VolitionRx Shares Further Details and Video of the DETECSEPS Program Launch in France
VolitionRx’s Nu.Q NETs H3.1 biomarker will be evaluated in a 1,000‑patient, €6.3 million French consortium program for early sepsis detection.
Rhea-AI Summary
VolitionRx (VNRX) highlighted further details of the DETECSEPS sepsis early‑detection program in France, in which it is an industry partner supplying its Nu.Q® NETs H3.1 blood biomarker. The government‑funded consortium has been awarded €6.3 million (~7.3 million) and will evaluate the approach in 1,000 patients presenting to emergency departments with suspected infection.
DETECSEPS combines the NEWS2 clinical score, Volition’s Nu.Q® NETs H3.1 assay to quantify NETosis, and IDS France’s i10 automated device to generate rapid results and help distinguish patients needing hospital care from those who can be safely sent home. The clinical trials are sponsored and coordinated by AP‑HP with Hospices Civils de Lyon, IHU Sepsis and IDS France as partners. Volition is providing the Nu.Q® H3.1 assay pro bono to enable this evaluation.
Positive
- Government funding of €6.3 million (~7.3 million) for DETECSEPS
- Program to assess Volition’s Nu.Q® NETs H3.1 in 1,000 emergency patients
- Volition designated as sole biomarker provider for DETECSEPS
- Assay supplied pro bono, lowering upfront deployment cost for the consortium
Negative
- None.
Key Figures
- Government funding
- €6.3 million
- DETECSEPS program
- Evaluation size
- 1,000 patients
- Real-life care settings
Historical Context
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Expected DETECSEPS recruitment and reported Nu.Q NETs sepsis validation progress
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Peer-reviewed Nu.Q NETs data linked biomarker levels with sepsis severity and outcomes
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Key Terms
netosis medical
national early warning score medical
pharmacogenetics medical
nucleosome biomarkers medical
AI-generated analysis. How Rhea-AI works. Not financial advice.
DETECSEPS aligns with Volition's core purpose – to revolutionize the diagnosis and monitoring of life-altering diseases such as sepsis.
Sepsis is a dysregulated response of the body to an infection, responsible for the failure of one or more organs and which can quickly become life-threatening. Worldwide, it is estimated that this pathology is responsible for 21 million deaths per year1. Rapid detection is therefore crucial to improve care and reduce mortality.
Cameron Reynolds, Chief Executive Officer, Volition, commented:
"I believe this is an exceptional vote of confidence in our Nu.Q® NETs platform. We are honored to be part of the DETECSEPS Consortium and to celebrate the major milestone of the program's official launch."
The DETECSEPS program aims to identify on arrival into the Emergency Department which patients with suspected infection are at risk of developing sepsis and require hospital care and which patients can be safely redirected home.
The objective is to allow earlier care and a more accurate referral of each patient.
Initiated by the IHU Sepsis, directed by Professor Djillali Annane of the Raymond-Poincaré Hospital AP-HP, DETECSEPS brings together within the same consortium the AP-HP, the project's coordinating institution and sponsor of the clinical trials, the Hospices Civils de
The strategy is based on an innovative combination:
- The National Early Warning Score (NEWS) 2 clinical score to quickly assess the patient's condition upon arrival at the emergency department.
- Volition's blood biomarker Nu.Q® NETs H3.1, capable of quantifying NETosis, an immune mechanism linked to sepsis.
- The i10 device from IDS to automate the Volition biomarker for a quick and accurate result.
With government funding of
Prof. Marion Douplat, Head of the Emergency Department at Lyon Sud Hospital – HCL commented:
"Sepsis remains one of the main medical emergencies we face on a daily basis. Every hour saved in its identification can have a major impact on patients' prognosis.
"With DETECSEPS, we want to take a new step forward by combining the clinical evaluation carried out on arrival in the emergency room with an innovative biomarker, Nu.Q® NETs H3.1, that will make it possible to identify patients at risk earlier.
"This project perfectly illustrates the strength of translational research: to bring out innovations resulting from research to integrate them quickly into care pathways."
Prof. Léa Payen-Gay, Laboratory of Pharmacology, Toxicology and Pharmacogenetics, Department of Multisite Biochemistry and Molecular Biology (LBMMS) – HCL added:
"The collaboration between the Hospices Civils de
"This collaboration has gradually extended to the study of NETosis and sepsis, with the ambition of validating innovative biomarkers in real healthcare conditions.
