Alpha Cognition (ACOG) holder Opaleye adds 1,331 common shares

Rhea-AI Filing Summary

Alpha Cognition Inc. major holder Opaleye Management Inc., through Opaleye, L.P., made an open-market purchase of 1,331 shares of common stock at a weighted average price of $5.782 per share, with individual trade prices ranging from $5.76 to $5.79. Following this purchase, Opaleye, L.P. indirectly holds 2,435,343 shares, and a separately managed account overseen by Opaleye holds 90,000 shares.

Insider Trade Summary

Net Buyer: 1,331 shares ($7,696)

Net Buy 2 txns

Insider Opaleye Management Inc.

Role 10% Owner

Bought 1,331 shs ($8K)

Type	Security	Shares	Price	Value
Purchase	Common Stock, no par value	1,331	$5.782	$8K
holding	Common Stock, no par value	--	--	--

Holdings After Transaction: Common Stock, no par value — 2,435,343 shares (Indirect, By Opaleye, L.P.)

Footnotes (1)

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.76 to $5.79. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Opaleye Management Inc.

(Last) (First) (Middle)

ONE BOSTON PLACE, 26TH FLOOR

(Street)

BOSTON MASSACHUSETTS 02108

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Alpha Cognition Inc. [ ACOG ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
03/16/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock, no par value	03/16/2026		P		1,331	A	$5.782(3)	2,435,343	I	By Opaleye, L.P.(1)(4)
Common Stock, no par value								90,000	I	By Managed Account(2)(4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

3. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.76 to $5.79. The reporting person undertakes to provide, upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

4. Opaleye Management Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.

	Opaleye Management Inc., By: /s/ James Silverman, President	03/18/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transaction did Opaleye Management report for Alpha Cognition (ACOG)?

Opaleye Management, through Opaleye, L.P., reported buying 1,331 Alpha Cognition common shares in the open market. The weighted average purchase price was $5.782 per share, with trades executed between $5.76 and $5.79 during the transaction day.

How many Alpha Cognition (ACOG) shares does Opaleye now indirectly hold?

After the reported transaction, Opaleye, L.P. indirectly holds 2,435,343 Alpha Cognition common shares. In addition, a separately managed account overseen by Opaleye holds 90,000 shares, reflecting Opaleye Management’s overall indirect exposure to the company’s common stock.

Was the Alpha Cognition (ACOG) insider trade by Opaleye a market purchase or another type of transaction?

The Alpha Cognition transaction by Opaleye, L.P. was an open-market purchase of common stock. It is classified with transaction code “P,” indicating a standard buy in the open market or a private transaction at negotiated prices.

At what price range did Opaleye buy Alpha Cognition (ACOG) shares?

The reported weighted average purchase price was $5.782 per share for Alpha Cognition. Individual trades occurred at prices ranging from $5.76 to $5.79, reflecting several executions aggregated into the single reported transaction.

How is Opaleye Management’s ownership in Alpha Cognition (ACOG) structured?

Opaleye Management is the investment manager of Opaleye, L.P. and portfolio manager of a separately managed account. Shares are held directly by these entities, and Opaleye may be deemed to beneficially own them through its roles in managing the fund and the account.

Does Opaleye Management fully acknowledge beneficial ownership of its Alpha Cognition (ACOG) shares?

Opaleye Management disclaims beneficial ownership of the reported Alpha Cognition shares except to the extent of its pecuniary interest. This means it does not concede full beneficial ownership for regulatory purposes beyond its economic stake in the securities.