Xencor Stock Price, News & Analysis

Caris Life Sciences and Xencor, Inc. have expanded their collaboration to research and develop novel XmAb bispecific antibodies aimed at treating cancer. This agreement builds on the initial partnership from August 2022 and will increase the number of targets and cancer types that Caris will investigate using its Caris Discovery platform. Xencor gains exclusive global rights to develop products from up to three discovered targets. Caris will receive an upfront payment and could earn up to $187 million in milestone payments, along with royalties on future sales.

Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company, will have its CEO Bassil Dahiyat present at the 41st Annual J.P. Morgan Healthcare Conference. The presentation is scheduled for January 11, 2023, at 3:45 p.m. PST. A live webcast will be accessible in the Investors section of Xencor's website, with a replay available for 30 days post-event. Xencor focuses on developing engineered antibodies and cytokines to treat cancer and autoimmune diseases, with over 20 clinical candidates and three marketed medicines through partnerships.

Xencor, Inc. (NASDAQ: XNCR) announced new clinical data from its Phase 1 study of plamotamab, a CD20 x CD3 bispecific antibody for relapsed or refractory non-Hodgkin lymphomas, presented at the ASH Annual Meeting. The data indicated a well-tolerated safety profile, with a 52% overall response rate in patients with DLBCL or HGBCL, and 88% in follicular lymphoma. Adverse events included neutropenia and cytokine release syndrome. Xencor aims to develop plamotamab in various chemotherapy-free regimens, indicating a strategic focus on improving treatment outcomes for B-cell cancers.

Xencor, a clinical-stage biopharmaceutical company listed on NASDAQ under the symbol XNCR, announced participation in two upcoming investor conferences. The first is the Jefferies London Healthcare Conference on November 15, 2022, at 8:00 a.m. GMT, followed by the Piper Sandler 34th Annual Healthcare Conference on November 29, 2022, at 12:30 p.m. EST. Live webcasts will be accessible via the company’s website, with replays available for 30 days post-event. Xencor specializes in engineered antibodies and cytokines for cancer and autoimmune disease treatments.

Xencor, Inc. (NASDAQ:XNCR) presented initial data from the Phase 2 study of vudalimab, a bispecific antibody, targeting metastatic castration-resistant prostate cancer (mCRPC) at the Society for Immunotherapy of Cancer Annual Meeting in Boston. The study included nine patients, with three showing more than 50% PSA reductions. However, safety concerns led to a reduction in chemotherapy intensity for future cohorts. Xencor plans to explore alternative chemotherapy combinations and has multiple ongoing studies for vudalimab and other XmAb programs.

Xencor, Inc. (NASDAQ:XNCR) reported Q3 2022 results, showing $27.3 million in revenue, up from $19.7 million in Q3 2021. The net loss decreased to $32.8 million or $(0.55) per share, compared to $(0.69) in Q3 2021. Key highlights include promising results from the XmAb564 IL-2 cytokine study, demonstrating a 117-fold Treg expansion. Xencor anticipates ending 2022 with $575 million to $600 million in cash and expects to fund R&D through 2025. Additional updates on clinical programs are forthcoming.

Xencor announced positive topline results from the Phase 1a study of XmAb564, a novel therapy targeting regulatory T cells (Tregs) for autoimmune diseases. A 117-fold increase in CD25^bright Tregs was observed at the highest dose, with sustained activity over three weeks. XmAb564 was well-tolerated, showing no serious adverse events, and the first patient has been dosed in a Phase 1b study for atopic dermatitis and psoriasis. Results will be discussed in a webcast today at 4:30 PM ET.

Xencor, Inc. (NASDAQ: XNCR) announced it will present clinical data from its Phase 1 study of plamotamab, a CD20 x CD3 bispecific antibody, at the ASH Annual Meeting on December 12, 2022. Plamotamab showed encouraging results in patients with relapsed non-Hodgkin’s lymphoma. The study indicated a 47.4% overall response rate (ORR) in patients with diffuse large B-cell lymphoma and a 100% ORR in those with follicular lymphoma. Despite common adverse events like cytokine release syndrome, the treatment was generally well tolerated. This marks a significant step in Xencor's development of targeted cancer therapies.

Xencor, Inc. (NASDAQ: XNCR) announced it will release its third quarter 2022 financial results on November 7, 2022, after market close. A conference call and webcast will follow at 4:30 p.m. ET to discuss the results and provide an update on corporate activities. Xencor is engaged in developing engineered antibodies and cytokines to treat cancer and autoimmune diseases, with over 20 candidates in clinical trials and three marketed medicines utilizing its XmAb® technology.