What Changed
Price Move History
- Daily moves over 5%
- 52 252 sessions, September 23, 2025 to September 23, 2026
- Largest daily move
- +24.7% close of August 13, 2026
- 1-year change
- -60.1% closing prices, September 23, 2025 to September 23, 2026
- 5-year change
- -90.4% closing prices, September 23, 2021 to September 23, 2026
Company Description
OptimizeRx Corporation (Nasdaq: OPRX) is a healthcare technology company that focuses on helping life science brands connect with patients and healthcare professionals (HCPs). According to company disclosures, its platform is built to support life sciences companies in reaching and engaging HCPs and patients through data-driven, privacy-safe tools that align healthcare marketing with real-world clinical needs.
OptimizeRx operates in the healthcare market in the United States and is headquartered in Waltham, Massachusetts. The company is described as working with pharmaceutical and life sciences organizations to improve how therapies are presented and supported across both healthcare professional and direct-to-consumer (DTC) channels. Its solutions are designed to support patient access to medications and to coordinate messaging across multiple points in the care journey.
Business focus and platform capabilities
The company states that its platform combines AI-driven tools such as the Dynamic Audience Activation Platform (DAAP) and proprietary Micro-Neighborhood® audiences or Micro-Neighborhood Targeting (MNT). These tools are used to deliver timely, relevant, and hyper-local engagement that aligns with brand eligibility signals and real-world healthcare data. By using deterministic audience cohorts and privacy-safe data, OptimizeRx aims to help life science brands identify clinically relevant patient and provider audiences and coordinate outreach across channels.
Earlier descriptions of OptimizeRx also highlight digital health messaging delivered via electronic health records (EHRs) and electronic prescribing (eRx) platforms. Through these in-workflow point-of-care (POC) channels, the company has offered capabilities such as financial messaging, brand and clinical messaging, brand support, and patient engagement. These offerings are intended to support patient adherence to medications by providing access to financial assistance, prior authorization support, education, and clinical information within clinical workflows.
Engagement across HCP and DTC channels
Company materials emphasize that OptimizeRx seeks to bridge the gap between HCP-focused and DTC strategies. Its tools are described as enabling synchronized marketing solutions that connect point-of-care messaging, omnichannel media, and hyper-local targeting. This includes the use of Micro-Neighborhood® audiences that are built from privacy-safe clinical and consumer data to form deterministic cohorts aligned to brand eligibility signals. These cohorts can be activated across major media channels, including digital and out-of-home (OOH) advertising through partnerships.
For example, OptimizeRx has described collaborations where its Micro-Neighborhood® Targeting data is integrated with external media networks to support clinically relevant campaigns at granular geographic levels, such as ZIP+4 or ZIP+9. In these cases, the company’s data is used to align disease prevalence and brand eligibility signals with media inventory, enabling pharmaceutical and healthcare brands to reach audiences that are more likely to be clinically relevant for specific therapies.
Point-of-care network and partnerships
OptimizeRx reports that it maintains an in-workflow point-of-care network built through partnerships with electronic health record vendors, e-prescribing platforms, health systems access partners, and other technology companies. The company has announced multi-year agreements and renewals with EHR and eRx partners, including exclusive arrangements for certain platforms. These relationships expand its reach to healthcare providers directly in the clinical workflow, including at the point of discharge and when treatment plans and patient instructions are finalized.
Through these partnerships, OptimizeRx indicates that it can increase its National Provider Identifier (NPI) reach and provide life sciences brands with access to premium inventory within clinical systems. The company has highlighted that these agreements improve visibility into future channel revenue and support its positioning in the point-of-care marketing landscape by enabling brands to engage relevant providers during key decision points in patient care.
Data, privacy, and measurement
OptimizeRx emphasizes a commitment to privacy-safe and patient-centric technology. Its Micro-Neighborhood® audiences are described as privacy-compliant, hyper-local consumer audiences created using real-world, privacy-safe clinical and consumer data. The company presents this approach as enabling deterministic cohorts without relying on broad or purely lookalike models. These cohorts are designed to be portable across major media channels and onboarders, allowing life science marketers to activate, manage, and report on omnichannel DTC advertising while maintaining privacy safeguards.
The company also highlights collaborations that connect its audience data with external identity graphs. In these integrations, OptimizeRx’s patented, deterministic Micro-Neighborhood® audience data is mapped to third-party identity infrastructure to support onboarding, curation, and measurement. Reported benefits include more accurate measurement of exposed audiences, reduced audience loss during onboarding, higher projected audience quality, and a reduced gap between projected and actual audience composition for media planning.
