Welcome to our dedicated page for Xortx Therapeutics news (Ticker: XRTX), a resource for investors and traders seeking the latest updates and insights on Xortx Therapeutics stock.
XORTX Therapeutics Inc. (XRTX) news covers a late-stage clinical pharmaceutical company focused on developing therapies for gout, progressive kidney disease, and related disorders driven by aberrant purine metabolism and elevated uric acid. Company updates emphasize programs that target xanthine oxidase, a key enzyme in uric acid production, and explore how genetic and molecular insights can inform treatment strategies.
Readers of this page can follow announcements on XORTX’s lead XRx-026 gout program and its proprietary oxypurinol formulation XORLO™, including regulatory interactions, Investigational New Drug (IND) preparation, clinical trial plans, and progress toward potential New Drug Application (NDA) submissions. News also highlights development of XRx-008 for autosomal dominant polycystic kidney disease (ADPKD), XRx-101 for acute kidney and organ injury associated with respiratory virus infections, and XRx-225 for Type 2 diabetic nephropathy.
In addition to clinical and scientific milestones, XRTX news items report on financing activities such as registered direct offerings, at-the-market issuances, and private placements, as well as Nasdaq listing updates, including minimum bid price deficiency notices and compliance timelines. Corporate developments, including board changes, strategic planning, and the planned acquisition of the VB4-P5 renal anti-fibrotic program from Vectus Biosystems Limited, are also covered.
This news feed brings together scientific findings on xanthine oxidase and uric acid, regulatory and clinical progress in gout and kidney disease programs, and capital markets disclosures. Investors and observers can use it to monitor how XORTX’s research, pipeline evolution, and financing decisions shape the company’s efforts in gout and kidney-related therapeutics.
XORTX Therapeutics Inc. announced it has received a notification from Nasdaq regarding non-compliance with the minimum bid price rule, as its shares traded below $1.00 for 30 consecutive business days. Despite this, the company's listing on Nasdaq remains unaffected at this time. XORTX has 180 days to regain compliance. The firm is focused on developing therapies for progressive kidney diseases and has advanced clinical programs including XRx-008 for ADPKD and XRx-101 for acute kidney injury related to COVID-19.
XORTX Therapeutics has appointed Dr. Stacy Evans as Chief Business Officer to spearhead the search for a global partner for the Phase 3 development of its XRx-008 program, targeting autosomal dominant polycystic kidney disease (ADPKD). With nearly 25 years of experience, including 12 years at Pfizer, Dr. Evans will enhance the company's business development outreach. Additionally, Russo Partners will manage public relations for XORTX, further strengthening its market position. XRX-008 is poised for clinical trials in 2023, with recent patent grants aiding the program's progression.
XORTX Therapeutics announced the presentation of a peer-reviewed abstract at ASN Kidney Week 2022, highlighting findings from studies on XRx-008, a xanthine oxidase inhibitor. The research in rodent models of polycystic kidney disease (PKD) shows that increased uric acid levels worsen kidney function and structure, while XRx-008 significantly blocks these harmful effects. The data support the company’s application for Orphan Drug Designation for XRx-008, indicating potential for further development in treating PKD.
XORTX Therapeutics Inc. (NASDAQ: XRTX) announced that its President and CEO, Dr. Allen Davidoff, will speak at several upcoming investor conferences. These include the Sidoti & Company LLC Micro-Cap Virtual Conference on November 9-10, the A.G.P. Virtual Biotech Conference on November 30-December 1, and Singular Research's Best of the Uncovereds Conference on December 8 in San Francisco. XORTX is focused on developing innovative therapies for progressive kidney disease, including drugs like XRx-008 for ADPKD and XRx-101 for COVID-19 related organ injury.
XORTX Therapeutics announced receiving a new no objection letter from Health Canada regarding its XRX-OXY-101 clinical study for treating Autosomal Dominant Polycystic Kidney Disease (ADPKD). The study has been amended to include new objectives, including assessing food effects on the drug's bioavailability and characterizing different doses. CEO Dr. Allen Davidoff highlighted increased bioavailability of XRx-008. The findings will support the upcoming phase 3 trial and regulatory submissions to the FDA and EMA.
XORTX Therapeutics Inc. (NASDAQ: XRTX) announced the online availability of a peer-reviewed abstract for the ASN Kidney Week 2022 conference. The study, highlighting the effects of elevated uric acid on polycystic kidney disease (PKD) in rodent models, indicates that increased uric acid leads to significant kidney damage, evidenced by increased kidney weight, creatinine levels, and cyst index. The findings support the company's XRx-008 program aimed at treating ADPKD and could enhance its patent portfolio. The presentation will be by Dr. Charles Edelstein and Dr. Allen Davidoff on November 4, 2022.
XORTX Therapeutics has completed a public offering, raising US$5 million through the sale of 1.4 million Common Share Units at US$1.00 each and 3.6 million Pre-Funded Units at US$0.9999 each. This offering includes common shares and warrants, allowing immediate separability upon issuance. Additionally, the company reduced the exercise price of prior warrants from US$4.77 to US$1.17. The registration statement was declared effective on September 22, 2022.
XORTX Therapeutics Inc. (NASDAQ: XRTX) has announced a public offering of 1.4 million common share units priced at $1.00 each, alongside 3.6 million pre-funded warrant units at $0.9999, aiming for gross proceeds of $5 million. The offering is set to close by October 6, 2022, pending customary conditions. Additionally, the company plans to reduce the exercise price of outstanding warrants from $4.77 to $1.17 post-offering. A.G.P./Alliance Global Partners is the sole book-running manager for this offering.
XORTX Therapeutics Inc. (NASDAQ: XRTX) announced the successful completion of its Type B Pre-phase 3 meeting with the FDA on September 16, 2022. This meeting followed the submission of a comprehensive Pre-Phase-3 Briefing Package on July 28, 2022, outlining advancements in the XRx-008 program for treating autosomal dominant polycystic kidney disease (ADPKD). The FDA's feedback focused on optimizing trial design with minimal concerns, paving the way for a single phase 3 clinical trial aimed at marketing approval. CEO Dr. Allen Davidoff emphasized the importance of FDA guidance in refining their clinical trial strategy.
XORTX Therapeutics announced the acceptance of a study abstract for presentation at the American Society of Nephrology Kidney Week 2022. The study, titled “Raising Serum Uric Acid with a Uricase Inhibitor Worsens PKD in Rat and Mouse Models”, reveals that increased serum uric acid can accelerate injury in Polycystic Kidney Disease (PKD). Dr. Charles Edelstein will present this finding, supporting XORTX’s XRx-008 program. The company anticipates further updates around the conference and aims to expand its patent portfolio based on these findings.