Xenon Pharmaceut Stock Price, News & Analysis

Xenon Pharmaceuticals Inc. (Nasdaq:XENE) has successfully closed an underwritten public offering of 5,135,135 common shares, including an additional 810,810 shares from the underwriters' exercised option. The shares were priced at $18.50 each, while pre-funded warrants to purchase 1,081,081 common shares were offered at $18.4999. The total gross proceeds from the offering are approximately $115.0 million, before deductions. Jefferies, Stifel, and William Blair acted as joint book-running managers for the offering.

Xenon Pharmaceuticals Inc. (Nasdaq:XENE) announced a public offering of 4,324,325 common shares priced at $18.50 each, alongside pre-funded warrants for 1,081,081 common shares at $18.4999. The offering aims to raise approximately $100 million before deductions. An additional option for underwriters to purchase 810,810 shares exists for 30 days. The offering is anticipated to close around March 12, 2021, subject to standard conditions. Jefferies, Stifel, and William Blair are leading the offering, with further details available through their channels.

Xenon Pharmaceuticals (Nasdaq:XENE) has initiated an underwritten public offering of its common shares, including pre-funded warrants for select investors. The offering is made under its existing shelf registration statement, with underwriters given a 30-day option to purchase an additional 15% of the shares offered. The transaction, led by Jefferies, Stifel, and William Blair, is subject to market conditions and may not be completed as anticipated. No shares will be sold in Canada, and a preliminary prospectus will be filed with the SEC.

Xenon Pharmaceuticals has announced the acceptance of its Investigational New Drug (IND) application by the U.S. FDA and IRB approval for a Phase 2 clinical trial of XEN1101, aimed at treating major depressive disorder (MDD) and anhedonia. The trial will be conducted in collaboration with the Icahn School of Medicine at Mount Sinai, with Dr. James W. Murrough as the principal investigator. This study will evaluate the antidepressant effects of XEN1101, utilizing a randomized, double-blind, placebo-controlled design involving approximately 60 patients, expected to start in Q2 2021.

Xenon Pharmaceuticals Inc. (Nasdaq:XENE) provided its financial results for 2020 and updates on its clinical trials. The company anticipates topline data from the Phase 2b ‘X-TOLE’ clinical trial for XEN1101 in adult focal epilepsy by Q3 2021, highlighting efficacy and safety. Total revenue rose to $32.2 million in 2020, driven by $26.8 million of deferred revenue. However, R&D expenses increased to $50.5 million. The net loss was reduced to $28.8 million compared to $41.6 million in 2019. Xenon has sufficient cash to fund operations into 2023, bolstered by partnerships.

Xenon Pharmaceuticals Inc. (Nasdaq:XENE) will report its 2020 financial results on March 1, 2021, after U.S. market close. A conference call and webcast will follow at 4:30 PM ET to discuss these results and provide a corporate update. Additionally, Xenon will participate in the SVB Leerink 10th Annual Global Healthcare Conference on February 24, 2021, at 10:00 AM ET, which will be webcast live.

Xenon is focused on developing innovative therapeutics for neurological disorders, particularly epilepsy.

Xenon Pharmaceuticals (XENE) presented promising pre-clinical and clinical data on XEN1101, a Kv7 potassium channel modulator, at ASENT 2021. The ongoing Phase 2b X-TOLE clinical trial shows XEN1101 is effective as adjunctive treatment for adult patients with focal epilepsy, with results expected in Q3 2021. New data suggest potential efficacy for mood disorders like depression and anhedonia. Initial results indicate XEN1101 may be well-tolerated, with positive pre-clinical evidence supporting its use in combinations with other medications.

Xenon Pharmaceuticals announces a leadership transition planned for June 2021, with Simon Pimstone stepping down as CEO to become Executive Chair, while Ian Mortimer will take over as CEO. The company anticipates key milestones in 2021, including topline data from the XEN1101 Phase 2b X-TOLE trial for adult focal epilepsy, expected in Q3 2021, and the initiation of the Phase 3 EPIK trial for XEN496 in pediatric KCNQ2-DEE. The press release highlights the company's commitment to developing innovative treatments for neurological disorders.

Xenon Pharmaceuticals announced promising interim data on XEN007 from a Phase 2 study for treating Childhood Absence Epilepsy (CAE). All three patients demonstrated over a 50% reduction in seizures, with two achieving over 80% reduction. The study is well tolerated with no serious adverse events reported. Future enrollment will focus solely on CAE, given these favorable results. Xenon continues to advance its pipeline, including XEN1101 and XEN496, with presentations scheduled at AES2020.