Opaleye adds Alpha Cognition (ACOG) shares in open-market purchases

Rhea-AI Filing Summary

Alpha Cognition Inc. large shareholder Opaleye Management Inc., through its fund Opaleye, L.P., reported open-market purchases of 4,079 shares of Common Stock. The buys occurred on March 6 and March 9, 2026 at weighted average prices of $5.7989 and $5.8477 per share, across trade ranges disclosed in footnotes.

Following these transactions, Opaleye, L.P. held 2,420,946 shares indirectly, and a separately managed account overseen by Opaleye held 90,000 shares. Opaleye Management Inc. states it may be deemed a beneficial owner but disclaims beneficial ownership beyond its pecuniary interest.

Insider Trade Summary

Net Buyer: 4,079 shares ($23,760)

Net Buy 3 txns

Insider Opaleye Management Inc.

Role 10% Owner

Bought 4,079 shs ($24K)

Type	Security	Shares	Price	Value
Purchase	Common Stock, no par value	2,179	$5.8477	$13K
Purchase	Common Stock, no par value	1,900	$5.7989	$11K
holding	Common Stock, no par value	--	--	--

Holdings After Transaction: Common Stock, no par value — 2,420,946 shares (Indirect, By Opaleye, L.P.)

Footnotes (1)

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.70 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.785 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Opaleye Management Inc.

(Last) (First) (Middle)

ONE BOSTON PLACE, 26TH FLOOR

(Street)

BOSTON MA 02108

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Alpha Cognition Inc. [ ACOG ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
03/06/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock, no par value	03/06/2026		P		1,900	A	$5.7989(3)	2,418,767	I	By Opaleye, L.P.(1)(5)
Common Stock, no par value	03/09/2026		P		2,179	A	$5.8477(4)	2,420,946	I	By Opaleye, L.P.(1)(5)
Common Stock, no par value								90,000	I	By Managed Account(2)(5)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

3. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.70 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

4. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.785 to $5.85. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

5. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

	Opaleye Management Inc., By: /s/ James Silverman, President	03/10/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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FAQ

What insider activity did Opaleye Management report for Alpha Cognition (ACOG)?

Opaleye Management reported open-market purchases of 4,079 Alpha Cognition common shares. The trades were executed on March 6 and March 9, 2026 at weighted average prices around $5.80 per share, adding modestly to an already large indirect position.

At what prices did Opaleye buy Alpha Cognition (ACOG) shares?

Opaleye’s reported weighted average prices were $5.7989 and $5.8477 per share. Footnotes state the March 9 trades ranged from $5.70 to $5.85 and March 6 trades from $5.785 to $5.85, with full breakdowns available on request from the reporting person.

How many Alpha Cognition (ACOG) shares does Opaleye hold after these transactions?

After the reported trades, Opaleye, L.P. held 2,420,946 Alpha Cognition common shares indirectly. A separately managed account overseen by Opaleye held an additional 90,000 shares, reflecting sizable overall exposure managed through different investment vehicles.

Is Opaleye Management a major Alpha Cognition (ACOG) shareholder?

Opaleye Management is identified as a ten percent owner of Alpha Cognition. The Form 4 shows large indirect holdings via Opaleye, L.P. and a managed account, though Opaleye disclaims beneficial ownership beyond its pecuniary interest in the reported securities.

How does Opaleye describe its beneficial ownership of Alpha Cognition (ACOG)?

Opaleye states it may be deemed to beneficially own shares held by its fund and a managed account. However, it expressly disclaims beneficial ownership of the reported Alpha Cognition shares except to the extent of its pecuniary interest, limiting how the filings should be interpreted.

Were the Alpha Cognition (ACOG) insider purchases single trades or price ranges?

The reported prices are weighted averages, not single trade prices. Footnotes explain the March 9 purchases spanned $5.70–$5.85 and March 6 purchases $5.785–$5.85, with Opaleye offering to provide detailed trade-by-trade price data upon request.