"In particular, it provides for the integration of the test on the local biochemistry platforms of the HCL's multi-site Medical Biology Laboratory, in order to evaluate its analytical performance, robustness and clinical applicability.
"It now constitutes a major scientific, technological and human basis for the DETECSEPS project, which evaluates the biomarker Nu.Q® NETs H3.1 in the emergency departments of the HCL and the AP-HP, with the aim of improving the early detection of sepsis and patient care."
Mr. Ed Combes, Managing Director – IDS France said:
"We are honored to be part of this consortium of excellence alongside HCL, AP-HP, IHU SEPSIS and Volition.
"The IDS i10 instrument, designed and manufactured in
"The elements are in place for a significant contribution to improving the early detection of sepsis."
- Gray, Authia P et al. Global, regional, and national sepsis incidence and mortality, 1990–2021: a systemic analysis. The Lancet Global Health, 2025; 13(12): e2013-e2026. doi: 10.1016/s2214-109x(25)00356-0
About the Consortium
The DETECSEPS project was winner of the "Challenge Prevention" call for proposals launched by the French Health Innovation Agency and operated by the Banque Publique d'Investissement, as part of the
Initiated by the IHU Sepsis, led by Prof. Djillali Annane of the Raymond-Poincaré Hospital AP-HP, DETECSEPS brings together within the same consortium the AP-HP, the project's coordinating institution and sponsor of the clinical trials, the Hospices Civils de
For this project, the AP-HP is mobilizing several care services and research teams contributing to the management of sepsis. The DETECSEPS project will more specifically mobilize the emergency departments of the Bichat-Claude-Bernard and Ambroise Paré AP-HP hospitals, as well as the reference medical biology laboratories of these two sites, which contribute to the National Reference Centers (CNR) in the fight against infectious diseases. The AP-HP also provides methodological support and biostatistical analysis for the project (Department of Biostatistics of the Saint-Louis Hospital AP-HP, URC Saint Louis), medico-economic (URCEco, Hôtel-Dieu AP-HP) and public health (Public Health Department of the Raymond-Poincaré Hospital AP-HP).
As industry partners, Volition will provide the sole biomarker, Nu.Q® NETs H3.1 and IDS France, part of Revvity, will provide the Immunodiagnostic Systems (IDS) i10® automated analyzer.
About Volition
Volition is a multi-national company focused on advancing the science of epigenetics. Volition is dedicated to saving lives and improving outcomes for people and animals with life-altering diseases through earlier detection, as well as disease and treatment monitoring.
Through its subsidiaries, Volition is developing and commercializing simple, easy to use, cost-effective blood tests to help detect and monitor a range of diseases, including some cancers and diseases associated with NETosis, such as sepsis. Early detection and monitoring have the potential not only to prolong the life of patients, but also to improve their quality of life.
Volition is providing the Nu.Q® H3.1 Assay pro-bono to enable this important evaluation.
The contents found at Volition's website address are not incorporated by reference into this document and should not be considered part of this document. Such website address is included in this document as an inactive textual reference only.
Media Enquiries:
Louise Batchelor, Volition, mediarelations@volition.com, +44 (0)7557 774620
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FAQ
AI-generated questions and answers. How Rhea-AI works. Not financial advice.
What is the primary goal of the DETECSEPS program?
The DETECSEPS program aims to identify, upon arrival in the emergency department, which patients with suspected infection are at risk of developing sepsis and require hospital care and which patients can be safely redirected home, with the objective of earlier care and more accurate referral of each patient.
Which organizations are participating in the DETECSEPS consortium?
The consortium was initiated by IHU Sepsis and brings together AP‑HP (the coordinating institution and clinical trial sponsor), Hospices Civils de Lyon, and industrial partners IDS France and Volition. Several AP‑HP emergency departments, reference medical biology laboratories, and biostatistics, medico‑economic and public health teams are mobilized for the project.
How will Volition’s Nu.Q NETs H3.1 biomarker be used in DETECSEPS?
Volition’s Nu.Q® NETs H3.1 blood biomarker will be integrated into local biochemistry platforms and evaluated on the IDS i10 automated analyzer to quantify NETosis in patients with suspected infection, as part of a strategy that combines clinical scoring (NEWS2) with biomarker testing to improve early detection of sepsis and patient triage.
Where will the DETECSEPS clinical evaluation be conducted?
The evaluation will take place in real‑life care settings, including the emergency departments of the Bichat‑Claude‑Bernard and Ambroise Paré AP‑HP hospitals and the emergency departments of Hospices Civils de Lyon, supported by their reference medical biology laboratories.