Talphera (TLPH) Stock Price, News & Analysis
What Changed
Price Move History
- Daily moves over 5%
- 54 252 sessions, October 22, 2025 to October 22, 2026
- Largest daily move
- +20.9% close of February 23, 2026
- 1-year change
- -11% closing prices, October 22, 2025 to October 22, 2026
- 1-month change
- -10.3% closing prices, September 22, 2026 to October 22, 2026
Company Description
Talphera, Inc. develops and seeks to commercialize specialty pharmaceutical therapies for use in medically supervised settings. The company’s disclosed business centers on product candidates used in controlled clinical or hospital environments, with its lead program focused on anticoagulation for extracorporeal blood circuits used during renal replacement therapy.
The company’s lead product candidate, Niyad, is a lyophilized formulation of nafamostat. Talphera describes Niyad as an investigational anticoagulant for the extracorporeal circuit, and company materials state that it is being studied under an investigational device exemption. Niyad has received Breakthrough Device Designation from the U.S. Food and Drug Administration. The clinical program is tied to continuous renal replacement therapy, a critical-care setting involving extracorporeal blood filtration.
Talphera’s portfolio is described as including nafamostat product candidates and pre-filled syringe product candidates. Nafamostat candidates identified for the company include Niyad and LTX-608. The company’s operating model is based on advancing specialized therapeutic candidates through development, regulatory and clinical processes, and potential commercialization in medically supervised care settings.
Talphera is incorporated in Delaware and is headquartered in San Mateo, California. Its common stock trades on The Nasdaq Capital Market under the symbol TLPH. Public disclosures also show financings involving common stock and pre-funded warrants, equity incentive plans, stockholder voting matters, board governance and Nasdaq listing-compliance notices.
The company’s reporting history reflects a narrowed business focus following the divestment of DSUVIA, which Talphera has treated as a discontinued operation in its financial reporting. The current public-company profile is therefore centered on specialty pharmaceutical development, the Niyad program, clinical and regulatory activities related to medically supervised use, and the capital and governance matters associated with a small public life-sciences issuer.
Stock Performance
Talphera (TLPH) closed at $1.05 on October 22, 2026. Over the past 12 months, the price has lost 11.0%.
TLPH Metrics & Rankings
Price returns through October 22, 2026. Month-to-date and YTD include the first trading day. Ranking links may use different dates.
Latest News
Talphera has 10 recent news articles. Of the recent coverage, 5 articles coincided with positive price movement and 4 with negative movement. Key topics include earnings, earnings date. View all TLPH news →
SEC Filings
Talphera has filed 10 recent SEC filings, including 7 Form 4, 1 Form 10-Q, 1 Form 8-K, 1 Form SCHEDULE 13G/A. The most recent filing was submitted on August 12, 2026. SEC filings provide transparency into a company's financial condition, material events, and regulatory compliance. View all TLPH SEC filings →
Financial Highlights
Talphera generated $28K in revenue in FY2025, operating income reached -$13.5M, and net income was -$14.3M. The company generated -$11.4M in operating cash flow. The current ratio was 5.49, measuring current assets divided by current liabilities.
Upcoming Events
Short Interest History
Short interest in Talphera (TLPH) currently stands at 721.5 thousand shares, up 3.0% from the previous reporting period, representing 1.9% of the float. Since October 2025, short interest has decreased by 59.7%.
Days to Cover History
Days to cover for Talphera (TLPH) currently stands at 6.3 days. The ratio is the reported short interest divided by the average daily trading volume. Across the settlements charted above, it has ranged from 1.3 to 8.7 days.
TLPH Company Profile & Sector Positioning
Talphera (TLPH) operates in the Drug Manufacturers - Specialty & Generic industry within the broader Healthcare sector and is listed on the NASDAQ.
Investors comparing TLPH often look at related companies in the same sector, including AYTU BioPharma, Inc. (AYTU), Gelteq Limited (GELS), Flora Growth Corp. (FLGC), TherapeuticsMD, Inc. (TXMD), and Incannex Healthcare Limited (IXHL). Comparing financial metrics, valuation ratios, and stock performance across these peers can help investors evaluate TLPH's relative position within its industry.