Customer base and market orientation
Across its public communications, OptimizeRx describes its primary customers as life science and pharmaceutical manufacturers and healthcare marketing agencies. It reports that it partners with some of the world’s leading pharmaceutical and life sciences companies. The platform is positioned to support these clients in reaching both HCP and DTC audiences, using patient identification technologies and omnichannel networks to help drive faster treatment decisions and improved patient outcomes.
Company materials also reference key performance indicators related to revenue from top pharmaceutical manufacturers, net revenue retention, and revenue per full-time employee. These metrics are used by the company to describe its performance and relationships with large pharmaceutical clients, though specific figures are time-bound and reported in periodic financial releases rather than as permanent characteristics.
Corporate structure and listing
OptimizeRx Corporation is incorporated in Nevada and files periodic reports and current reports with the U.S. Securities and Exchange Commission under Commission File Number 001-38543. The company’s common stock trades on Nasdaq under the ticker symbol OPRX. SEC filings and company press releases identify its headquarters as being located in Waltham, Massachusetts.
Role within healthcare technology and marketing
Within the broader healthcare technology and life sciences marketing space, OptimizeRx positions itself around three main themes drawn from its disclosures: point-of-care engagement, omnichannel audience activation, and privacy-safe, data-driven targeting. Its point-of-care capabilities are built on integrations with EHR and eRx systems and health system partners. Its omnichannel activation is supported by DAAP and Micro-Neighborhood® or MNT audience tools that are designed to work across digital and offline media. Its privacy orientation is reflected in repeated references to privacy-safe, patient-centric technology and the use of real-world clinical data in a compliant manner.
For investors and observers, these elements frame OptimizeRx as a company focused on connecting life sciences brands with clinically relevant audiences at multiple touchpoints, from in-workflow provider interactions to consumer-facing media. The company’s own descriptions highlight its emphasis on measurable engagement, audience quality, and alignment with real-world healthcare data as key aspects of its value proposition.
Stock Performance
OptimizeRx Corporation (OPRX) closed at $7.60 on September 23, 2026. Over the past 12 months, the price has lost 60.1%.
OPRX Metrics & Rankings
Price returns through September 23, 2026. Month-to-date and YTD include the first trading day. Ranking links may use different dates.
Latest News
OptimizeRx Corporation has 10 recent news articles, with the latest published yesterday. Of the recent coverage, 8 articles coincided with positive price movement and 2 with negative movement. Key topics include AI, earnings, conferences. View all OPRX news →
SEC Filings
OptimizeRx Corporation has filed 10 recent SEC filings, including 10 Form 4. The most recent filing was submitted on September 2, 2026. SEC filings provide transparency into a company's financial condition, material events, and regulatory compliance. View all OPRX SEC filings →
Financial Highlights
OptimizeRx Corporation generated $109.4M in revenue in FY2025, retaining a 67.3% gross margin, operating income reached $11.7M (10.7% operating margin), and net income was $5.1M, reflecting a 4.7% net profit margin. Diluted earnings per share stood at $0.27. The company generated $18.7M in operating cash flow. With a current ratio of 3.04, the balance sheet reflects a strong liquidity position.
Upcoming Events
OpenPath integration
CFO appointment
Strategic advisor term
OptimizeRx Corporation has 3 upcoming scheduled events. The next event, "OpenPath integration", is scheduled for October 1, 2026 (in 7 days). Investors can track these dates to stay informed about potential catalysts that may affect the OPRX stock price.
Short Interest History
Short interest in OptimizeRx Corporation (OPRX) currently stands at 1.2 million shares, up 0.8% from the previous reporting period, representing 7.3% of the float. Since September 2025, short interest has decreased by 32.3%. The 6.3 days to cover indicates moderate liquidity for short covering.
Days to Cover History
Days to cover for OptimizeRx Corporation (OPRX) currently stands at 6.3 days, up 67.1% from the previous period. This moderate days-to-cover ratio suggests reasonable liquidity for short covering, requiring about a week of average trading volume. The days to cover has increased 32.4% over the past year, indicating either rising short interest or declining trading volume. The ratio has shown significant volatility over the period, ranging from 1.8 to 8.0 days.
OPRX Company Profile & Sector Positioning
OptimizeRx Corporation (OPRX) operates in the Health Information Services industry within the broader Healthcare sector and is listed on the NASDAQ.
Investors comparing OPRX often look at related companies in the same sector, including Spok Holdings, Inc (SPOK), TruBridge, Inc. (TBRG), NRC Health (NRC), Definitive Healthcare Corp. (DH), and So-Young International Inc. (SY). Comparing financial metrics, valuation ratios, and stock performance across these peers can help investors evaluate OPRX's relative position within its industry.