key Figures
Historical Context
| Date | Event | Sentiment | 24h Move | Catalyst |
|---|---|---|---|---|
| Mar 18 | Capture‑Seq data | Positive | +5.3% | Reported >99% pure ctDNA via Capture‑Seq and strong blinded cohort detection. |
| Mar 06 | Vet test launch | Positive | +0.7% | Automated Nu.Q® Vet Cancer Test rollout with Fujifilm Vet Systems in Japan. |
| Feb 25 | Commercial update | Positive | +25.6% | Multi‑pillar progress, Capture‑Seq TAM update, sepsis program and CE‑marked products. |
| Feb 10 | Distribution deal | Positive | -3.0% | New Nu.Q® Discover distributor in Japan with growing client base and TAM. |
| Feb 09 | Listing notice | Negative | -3.0% | NYSE American non‑compliance notice on stockholders’ equity and potential delisting risk. |
24h Move is the share-price change in the day after each event; other market factors may also have contributed.
Positive commercial and clinical news has often coincided with favorable next-day moves, though not uniformly, while clearly negative regulatory news aligned with declines.
In the last few months, Volition has repeatedly highlighted its epigenetics and liquid biopsy platform, including Capture‑Seq™, commercial progress in veterinary diagnostics, and broader multi‑pillar execution. Notable items include a reported world‑first Capture‑Seq™ purity achievement on Mar 18, 2026, growing Nu.Q® Vet adoption in Japan, and strategic distribution and reimbursement milestones. Against this backdrop, the latest early‑stage cancer detection data further extends the Capture‑Seq™ narrative within an already active news flow.
Key Terms
liquid biopsy medical
capture-seq™ medical
circulating tumor dna medical
ctdna medical
cell free nucleoproteins medical
minimal residual disease medical
multi-cancer early detection medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
- Blinded validation cohort achieves over
95% sensitivity for stage I & II cancers with95% specificity - Capture-Seq™ Targets
$36 Billion
Dr. Jake Micallef, Chief Scientific Officer, Volition, commented:
"As we reported previously, Volition has developed a new liquid biopsy method, Capture-Seq™, which enriches and purifies plasma samples resulting in virtually pure circulating tumor DNA (ctDNA) samples for analysis.
"We are now releasing the data from a blinded validation cohort of 81 subjects (colorectal and lung cancer patients = 59, healthy controls = 22) and are extremely encouraged by the results, particularly in early-stage cancer detection.
Details are summarized in the table below1:
Cancer Stage | Detection Rate |
I | |
II | |
III | |
IV | |
Unknown | |
All Stages | Sensitivity= |
Controls | Specificity= |
"Volition is, I believe, the first liquid biopsy company to focus on circulating cell free nucleoproteins and we have filed a number of new patents to protect this technology."
Dr. Andrew Retter, Medical Consultant, Volition, commented:
"From a clinical perspective, the proof of concept and early blinded validation results are extremely encouraging, and the early-stage cancer detection of
"For patients, the potential significance is huge. If validated in larger cohorts, CTCF Capture-Seq™ could contribute to Multi-Cancer Early Detection (MCED) fulfilling a significant unmet clinical need.
"We also believe Capture-Seq™ has the potential to play a role in cancer management, including but not limited to, Minimal Residual Disease detection and treatment monitoring, either alone or potentially in combination with other technologies too."
Mr. Gael Forterre, Chief Commercial Officer, Volition, added:
"This scientific breakthrough has generated a lot of interest with potential licensing partners, and we are excited to share this early-stage detection data.
"We feel that this technology could, with further development, become very widely used, in both the human and veterinary markets, and fits very well with our Nu.Q® product portfolio.
"We believe this represents a significant commercial opportunity with a Total Addressable Market on an annualized basis of approximately
"We are in active discussions with several large liquid biopsy and diagnostic companies to accelerate the development and launch of this technology as soon as possible."
