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Xilio Therapeutics, Inc. - $XLO STOCK NEWS

Welcome to our dedicated page for Xilio Therapeutics news (Ticker: $XLO), a resource for investors and traders seeking the latest updates and insights on Xilio Therapeutics stock.

Our selection of high-quality news articles is accompanied by an expert summary from Rhea-AI, detailing the impact and sentiment surrounding the news at the time of release, providing a deeper understanding of how each news could potentially affect Xilio Therapeutics's stock performance. The page also features a concise end-of-day stock performance summary, highlighting the actual market reaction to each news event. The list of tags makes it easy to classify and navigate through different types of news, whether you're interested in earnings reports, stock offerings, stock splits, clinical trials, fda approvals, dividends or buybacks.

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Rhea-AI Summary

Xilio Therapeutics (NASDAQ: XLO) announced significant pipeline and business updates alongside its Q1 2024 financial results. Highlighting their progress, they plan to initiate a Phase 2 trial for XTX101, an Fc-enhanced anti-CTLA-4, in combination with atezolizumab for MSS CRC in Q3 2024, and report clinical data in Q4 2024. The XTX301 IL-12 program, partnered with Gilead Sciences, received $43.5M upfront and is set for Phase 1 data release in Q4 2024. Furthermore, Xilio's research efforts on bispecifics and immune cell engagers are advancing. Financially, Xilio ended Q1 2024 with $34M in cash, supplemented by an additional $44.6M from Gilead agreements and private placements, projecting a cash runway until Q2 2025.

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Xilio Therapeutics, Inc. announces progress in pipeline development, business updates, and financial results. The company plans to initiate Phase 2 trial for XTX101 in combination with atezolizumab in patients with MSS CRC. Xilio granted Gilead exclusive license for XTX301, expecting cash runway into Q2 2025.
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Xilio Therapeutics, Inc. announces strategic portfolio reprioritization to focus on clinical-stage programs for XTX301 and XTX101, additional Phase 2 data for XTX202, and a private placement with gross proceeds of $11.3 million. The company also entered into an exclusive license agreement with Gilead Sciences, Inc., anticipating up to $604.0 million in additional contingent payments.
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Gilead Sciences, Inc. and Xilio Therapeutics, Inc. have entered into an exclusive license agreement for Xilio's Phase 1 tumor-activated IL-12 program, XTX301, to treat various cancers. XTX301 is currently in a Phase 1 trial for advanced solid tumors. The agreement includes upfront payments of $43.5 million, potential additional payments of up to $604.0 million, and royalties on global sales. Gilead may transition to lead development after specified clinical data delivery, with a $75 million fee. However, the transaction is expected to reduce Gilead's 2024 EPS by $0.03 - $0.04.
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Xilio Therapeutics, Inc. announced René Russo's participation in the 'Novel Immuno-Oncology' panel discussion at the TD Cowen 44th Annual Health Care Conference. The event will take place on March 4, 2024, at 10:30 am EST, with a live webcast available on the company's website.
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Xilio Therapeutics, Inc. announced that René Russo, Pharm.D., president and chief executive officer, will participate in a fireside chat at the Guggenheim 6th Annual Biotechnology Conference on February 7, 2024. The company focuses on discovering and developing tumor-activated immuno-oncology therapies for cancer patients. The event will be live webcasted and accessible through the company's website, with a replay available for 30 days.
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Xilio Therapeutics, Inc. (Nasdaq: XLO) is a clinical-stage biotechnology company reporting encouraging preliminary safety data from the first three dose levels of XTX301, a tumor-activated IL-12, in patients with advanced solid tumors. The company has also initiated patient dosing in Phase 1/2 trial for XTX101 and plans to report Phase 2 trial data for XTX202 by the end of the first quarter of 2024.
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Xilio Therapeutics, Inc. (XLO) announced the initiation of enrollment for its Phase 1 clinical trial of XTX101, an investigational tumor-activated, Fc-enhanced anti-CTLA-4, in combination with atezolizumab and reported updated monotherapy data from its ongoing Phase 1 clinical trial evaluating XTX101 in late-line patients with advanced and immuno-oncology (IO) refractory solid tumors. The data were presented at the European Society for Medical Oncology (ESMO) Immuno-Oncology Congress on December 7, 2023. The Phase 1 combination dose escalation is expected to support a planned Phase 2 trial in microsatellite stable colorectal cancer (MSS CRC). The updated Phase 1 monotherapy data for XTX101 at the recommended Phase 2 dose (RP2D) continues to demonstrate minimal treatment-related adverse events, consistent with tumor-activated molecule design, and a 33% disease control rate across a range of late-line and IO refractory advanced solid tumors. The company also reported a confirmed partial response with XTX101 monotherapy in a patient with advanced PD-L1 negative NSCLC continued through 36 weeks, including complete resolution of liver metastases.
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Xilio Therapeutics, Inc. (Nasdaq: XLO) announced pipeline progress and business updates, including the initial clinical validation of tumor-selective activation technology for XTX101 and XTX202. The company reported a 50% disease control rate at higher doses for XTX202 and plans to evaluate XTX202 as monotherapy. Xilio also anticipates reporting preliminary Phase 1 safety data for XTX301 in the fourth quarter of 2023.
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Xilio Therapeutics, a clinical-stage biotechnology company, announced initial safety and efficacy data from its Phase 1/2 clinical trial evaluating XTX202, an investigational tumor-activated, engineered, beta-gamma IL-2, in patients with advanced solid tumors. The trial showed a disease control rate of 50% at higher doses (≥2.8 mg/kg) and 31% across all dose levels. Treatment-related adverse events were primarily Grade 1-2, with no signs of vascular leak syndrome reported. Two patients continued treatment for more than 1 year. Xilio plans to evaluate XTX202 as a monotherapy in a Phase 2 trial for advanced melanoma and renal cell carcinoma.
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Xilio Therapeutics, Inc.

Nasdaq:XLO

XLO Rankings

XLO Stock Data

41.34M
16.43M
31.9%
49.33%
0.16%
Research and Development in Biotechnology
Professional, Scientific, and Technical Services
Link
United States of America
WALTHAM

About XLO

xilio is a waltham, massachusetts-based biopharmaceutical company focused on defeating cancer. the company’s proprietary technology enables the explosion of therapeutic activity specifically within the tumor while reducing toxicity throughout the body – a nod to the company name, xilio, derived from the latin term, ex nihilo, meaning creation or big-bang. xilio is applying its technology to build a broad pipeline of engineered antibodies, cytokines and chemokines as potential new options for people living with cancer. to learn more, please visit www.xiliotx.com.