About Capture-Seq™
The biggest problem facing liquid biopsy worldwide is that the vast majority of circulating DNA in blood plasma samples comes from healthy cells, not cancer cells. In a world first new technology, Volition has overcome this hurdle and produced >
In a recently submitted manuscript we report a new, two-step method for preparing pure circulating tumor DNA data sets for cancer patients:
- physical enrichment of the sample and
- bioinformatic removal of virtually all remaining non-tumor cfDNA sequences from the DNA sequence data set.
This new method produced >
These methodological and technological breakthroughs represent a novel liquid biopsy method for a novel class of potentially thousands of liquid biopsy sequence biomarkers.
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- Data on File
- Data on File: Volition TAM Model
About Volition
Volition is a multi-national company focused on advancing the science of epigenetics. Volition is dedicated to saving lives and improving outcomes for people and animals with life-altering diseases through earlier detection, as well as disease and treatment monitoring.
Through its subsidiaries, Volition is developing and commercializing simple, easy to use, cost-effective blood tests to help detect and monitor a range of diseases, including some cancers and diseases associated with NETosis, such as sepsis. Early detection and monitoring have the potential not only to prolong the life of patients, but also to improve their quality of life.
Volition's research and development activities are centered in
The contents found at Volition's website address are not incorporated by reference into this document and should not be considered part of this document. Such website address is included in this document as an inactive textual reference only.
Media Enquiries: Louise Batchelor, Volition, mediarelations@volition.com,+44 (0)7557 774620
Safe Harbor Statement
Statements in this press release or associated video or link may be "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, that concern matters that involve risks and uncertainties that could cause actual results to differ materially from those anticipated or projected in the forward-looking statements. Words such as "expects," "anticipates," "intends," "plans," "aims," "targets," "believes," "seeks," "estimates," "optimizing," "potential," "goal," "suggests," "could," "would," "should," "may," "will" and similar expressions identify forward-looking statements. These forward-looking statements relate to, among other topics, Volition's expectations related to revenue opportunities and growth, the effectiveness and availability of Volition's blood-based diagnostic, prognostic and disease monitoring tests, Volition's ability to develop and successfully commercialize such test platforms for early detection of cancer and other diseases as well as serving as a diagnostic, prognostic or disease monitoring tools for such diseases, Volition's expectations regarding future publications, Volition's success in securing licensing and/or distribution agreements with third parties for its products, and Volition's expectations regarding the terms of such agreements. Volition's actual results may differ materially from those indicated in these forward-looking statements due to numerous risks and uncertainties, including, without limitation, results of studies testing the efficacy of its tests. For instance, if Volition fails to develop and commercialize diagnostic, prognostic or disease monitoring products, it may be unable to execute its plan of operations. Other risks and uncertainties include Volition's failure to obtain necessary regulatory clearances or approvals to distribute and market future products; a failure by the marketplace to accept the products in Volition's development pipeline or any other diagnostic, prognostic or disease monitoring products Volition might develop; Volition's failure to secure adequate intellectual property protection; Volition will face fierce competition and Volition's intended products may become obsolete due to the highly competitive nature of the diagnostics and disease monitoring market and its rapid technological change; downturns in domestic and foreign economies; and other risks, including those identified in Volition's most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q, as well as other documents that Volition files with the Securities and Exchange Commission. These statements are based on current expectations, estimates and projections about Volition's business based, in part, on assumptions made by management. These statements are not guarantees of future performance and involve risks, uncertainties and assumptions that are difficult to predict. Forward-looking statements are made as of the date of this release, and, except as required by law, Volition does not undertake an obligation to update its forward-looking statements to reflect future events or circumstances.
Nucleosomics™, Capture-PCR™, Capture-Seq™ and Nu.Q® and their respective logos are trademarks and/or service marks of VolitionRx Limited and its subsidiaries. All other trademarks, service marks and trade names referred to in this press release or associated video or link are the property of their respective owners. Additionally, unless otherwise specified, all references to "$" refer to the legal currency of
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SOURCE VolitionRx Limited